Sperm DNA damage may play role in unexplained miscarriages

NCT ID NCT02572154

Completed Knowledge-focused Sponsor: University Hospital, Toulouse Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study looked at whether sperm DNA damage is linked to early recurrent pregnancy loss in couples where standard tests found no cause. Researchers compared sperm samples from men in couples with unexplained recurrent pregnancy loss to those from men who had a healthy pregnancy. The goal was to see if higher sperm DNA fragmentation is more common in the miscarriage group.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

What this could lead to: If this study finds a link, it could point toward new ways to evaluate male fertility in couples with recurrent pregnancy loss.
What could go wrong: This is a small, completed observational study, not a treatment trial. It may not prove cause and effect, and results may not apply to all couples.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Get updates

Get notified about this study

Sign up to get updates when this study changes or when new studies for RECURRENT PREGNANCY LOSS are added.

Our safety recommendation!

By submitting, you agree to our Terms of use

Conditions

The condition(s) this trial relates to.

habitual spontaneous abortion pregnancy loss, recurrent, 4 pregnancy loss, recurrent, susceptibility

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

RECURRENT PREGNANCY LOSS

Contacts and locations

Locations

APHM

Marseille, France
Chu Bordeaux

Bordeaux, France
Chu Toulouse

Toulouse, France

More trials for these conditions

Other studies related to the condition(s) this trial covers.