New hope for myeloma patients: drug combo aims to prevent relapse after transplant

NCT ID NCT05243797

Recruiting now Disease control Sponsor: European Myeloma Network B.V. Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests whether adding the drug teclistamab to standard maintenance therapy (lenalidomide) can help keep multiple myeloma from coming back after a stem cell transplant. About 1,600 adults with newly diagnosed myeloma who have already responded to initial treatment will be randomly assigned to receive lenalidomide alone, teclistamab alone, or both drugs together. The goal is to see which approach offers the longest time without the cancer progressing.

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Conditions

The condition(s) this trial relates to.

plasma cell myeloma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

MULTIPLE MYELOMA

Contacts and locations

Locations

"Centre intégré universitaire de santé et de services sociaux de l'Estrie - Centre Hospitalier Universitaire de Sherbrooke (CIUSSS de l'Estrie - CHUS)"
RECRUITING

Sherbrooke, Canada
A Real e Benemérita Associação Portuguesa de Beneficência
RECRUITING

São Paulo, Brazil
A.O.Spedali Civili di Brescia
RECRUITING

Brescia, Italy
A.O.U. Città della Salute e della Scienza di Torino - SC Ematologia U
RECRUITING

Torino, 10126, Italy
A.O.U. Ospedali Riuniti di Trieste
RECRUITING

Trieste, Italy
A.O.U. di Bologna - Policlinico S. Orsola Malpighi
RECRUITING

Bologna, Italy
AOU G. Baccelli
RECRUITING

Bari, Italy
AOU Policlinico di Bari
RECRUITING

Bari, Italy
ASST Papa Giovanni XXIII Hospital
RECRUITING

Bergamo, Italy
Aarhus Universitetshospital
RECRUITING

Aarhus, Denmark
Abramson Cancer Center University of Pennsylvania Medical Center
RECRUITING

Philadelphia, Pennsylvania, 19104, United States
AdventHealth/Blood & Marrow Transplant Center, Florida Hospital Medical Group
RECRUITING

Orlando, Florida, 32804, United States
Albert Schweitzer Ziekenhuis
RECRUITING

Dordrecht, Netherlands
Alfred Hospital
RECRUITING

Melbourne, Australia
Algemeen Ziekenhuis Delta
RECRUITING

Roeselare, Belgium
Amsterdam University Medical Center
RECRUITING

Amsterdam, Netherlands
Ankara Liv Hospital
RECRUITING

Ankara, Turkey (Türkiye)
Ankara University Hospital
RECRUITING

Ankara, Turkey (Türkiye)
Austin Health
RECRUITING

Melbourne, Australia
Azienda Ospedaliera Di Rilievo Nazionale Antonio Cardarelli
RECRUITING

Naples, Italy
Azienda Ospedaliera-Universitaria Di Cosenza
RECRUITING

Cosenza, Italy
Azienda Ospedaliero Universitaria Di Modena
RECRUITING

Modena, Italy
Azienda Ospedaliero Universitaria Ospedali Riuniti Umberto I G M Lancisi G Salesi
RECRUITING

Ancona, Italy
Azienda Ospedaliero-Universitaria Maggiore Della Carita
RECRUITING

Novara, Italy
Azienda Sanitaria Locale Al Di Alessandria
RECRUITING

Alessandria, Italy
Azienda USL IRCCS Di Reggio Emilia
RECRUITING

Reggio Emilia, Italy
BC Cancer
RECRUITING

Vancouver, Canada
Banner University Medical Center Tucson, University of Arizona
RECRUITING

Phoenix, Arizona, 85004, United States
Barwon Health University Hospital Geelong Andrew Love Cancer Centre
RECRUITING

Geelong, Australia
Beaumont Hospital
RECRUITING

Dublin, Ireland
Beijing Chaoyang Hospital
RECRUITING

Beijing, China
Beilinson Hospital
RECRUITING

Petah Tikva, Israel
Beth Israel Deaconess Medical Center
RECRUITING

Boston, Massachusetts, 02215, United States
CCAB Centro Clinico Academico Braga Associacao
WITHDRAWN

Braga, Portugal
Calvary Mater Hospital
RECRUITING

Newcastle, Australia
Careggi University Hospital
RECRUITING

Florence, Italy
Casa Sollievo Della Sofferenza
RECRUITING

San Giovanni Rotondo, Italy
Centre Hospitalier Universitaire De Bordeaux
RECRUITING

Bordeaux, France
Centre Hospitalier Universitaire De Montpellier
RECRUITING

Montpellier, France
Centre Hospitalier Universitaire De Nantes
RECRUITING

Nantes, France
Centre Hospitalier Universitaire De Poitiers
RECRUITING

Poitiers, France
Centre Hospitalier Universitaire De Toulouse
RECRUITING

Toulouse, France
Centre hospitalier universitaire de Liege
RECRUITING

Liège, Belgium
Chaim Sheba Medical Center
RECRUITING

Ramat Gan, Israel
Champalimaud Clinical Centre
RECRUITING

Lisbon, Portugal
Chonnam National University Hwasun Hospital
RECRUITING

Gwangju, South Korea
Christiana Care
RECRUITING

Newark, Delaware, 19718, United States
Clinic Ottakring
RECRUITING

Vienna, Austria
Clinical Centre of Kragujevac
RECRUITING

Kragujevac, Serbia
Clinical Centre of Nis
RECRUITING

Niš, Serbia
Clinical Centre of Vojvodina
RECRUITING

Novi Sad, Serbia
Clínica Medica São Germano,Grupo Oncoclínicas Pesquisa Clínica
RECRUITING

São Paulo, Brazil
Colorado Blood Cancer Institute
RECRUITING

Denver, Colorado, 80218, United States
Concord Repatriation General Hospital
RECRUITING

Sydney, Australia
Cork University Hospital
RECRUITING

Cork, Ireland
Cross Cancer Institute
RECRUITING

Edmonton, Canada
Dartmouth-Hitchcock Medical Center
WITHDRAWN

Lebanon, New Hampshire, 03756, United States
Departamento de Oncologia Clínica AC Camargo Cancer Center
RECRUITING

São Paulo, Brazil
Department of Hematology and Bone Marrow Transplant Centre, Azienda Ospedaliero - Universitaria di Parma
RECRUITING

Parma, Italy
Department of Hematology and Transplantology University Clinical Center
RECRUITING

Gdansk, Poland
Department of Hematology, CH Jolimont
RECRUITING

La Louvière, Belgium
Department of Hematology, CHU Lille
RECRUITING

Lille, France
Department of Oncology, Asan Medical Center
RECRUITING

Seoul, South Korea
Dijklander Ziekenhuis
RECRUITING

Hoorn, Netherlands
Duke University
RECRUITING

Durham, North Carolina, 27710, United States
East Carolina University
NOT_YET_RECRUITING

Greenville, North Carolina, 27858, United States
Ege University Medical faculty Hospital Internal Medicine Department Adult Hematology Unit
RECRUITING

Izmir, Turkey (Türkiye)
Ematologia, Azienda Policlinico Umberto I
RECRUITING

Roma, Italy
Emory University Hospital
RECRUITING

Atlanta, Georgia, 30322, United States
Erasmus University Medical Center Rotterdam
RECRUITING

Rotterdam, Netherlands
Erciyes University Hospital
RECRUITING

Kayseri, Turkey (Türkiye)
Evaggelismos Hospital
RECRUITING

Athens, Greece
Fakultni Nemocnice Hradec Kralove
RECRUITING

Hradec Králové, Czechia
Fakultni Nemocnice Ostrava
RECRUITING

Ostrava, Czechia
Fakultni Nemocnice Plzen
RECRUITING

Pilsen, Czechia
Flinders Medical Centre
RECRUITING

Adelaide, Australia
Florence Nightingale Hospital
RECRUITING

Istanbul, Turkey (Türkiye)
Fondazione IRCCS Policlinico San Matteo
RECRUITING

Pavia, Italy
Fox Chase Cancer Center
RECRUITING

Philadelphia, Pennsylvania, 19111, United States
Froedtert Memorial Lutheran Hospital
RECRUITING

Milwaukee, Wisconsin, 53226, United States
Gibbs Cancer Center
RECRUITING

Spartanburg, South Carolina, 29303, United States
Greenebaum Cancer Center UM of MD
RECRUITING

Baltimore, Maryland, 21201, United States
Grupo Oncoclínicas Pesquisa Clínica
WITHDRAWN

São Paulo, Brazil
Hadassah Medical Center
RECRUITING

Jerusalem, Israel
Hammersmith Hospital - Imperial College NHS Healthcare Trust
RECRUITING

London, United Kingdom
Hcor, Associacao Siria
RECRUITING

São Paulo, Brazil
Health Care Campus
RECRUITING

Haifa, Israel
Hemocentro UNICAMP, Universidade Estadual de Campinas
RECRUITING

São Paulo, Brazil
Henan Cancer Hospital
RECRUITING

Henan, China
Henry Ford St. John Hospital
NOT_YET_RECRUITING

Grosse Pointe Woods, Michigan, 3000169, United States
Hopital Saint Louis
RECRUITING

Paris, France
Hospital Italiano
RECRUITING

Buenos Aires, Argentina
Hospital Mãe de Deus - Centro Integrado de Oncologia
RECRUITING

Porto Alegre, Brazil
Hospital Paulistano, Centro de Pesquisa Clinica R. Martiniano de Carvalho
WITHDRAWN

São Paulo, Brazil
Hospital Privado
RECRUITING

Córdoba, Argentina
Hospital Santa Rita
RECRUITING

Porto Alegre, Brazil
Hospital das Clínicas da Universidade de São Paulo
RECRUITING

São Paulo, Brazil
Houston Methodist Hospital
RECRUITING

Houston, Texas, 77030, United States
Hôpital Saint-Antoine
RECRUITING

Paris, France
IDOR- Instituto D'or de pesquisa. Av. São Rafael
RECRUITING

Salvador, Brazil
IRCCS Ospedale Maggiore Policlinico
RECRUITING

Milan, Italy
IRCCS Ospedale Policlinico San Martino
RECRUITING

Genova, Italy
Inselspital
RECRUITING

Bern, Switzerland
Institut Paoli Calmettes
RECRUITING

Marseille, France
Institute of Hematology & Blood Disease Hospital Chinese Academy of Medical Science
RECRUITING

Tianjin, China
Instituto Americas de Ensino,Pesquisa e Inovação
RECRUITING

Rio de Janeiro, Brazil
Instituto Portugues De Oncologia De Lisboa Francisco Gentil E.P.E.
WITHDRAWN

Lisbon, Portugal
Instituto Portugues De Oncologia Do Porto Francisco Gentil E.P.E.
WITHDRAWN

Porto, Portugal
Izmir Economy University, Medical Point Hospital
NOT_YET_RECRUITING

Izmir, Turkey (Türkiye)
Jessa Ziekenhuis
RECRUITING

Hasselt, Belgium
John Hopkins
RECRUITING

Baltimore, Maryland, 21218, United States
Kantonsspital St. Gallen
RECRUITING

Sankt Gallen, Switzerland
Kepler Universitätsklinikum Med Campus III
RECRUITING

Linz, Austria
Klinikum Nuernberg
RECRUITING

Nuremberg, Germany
Klinikum rechts der Isar der TU Muenchen AöR
RECRUITING

München, Germany
LKH Hochsteiermark
RECRUITING

Vienna, Austria
Landeskrankenhaus, Feldkirch
RECRUITING

Feldkirch, Austria
Lehigh Valley Health Network
RECRUITING

Allentown, Pennsylvania, 18103, United States
Levine Cancer Institute
RECRUITING

Charlotte, North Carolina, 28204, United States
Lillebaelt Hospital
RECRUITING

Vejle, Denmark
Maasstad Ziekenhuis
RECRUITING

Rotterdam, Netherlands
Maxima Medisch Centrum
RECRUITING

Eindhoven, Netherlands
Medical University of South Carolina (MUSC)
RECRUITING

Charleston, South Carolina, 29425, United States
Medizinische Universitaet Innsbruck
RECRUITING

Innsbruck, Austria
Memorial Sisli Hospital, Dept of Hematology
RECRUITING

Istanbul, Turkey (Türkiye)
Moffitt at Memorial Healthcare System
RECRUITING

Tampa, Florida, 33612, United States
Montefiore Medical Cente
RECRUITING

The Bronx, New York, 10467, United States
Mount Sinai Medical Center - 2
RECRUITING

New York, New York, 10029, United States
Noordwest Ziekenhuisgroep
RECRUITING

Alkmaar, Netherlands
North China University of Science and Technology Affiliated Hospital.Hematology Department
RECRUITING

Tangshan, China
Odense University Hospital
RECRUITING

Odense, Denmark
Ohio Health Research Institute
RECRUITING

Columbus, Ohio, 43214, United States
Ohio State Medical Center, James Cancer Center
RECRUITING

Columbus, Ohio, 43210, United States
Onco Star
RECRUITING

São Paulo, Brazil
Ordensklinikum Linz GmbH
RECRUITING

Linz, Austria
Ospedale "Infermi" di Rimini
RECRUITING

Rimini, Italy
Ospedale Civile Spirito Santo di Pescara
RECRUITING

Pescara, Italy
Ospedale Oncologico 'A. Businco'
RECRUITING

Cagliari, Italy
Ospedale S. Maria della Misericordia di Udine
RECRUITING

Udine, Italy
Ospedale Santa Maria delle Croci
RECRUITING

Ravenna, Italy
Peking University First Hospital
RECRUITING

Beijing, China
Penn Medicine Lancaster General
NOT_YET_RECRUITING

Lancaster, Pennsylvania, 17602, United States
Princess Margaret Cancer Centre
RECRUITING

Toronto, Canada
QEII Health Sciences Centre
RECRUITING

Halifax, Canada
Regional General Hospital Alexandra
RECRUITING

Athens, Greece
Rigshospitalet
RECRUITING

Copenhagen, Denmark
Royal North Shore Hospital
RECRUITING

Sydney, Australia
Samsung Medical Center
RECRUITING

Seoul, South Korea
Sanatorio Britanico Rosario
RECRUITING

Rosario, Argentina
Sao Joao University Hospital Center
WITHDRAWN

Porto, Portugal
Saskatoon Cancer Center
RECRUITING

Saskatoon, Canada
Seidman Cancer Center-University Hospitals Cleveland Medical Center
RECRUITING

Cleveland, Ohio, 44106, United States
Seoul National University Hospital, Internal Medicine
RECRUITING

Seoul, South Korea
Severance Hospital
RECRUITING

Seoul, South Korea
Shandong Qilu Hospital
RECRUITING

Shandong, China
Shanghai Fourth People's Hospital
RECRUITING

Shanghai, China
Shengjing Hospital of China Medical University
RECRUITING

Shenyang, China
Sibley Memorial Hospital
RECRUITING

Washington D.C., District of Columbia, 20016, United States
Soroka University Medical Center
RECRUITING

Beersheba, Israel
St James's Hospital
RECRUITING

Dublin, Ireland
St Vincent HSHS (Green Bay Oncology)
RECRUITING

Green Bay, Wisconsin, 54301, United States
St Vincent's University Hospital
RECRUITING

Dublin, Ireland
St. Antonius Ziekenhuis
RECRUITING

Nieuwegein, Netherlands
St. Mary's Hospital
RECRUITING

Seoul, South Korea
St. Olavs hospital HF
RECRUITING

Trondheim, Norway
Sunshine Coast Health
RECRUITING

Birtinya, Australia
Tel-Aviv Sourasky Medical Center
RECRUITING

Tel Aviv, Israel
The First Affiliated Hospital of Wenzhou Medical University
RECRUITING

Wenzhou, China
The First Affiliated Hospital, Zhejiang University College of Medicine
RECRUITING

Zhejiang, China
The First Hospital of Jilin University
RECRUITING

Changchun, China
The Ottawa General Hospital
RECRUITING

Ottawa, Canada
The Royal Marsden Hospital
RECRUITING

Sutton, United Kingdom
Theageneio Cancer Hospital
RECRUITING

Thessaloniki, Greece
Tongji Hospital, Tongji Medical College of Hust
RECRUITING

Wuhan, China
Townsville University Hospital
RECRUITING

Douglas, Australia
Tufts Medical Center
RECRUITING

Boston, Massachusetts, 02111, United States
UCLA Medical Center
NOT_YET_RECRUITING

Los Angeles, California, 90095, United States
UOC Ematologia - Azienda Ospedale - Università Padova Ospedale Giustinianeo
RECRUITING

Padova, Italy
UOC Oncoematologia, Ospedale Policlinico Federico II
WITHDRAWN

Naples, Italy
UPMC Hillman Cancer Center
NOT_YET_RECRUITING

Pittsburgh, Pennsylvania, 15232, United States
Unidade Local De Saude De Gaia/Espinho E.P.E.
WITHDRAWN

Porto, Portugal
Unidade Local De Saude De Tras-Os-Montes E Alto Douro E.P.E.
RECRUITING

Vila Real, Portugal
Uniklinikum Salzburg
RECRUITING

Salzburg, Austria
Universidade Federal de São Paulo - Hospital São Paulo
RECRUITING

São Paulo, Brazil
Universitaetsklinikum Heidelberg AöR
RECRUITING

Heidelberg, Germany
Universitaetsklinikum Jena KöR
RECRUITING

Jena, Germany
Universitaetsklinikum Schleswig-Holstein AöR
ACTIVE_NOT_RECRUITING

Lübeck, Germany
Universitaetsklinikum Tuebingen AöR
RECRUITING

Tübingen, Germany
University Clinical Center of Serbia
RECRUITING

Belgrade, Serbia
University College London (UCL)
RECRUITING

London, United Kingdom
University General Hospital Of Alexandroupoli
RECRUITING

Alexandroupoli, Greece
University Hospital Basel
RECRUITING

Basel, Switzerland
University Hospital Galway
RECRUITING

Galway, Ireland
University Hospital Krems/Donau
RECRUITING

Krems, Austria
University Hospital Leuven
RECRUITING

Leuven, Belgium
University Hospital Limerick
RECRUITING

Limerick, Ireland
University Hospital Olomouc
RECRUITING

Olomouc, Czechia
University Hospital of Würzburg
RECRUITING

Würzburg, Germany
University Medical Center Groningen
RECRUITING

Groningen, Netherlands
University of California, San Diego (UCSD) Medical Center
RECRUITING

San Diego, California, 92093, United States
University of California-Davis Cancer Center
RECRUITING

Sacramento, California, 95817, United States
University of Chicago
NOT_YET_RECRUITING

Chicago, Illinois, 3000168, United States
University of Cincinnati
RECRUITING

Cincinnati, Ohio, 45221, United States
University of Colorado Hospital
RECRUITING

Aurora, Colorado, 80045, United States
University of Illinois Medical Center at Chicago
RECRUITING

Chicago, Illinois, 60612, United States
University of Wisconsin Hospital and Clinics
RECRUITING

Madison, Wisconsin, 53792, United States
Universitätsklinikum Hamburg - Eppendorf
RECRUITING

Hamburg, Germany
Uniwersytecki Szpital Kliniczny w Poznaniu
RECRUITING

Poznan, Poland
Vanderbilt-Ingram Cancer Center (VICC)
RECRUITING

Nashville, Tennessee, 37232, United States
Virginia Oncology Associates
RECRUITING

Norfolk, Virginia, 23502, United States
Vseobecna Fakultni Nemocnice V Praze
RECRUITING

Prague, Czechia
Yale New Haven Hospital
RECRUITING

New Haven, Connecticut, 06519, United States

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