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A multicenter, randomized, phase III registration trial of transplantation of NiCord®, ex vivo expanded, UCB-derived, stem and progenitor cells, vs. unmanipulated UCB for patients with hematological malignancies

NCT ID NCT02730299

Completed Sponsor: Gamida Cell ltd Source: ClinicalTrials.gov ↗

Summary

This study is an open-label, controlled, multicenter, international, Phase III, randomized study of transplantation of NiCord® versus transplantation of one or two unmanipulated, unrelated cord blood units in patients with acute lymphoblastic leukemia or acute myeloid leukemia, myelodysplastic syndrome, chronic myeloid leukemia or lymphoma, all with required disease features rendering them eligible for allogeneic transplantation.

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes NO responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

Locations

  • Boston Children's Hospital

    Boston, Massachusetts, 02115, United States

  • Careggi University Hospital

    Florence, 50134, Italy

  • Chaim Sheba Medical Center, The Edmond and Lily Safra Children's hospital

    Tel Litwinsky, Israel

  • Children's Hospital Colorado

    Denver, Colorado, 80045, United States

  • Children's Medical Center of Dallas

    Dallas, Texas, 75235, United States

  • City of Hope

    Los Angeles, California, 91010, United States

  • Cleveland Clinic Children's

    Cleveland, Ohio, 44195, United States

  • Dana-Dwek Children's Hospital, Tel-Aviv Sourasky Medical Center

    Tel Aviv, Israel

  • Dana-Farber Cancer Institute

    Boston, Massachusetts, 02215, United States

  • Duke University Medical Center

    Durham, North Carolina, 27710, United States

  • Hadassah Medical Center

    Jerusalem, Israel

  • Henry Ford Medical Center

    Detroit, Michigan, United States

  • Hospital Israelita Albert Einstein

    São Paulo, Brazil

  • Hospital Universitari Vall d'Hebron pediatrics

    Barcelona, 08035, Spain

  • Hospital Universitario La Fe

    Valencia, 46009, Spain

  • Hospital Universitario Virgen del Rocío

    Seville, Spain

  • Hospital Universitario y Politécnico La Fe (pediatric)

    Valencia, Spain

  • Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo

    São Paulo, São Paulo, 05403-010, Brazil

  • Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo Pediatrics

    São Paulo, São Paulo, 05403-010, Brazil

  • Hospital das Clínicas da Faculdade de Medicina de Ribeirão Preto da Universidade de São Paulo

    São Paulo, São Paulo, 14048-900, Brazil

  • Hospital de la Santa Creu i Sant Pau

    Barcelona, Spain

  • ICO Bellvitge

    Barcelona, 08908, Spain

  • Instituto Nacional de Câncer José Alencar Gomes da Silva - INCA

    Rio de Janeiro, Rio de Janeiro, 20230-130, Brazil

  • Instituto Português de Oncologia de Lisboa Francisco Gentil

    Lisbon, 1099-023, Portugal

  • Loyola University, Cardinal Bernardin Cancer Center

    Maywood, Illinois, 60153, United States

  • Manchester University NHS Foundation Trust

    Manchester, M13 9WL, United Kingdom

  • National University Cancer Institute

    Singapore, 119074, Singapore

  • Northwestern University

    Evanston, Illinois, 60208, United States

  • Oregon Health & Science University

    Portland, Oregon, 97239, United States

  • Ospedale Pediatrico Bambino Gesù

    Rome, 00165, Italy

  • Prinses Maxima Centrum voor Kinderoncologie B.V.

    Utrecht, 3584 CS, Netherlands

  • Queen Elizabeth Hospital

    Birmingham, B15 2GW, United Kingdom

  • Rabin Medical Center, Beilinson Hospital

    Petah Tikva, Israel

  • Rambam

    Haifa, Israel

  • Robert Debré

    Paris, 75019, France

  • Rutgers Cancer Institute of New Jersey

    New Brunswick, New Jersey, 08901, United States

  • Sant Joan de Deu

    Barcelona, 08950, Spain

  • Singapore General Hospital

    Singapore, 169608, Singapore

  • St James Hospital

    Leeds, LS9 7TF, United Kingdom

  • Stanford University Cancer Institute

    Palo Alto, California, United States

  • Tel-Aviv Sourasky Medical Center

    Tel Aviv, Israel

  • The Royal Marsden NHS Foundation Trust

    Sutton, Surrey, SM2 5PT, United Kingdom

  • The University of Maryland Medicine Center

    Baltimore, Maryland, 21201, United States

  • UC San Diego Moores Cancer Center

    San Diego, California, 92093, United States

  • UCLA

    Los Angeles, California, 90095, United States

  • UPMC Children's Hospital of Pittsburgh

    Pittsburgh, Pennsylvania, 15224, United States

  • University Hospital Vall d'Hebron

    Barcelona, 08035, Spain

  • University Medical Center Utrecht

    Utrecht, 3503 AB, Netherlands

  • University of Kansas Cancer Center

    Westwood, Kansas, 66205, United States

  • University of Minnesota Masonic Cancer Center

    Minneapolis, Minnesota, 55455, United States

  • University of Virginia Cancer Center

    Charlottesville, Virginia, 22903, United States

  • West Cancer Clinic

    Germantown, Tennessee, 38138, United States

Conditions

Explore the condition pages connected to this study.

ACUTE LEUKEMIA ACUTE LYMPHOBLASTIC LEUKEMIA (ALL) ACUTE MYELOGENOUS LEUKEMIA (AML) CHRONIC MYELOGENOUS LEUKEMIA (CML) HEMATOLOGICAL MALIGNANCIES LYMPHOMA MYELODYSPLASTIC SYNDROME (MDS)