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Can a gentle massage technique calm PMS symptoms and the nervous system?

NCT ID NCT07814807

Symptom relief Sponsor: Izmir Democracy University Source: ClinicalTrials.gov ↗

What the study statuses mean

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Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting This study
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Sep 11, 2026 · Last updated Sep 11, 2026

Summary

Researchers are testing whether manual lymphatic drainage, a gentle massage that supports lymph flow, can ease premenstrual symptoms and change autonomic nervous system activity in women with PMS. Sixty women aged 18 to 40 will be assigned to one of three groups: drainage performed by a physiotherapist, drainage they perform on themselves after training, or a sham version. Each woman receives six sessions during the two weeks before her period. The team measures symptom severity, heart rate variability, blood pressure, pain, swelling, fatigue, mood, and quality of life before, during, and after the sessions.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
manual lymphatic drainage, a gentle massage technique that supports lymph flow, taught both as a therapist-led treatment and as a self-massage routine
What this could lead to
If it works, women with PMS could gain a low-cost, drug-free way to ease bloating, pain, and mood symptoms by doing a simple massage routine at home.
What could go wrong
The trial is small, with 60 women, and massage studies often show strong placebo effects, so any benefit may come from relaxation rather than lymph flow. Results in this group may not apply to women with different cycle patterns or more severe symptoms.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 60 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Oct 2026

An estimate. Start dates often move.

Expected to finish

Jul 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 40 years

Sex

Female participants only

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Female participants aged 18-40 years * Having a regular menstrual cycle every 24-32 days during the last 6 months * Having symptom severity above the cut-off score determined according to the Premenstrual Syndrome Scale (PMSS) during the premenstrual period * Having premenstrual syndrome symptoms for at least the last 3 menstrual cycles * Being literate and having the cognitive ability to complete the questionnaires * Providing voluntary informed consent after being informed about the study Exclusion Criteria: * Having an irregular menstrual cycle, amenorrhea, or being in the menopausal period * Being pregnant or breastfeeding * Having a history of significant cardiovascular, respiratory, neurological, orthopedic, or metabolic disease * Regular use of medications that may affect the autonomic nervous system, pain, or sleep, such as antidepressants or beta-blockers * Having a condition that constitutes a contraindication to manual lymphatic drainage, such as acute infection, deep vein thrombosis, or advanced heart failure

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Conditions

The condition(s) this trial relates to.

Edema Pain premenstrual tension

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Premenstrual syndrome

How to take part

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  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

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Contacts and locations

Locations

  • Cappadocia University Cappadocia Vocational College, Physiotherapy Program

    Nevşehir, Turkey (Türkiye)

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