Radioactive therapy aims to stall prostate cancer spread without hormone drugs

NCT ID NCT05939414

Recruiting now Disease control Sponsor: Novartis Pharmaceuticals Source: ClinicalTrials.gov ↗

First seen Jun 24, 2026 · Last updated Aug 04, 2026 · Updated 3 times

Summary

This phase 3 trial tests a radioactive drug called lutetium-177 vipivotide tetraxetan in 450 men whose prostate cancer has returned and spread to a few spots after initial treatment. The drug targets a protein on cancer cells and delivers radiation directly to them. The goal is to see if it can delay the cancer from spreading further and postpone the need for hormone therapy, which often has tough side effects.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: lutetium-177 vipivotide tetraxetan (a radioactive drug that targets prostate cancer cells)
What this could lead to: If it works, this could offer a new way to control early-stage prostate cancer that has spread to a few spots, delaying the need for hormone therapy and helping men maintain quality of life longer.
What could go wrong: This is a large phase 3 trial, but the drug is radioactive and may cause side effects like fatigue or blood cell changes. It is not a cure, and it is unclear if it will work better than current options for all patients.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

metastatic prostate carcinoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

OLIGOMETASTATIC PROSTATE CANCER (OMPC)

Contacts and locations

Locations

Associated Med Professionals of NY
RECRUITING

Syracuse, New York, 13210, United States
BAMF Health
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Grand Rapids, Michigan, 49503, United States
Beth Israel Deaconess Med Ctr
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Boston, Massachusetts, 02215, United States
Blue Ridge Cancer Center
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Wytheville, Virginia, 24382, United States
Cancer Specialists of North Florida
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Jacksonville, Florida, 32256, United States
Carolina Urologic Research Center
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Myrtle Beach, South Carolina, 29572, United States
Dana Farber Cancer Institute
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Boston, Massachusetts, 02115, United States
Dayton Physicians
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Kettering, Ohio, 45409, United States
East Carolina University
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Greenville, North Carolina, 27858, United States
East Jefferson Hospital
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Metairie, Louisiana, 70006, United States
Highlands Oncology Group
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Fayetteville, Arkansas, 72703, United States
Johns Hopkins Kimmel Com Cancer Ctr
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Baltimore, Maryland, 21231, United States
Mary Bird Perkins Cancer Center
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Baton Rouge, Louisiana, 70809, United States
Mayo Clinic Rochester
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Rochester, Minnesota, 55905, United States
Memorial Sloan Kettering Cancer Ctr
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New York, New York, 10065, United States
Montefiore Hospital
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The Bronx, New York, 10467 2490, United States
Novartis Investigative Site
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CABA, Buenos Aires, C1426ANZ, Argentina
Novartis Investigative Site
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CABA, C1181ACH, Argentina
Novartis Investigative Site
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Caba, C1431FWO, Argentina
Novartis Investigative Site
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Darlinghurst, New South Wales, 2010, Australia
Novartis Investigative Site
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Herston, Queensland, 4029, Australia
Novartis Investigative Site
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Adelaide, South Australia, 5000, Australia
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Malvern, Victoria, 3144, Australia
Novartis Investigative Site
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Linz, 4020, Austria
Novartis Investigative Site
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Vienna, 1090, Austria
Novartis Investigative Site
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Aalst, 9300, Belgium
Novartis Investigative Site
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Ghent, 9000, Belgium
Novartis Investigative Site
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Wilrijk, 2610, Belgium
Novartis Investigative Site
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São Paulo, São Paulo, 01246 000, Brazil
Novartis Investigative Site
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Calgary, Alberta, T2N 5G2, Canada
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Halifax, Nova Scotia, B3H 2Y9, Canada
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London, Ontario, N6A 4G5, Canada
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Ottawa, Ontario, K1H 8L6, Canada
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Toronto, Ontario, M5G 2M9, Canada
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Montreal, Quebec, H2X 1R9, Canada
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Montreal, Quebec, H3T 1E2, Canada
Novartis Investigative Site
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Québec, Quebec, G1J 1Z4, Canada
Novartis Investigative Site
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Beijing, 100036, China
Novartis Investigative Site
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Guangzhou, 510060, China
Novartis Investigative Site
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Shanghai, 200127, China
Novartis Investigative Site
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Bogota, Cundinamarca, 110111, Colombia
Novartis Investigative Site
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Bogotá, 110131, Colombia
Novartis Investigative Site
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Ostrava, Poruba, 708 52, Czechia
Novartis Investigative Site
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Olomouc, 779 00, Czechia
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Prague, 150 06, Czechia
Novartis Investigative Site
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Saint-Cloud, Hauts De Seine, 92210, France
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Bordeaux, 33076, France
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Bron, 69677, France
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Clermont-Ferrand, 63011, France
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Rouen, 76038, France
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Saint-Herblain, 44805, France
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Munich, Bavaria, 81377, Germany
Novartis Investigative Site
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Cologne, North Rhine-Westphalia, 50937, Germany
Novartis Investigative Site
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Aachen, 52074, Germany
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Augsburg, 86179, Germany
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Berlin, 10249, Germany
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Essen, 45147, Germany
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Münster, 48149, Germany
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Rostock, 18057, Germany
Novartis Investigative Site
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Athens, 11528, Greece
Novartis Investigative Site
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Thessaloniki, 540 07, Greece
Novartis Investigative Site
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Debrecen, Hajdu Bihar Megye, 4032, Hungary
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Budapest, H 1122, Hungary
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Budapest, H-1083, Hungary
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Beersheba, 8457108, Israel
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Haifa, 3109601, Israel
Novartis Investigative Site
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Jerusalem, 9112001, Israel
Novartis Investigative Site
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Petah Tikva, 4941492, Israel
Novartis Investigative Site
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Tel Aviv, 6423906, Israel
Novartis Investigative Site
WITHDRAWN

Brescia, BS, 25123, Italy
Novartis Investigative Site
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Cona, FE, 44124, Italy
Novartis Investigative Site
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Genova, GE, 16132, Italy
Novartis Investigative Site
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Milan, MI, 20141, Italy
Novartis Investigative Site
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Rozzano, MI, 20089, Italy
Novartis Investigative Site
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Pisa, PI, 56126, Italy
Novartis Investigative Site
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Roma, RM, 00168, Italy
Novartis Investigative Site
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Negrar, VR, 37024, Italy
Novartis Investigative Site
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Kashiwa, Chiba, 277-8577, Japan
Novartis Investigative Site
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Sapporo, Hokkaido, 060-8648, Japan
Novartis Investigative Site
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Kobe, Hyōgo, 6500047, Japan
Novartis Investigative Site
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Yokohama, Kanagawa, 236-0004, Japan
Novartis Investigative Site
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Chuo Ku, Tokyo, 1040045, Japan
Novartis Investigative Site
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Fukuoka, 811-0213, Japan
Novartis Investigative Site
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Fukuoka, 812-0033, Japan
Novartis Investigative Site
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Fukuoka, 8128582, Japan
Novartis Investigative Site
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Fukushima, 9601295, Japan
Novartis Investigative Site
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Ishikawa, 9208641, Japan
Novartis Investigative Site
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Kyoto, 6068507, Japan
Novartis Investigative Site
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Petaling Jaya, Selangor, 46050, Malaysia
Novartis Investigative Site
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Kuala Lumpur, 59100, Malaysia
Novartis Investigative Site
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Mexico City, Mexico City, 14050, Mexico
Novartis Investigative Site
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Huxquilucan, 52763, Mexico
Novartis Investigative Site
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Amsterdam, 1066 CX, Netherlands
Novartis Investigative Site
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Singapore, 119074, Singapore
Novartis Investigative Site
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Singapore, 168583, Singapore
Novartis Investigative Site
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Bratislava, 83310, Slovakia
Novartis Investigative Site
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Košice, 041 91, Slovakia
Novartis Investigative Site
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Nitra, 949 01, Slovakia
Novartis Investigative Site
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Trenčín, 911 01, Slovakia
Novartis Investigative Site
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Granada, Andalusia, 18014, Spain
Novartis Investigative Site
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L'Hospitalet de Llobregat, Barcelona, 08907, Spain
Novartis Investigative Site
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Barcelona, Catalonia, 08025, Spain
Novartis Investigative Site
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El Palmar, Murcia, 30120, Spain
Novartis Investigative Site
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Barcelona, 08036, Spain
Novartis Investigative Site
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Madrid, 28040, Spain
Novartis Investigative Site
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Madrid, 28041, Spain
Novartis Investigative Site
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Seville, 41013, Spain
Novartis Investigative Site
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Valencia, 46010, Spain
Novartis Investigative Site
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Geneva, 1211, Switzerland
Novartis Investigative Site
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Lucerne, 6006, Switzerland
Novartis Investigative Site
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Zurich, 8063, Switzerland
Novartis Investigative Site
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Taipei, 10002, Taiwan
Novartis Investigative Site
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Taipei, 103616, Taiwan
Novartis Investigative Site
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Taipei, 11217, Taiwan
Novartis Investigative Site
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Taoyuan, 33305, Taiwan
Novartis Investigative Site
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Bristol, Avon, BS2 8ED, United Kingdom
Novartis Investigative Site
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Guildford, Surrey, GU2 7XX, United Kingdom
Novartis Investigative Site
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Coventry, CV2 2DX, United Kingdom
Novartis Investigative Site
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London, NW3 2QG, United Kingdom
Novartis Investigative Site
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London, SW3 6JJ, United Kingdom
Oregon Urology Institute
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Springfield, Oregon, 97477, United States
Piedmont Healthcare
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Atlanta, Georgia, 30318, United States
Profound Research LLC
WITHDRAWN

Royal Oak, Michigan, 48073, United States
Rio Grande Urology
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El Paso, Texas, 79912, United States
Rocky Mountain Cancer Centers
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Denver, Colorado, 80218, United States
St Louis University
RECRUITING

St Louis, Missouri, 63104, United States
Stanford University
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Palo Alto, California, 94304, United States
The Cancer Institute of Alexian Brothers
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Elk Grove, Illinois, 60007, United States
The Urology Center PC DBA UroHealth Partners
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Omaha, Nebraska, 68114, United States
UCSF
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San Francisco, California, 94115, United States
Unity Point Clinic
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Des Moines, Iowa, 50323, United States
Univ of Texas Southwest Med Center
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Dallas, Texas, 75390-9034, United States
University of Chicago
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Chicago, Illinois, 60637, United States
University of Kansas Hospital
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Kansas City, Kansas, 66160, United States
University of Maryland Medical Ctr
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Baltimore, Maryland, 21201, United States
VA Caribbean Healthcare System
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San Juan, 00921, Puerto Rico
VA Greater LA Healthcare System
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Los Angeles, California, 90073, United States
VA Palo Alto Health Care System
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Palo Alto, California, 94304-1207, United States
VA St Louis Health Care System
WITHDRAWN

St Louis, Missouri, 63106, United States
Vanderbilt University Medical Center
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Nashville, Tennessee, 37232, United States
Virginia Oncology Associates
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Norfolk, Virginia, 23502, United States
Wash U School of Medicine
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St Louis, Missouri, 63110, United States
William Beaumont Hospital
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Royal Oak, Michigan, 48073, United States
Woodlands Medical Specialists
RECRUITING

Pensacola, Florida, 32503, United States

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