Promising drug combo shows hope for slowing rare gut tumors

NCT ID NCT03972488

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tested whether adding Lutathera to standard octreotide treatment can delay tumor growth in people with advanced neuroendocrine tumors of the stomach, intestines, or pancreas. The trial involved 226 patients with fast-growing tumors (grades 2 and 3) who had not received prior treatment. Results focus on how long the cancer stays under control and tumor shrinkage rates.

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Conditions

The condition(s) this trial relates to.

digestive system neuroendocrine neoplasm digestive system neuroendocrine tumor, grade 1/2

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Contacts and locations

Locations

  • A.O.di Bologna Policl.S.Orsola

    Bologna, Italy

  • Arcispedale Santa Maria Nuova, Reggio Emilia - Oncology

    Reggio Emilia, Italy

  • Asan Medical Center - Oncology

    Seoul, South Korea

  • Azienda Ospedaliera Sant'Andrea - Università La Sapienza U.O.C. Mal App. Digerente e - Oncology

    Roma, Italy

  • BC Cancer Agency

    Vancouver, Canada

  • Bristol Haematology and Oncology Centre

    Bristol, United Kingdom

  • CHU Paris Nord-Val de Seine

    Clichy, France

  • CHU-Hôtel Dieu Service de Médecine Nucléaire

    Nantes, France

  • Centre Hospitalier Universitaire de Quebec

    Québec, Canada

  • Erasmus Medisch Centrum

    Rotterdam, Netherlands

  • Fondazione Irccs Istituto Nazionale Tumori

    Milan, Italy

  • Guys And St Thomas Hospital

    London, United Kingdom

  • Hospices Civils de Lyon (HCL) - Hopital Edouard Herriot

    Lyon, France

  • Hospital General Universitario Gregorio Marañón

    Madrid, Spain

  • Hospital Universitari i Politecnic La Fe

    Valencia, Spain

  • Hospital Universitario Ramón y Cajal

    Madrid, Spain

  • Hospital Universitario Vall d'Hebrón

    Barcelona, Spain

  • IRCCS fondazione Pascale - Oncology

    Naples, Italy

  • Ieo, Irccs

    Milan, Italy

  • Institut Gustave Roussy

    Villejuif, France

  • Institut du Cancer de Montpellier - Oncology

    Montpellier, France

  • Istituto Oncologico Romagnolo

    Meldola, Italy

  • Kings College Hospital - Oncology

    London, United Kingdom

  • London Health Sciences Centre, University of Western Ontario - Oncology

    London, Canada

  • MD Anderson Cancer Center

    Houston, Texas, 77030, United States

  • Mayo Clinic - Oncology

    Rochester, Minnesota, 55905, United States

  • Royal Free Hospital, London

    London, United Kingdom

  • Seoul National University Bundang Hospital

    Seongnam-si, South Korea

  • Seoul National University Hospital - Department of Internal Medicine

    Seoul, South Korea

  • Severance Hospital, Yonsei University Health System - Medical Oncology

    Seoul, South Korea

  • Sunnybrook Health Sciences Centre

    Toronto, Canada

  • UMC Utrecht - Oncology

    Utrecht, Netherlands

  • USF - H. Lee Moffitt Cancer Center and Research Institute

    Tampa, Florida, 33612, United States

  • University of Genova - Oncology

    Genova, Italy

  • University of Iowa Hospitals and Clinics - Oncology

    Iowa City, Iowa, 52242, United States

  • University of Kentucky UK Markey Cancer Center

    Lexington, Kentucky, 40536, United States

  • Universitätsklinikum Erlangen

    Erlangen, Germany

  • Universitätsklinikum Essen - Klinik für Nuklearmedizin

    Essen, Germany

  • Weston Park Hospital

    Sheffield, United Kingdom

  • Yale Cancer Center

    New Haven, Connecticut, 06520, United States