New hope for rare cancer: drug duo aims to slow tumor growth

NCT ID NCT06088290

Recruiting now Disease control Sponsor: PharmaMar Source: ClinicalTrials.gov ↗

First seen Sep 30, 2025 · Last updated May 01, 2026 · Updated 28 times

Summary

This study tests whether adding lurbinectedin to standard chemotherapy (doxorubicin) helps people with metastatic leiomyosarcoma, a rare cancer of smooth muscle, live longer without their cancer growing. About 450 adults who have not had prior treatment for their advanced disease will be randomly assigned to receive either the combination or doxorubicin alone. The main goal is to see if the combination delays cancer progression.

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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

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Study contacts

Contact

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Locations

Augusta University Georgia Cancer Center
RECRUITING

Augusta, Georgia, 30912, United States
Azienda Ospedaliera Universitaria Policlinico Paolo Giaccone
RECRUITING

Palermo, 90127, Italy
Azienda Ospedaliero - Universitaria San Luigi Gonzaga
RECRUITING

Orbassano, 10043, Italy
Azienda Ospedaliero-Universitaria Citta della Salute e della Scienza di Torino
COMPLETED

Torino, 10126, Italy
Azienda Ospedaliero-Universitaria di Bologna - Policlinico Sant Orsola-Malpighi
RECRUITING

Bologna, Italy
Cambridge University Hospitals NHS Foundation Trust
NOT_YET_RECRUITING

Cambridge, CB2 0QQ, United Kingdom
Cedars-Sinai Medical Center
NOT_YET_RECRUITING

Los Angeles, California, 90025, United States
Centre Antoine Lacassagne
RECRUITING

Nice, Provence-Alpes-Côte d'Azur Region, 06189, France
Centre Eugène Marquis
RECRUITING

Rennes, 35042, France
Centre Hospitalier Régional et Universitaire de Besançon - Hôpital Jean-Minjoz
RECRUITING

Besançon, Doubs, 25030, France
Centre Hospitalier Universitaire Dupuytren 1
RECRUITING

Limoges, 87042, France
Centre Hospitalier Universitaire Vaudois Lausanne
RECRUITING

Lausanne, 1011, Switzerland
Centre Hospitalier Universitaire de Poitiers
RECRUITING

Poitiers, 86000, France
Centre Léon Bérard
RECRUITING

Lyon, Auvergne-Rhône-Alpes, 69008, France
Centre de Lutte contre le Cancer - Centre Oscar Lambret
ACTIVE_NOT_RECRUITING

Lille, 59000, France
Centro di Riferimento Oncologico
RECRUITING

Aviano, 33081, Italy
Cleveland Clinic Main Campus
COMPLETED

Cleveland, Ohio, 44195, United States
Cliniques Universitaires Saint-Luc
RECRUITING

Brussels, 1200, Belgium
Complejo Hospitalario Universitario A Coruña
RECRUITING

A Coruña, 15006, Spain
Complejo Hospitalario Universitario de Santiago (CHUS)
RECRUITING

A Coruña, 15006, Spain
Dana-Farber Cancer Institute
RECRUITING

Boston, Massachusetts, 02215, United States
Fred Hutchinson Cancer Center - Seattle Cancer Care Alliance (SCCA) Location
RECRUITING

Seattle, Washington, 98109, United States
Gustave Roussy
RECRUITING

Villejuif, 94805, France
Helios Klinikum Bad Saarow
RECRUITING

Bad Saarow, 15526, Germany
Het Nederlands Kanker Instituut
RECRUITING

Amsterdam, North Holland, 1066 CX, Netherlands
Hospital Clínico San Carlos
RECRUITING

Madrid, 28040, Spain
Hospital Clínico Universitario de Valencia
RECRUITING

Valencia, 46010, Spain
Hospital General Universitario Gregorio Marañón
RECRUITING

Madrid, 28007, Spain
Hospital Universitari Vall d'Hebrón
RECRUITING

Barcelona, 08035, Spain
Hospital Universitari i Politècnic La Fe
RECRUITING

Valencia, 46026, Spain
Hospital Universitario Fundación Jiménez Díaz
RECRUITING

Madrid, 28040, Spain
Hospital Universitario La Paz
COMPLETED

Madrid, 28046, Spain
Hospital Universitario Miguel Servet
RECRUITING

Zaragoza, 50009, Spain
Hospital Universitario Virgen del Rocío
RECRUITING

Seville, 41013, Spain
Hospital Universitario de Canarias
NOT_YET_RECRUITING

San Cristóbal de La Laguna, 38320, Spain
Hospital de la Santa Creu i Sant Pau
RECRUITING

Barcelona, 08025, Spain
Hôspital de la Timone
COMPLETED

Marseille, 13005, France
Institut Bergonié
RECRUITING

Bordeaux, 33076, France
Institut Català d'Oncologia - Hospital Duran i Reynals (ICO L'Hospitalet)
RECRUITING

Barcelona, 08908, Spain
Institut Curie
RECRUITING

Paris, 75005, France
Institut Jules Bordet
RECRUITING

Anderlecht, 1070, Belgium
Institut de Cancérologie de l'Ouest - Angers
RECRUITING

Angers, Pays de la Loire Region, 49055, France
Institut de Cancérologie de l'Ouest - Saint-Herblain - Site René Gauducheau
RECRUITING

Saint-Herblain, 44805, France
Instituto Portugues De Oncologia De Lisboa Francisco Gentil
RECRUITING

Lisbon, Lisbon District, 1099-023, Portugal
Instituto Português de Oncologia do Porto Francisco Gentil
RECRUITING

Porto, 4200-072, Portugal
Istituto Nazionale Tumori IRCCS Fondazione G. Pascale
RECRUITING

Naples, Naples, 80131, Italy
Istituto Nazionale Tumori Regina Elena
RECRUITING

Roma, 00144, Italy
Istituto Oncologico Veneto - IRCCS
RECRUITING

Padova, 35128, Italy
Istituto Ortopedico Rizzoli
RECRUITING

Bologna, 40136, Italy
Istituto di Candiolo - Fondazione del Piemonte per l'Oncologia
RECRUITING

Candiolo, 10060, Italy
Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) - Istituto Clinico Humanitas
RECRUITING

Rozzano, Milan, 20089, Italy
LMU Klinikum - Campus Großhadern
RECRUITING

München, Bavaria, 81675, Germany
Leids Universitair Medisch Centrum (LUMC)
RECRUITING

Leiden, South Holland, 2333 ZA, Netherlands
Massachusetts General Hospital
RECRUITING

Boston, Massachusetts, 02114, United States
Mayo Clinic - Jacksonville
RECRUITING

Jacksonville, Florida, 32224, United States
Mayo Clinic - Rochester
RECRUITING

Rochester, Minnesota, 55905, United States
Mayo Clinic Hospital - Phoenix
RECRUITING

Phoenix, Arizona, 85054, United States
Medizinische Hochschule Hannover
RECRUITING

Hanover, 30625, Germany
Medizinische Universität Innsbruck
RECRUITING

Innsbruck, 6020, Austria
Medizinische Universität Wien
RECRUITING

Vienna, 1090, Austria
Memorial Sloan Kettering Cancer Center - New York
RECRUITING

New York, New York, 10065, United States
Moffitt Cancer Center
RECRUITING

Tampa, Florida, 33612, United States
Narodowy Instytut Onkologii im. Marii Skłodowskiej-Curie - Państwowy Instytut Badawczy
RECRUITING

Warsaw, Masovian Voivodeship, 02-781, Poland
Norris Comprehensive Cancer Center
RECRUITING

Los Angeles, California, 90033, United States
Ordensklinikum Linz GmbH Barmherzige Schwestern
NOT_YET_RECRUITING

Linz, 4010, Austria
Oregon Health and Science University
RECRUITING

Portland, Oregon, 97239, United States
Oxford University Hospitals NHS Foundation Trust
RECRUITING

Oxford, OX3 7LE, United Kingdom
Precision NextGen Oncology & Research Center
RECRUITING

Beverly Hills, California, 90212, United States
START Madrid - CIOCC - HM Sanchinarro
RECRUITING

Madrid, 28050, Spain
Sarcoma Oncology Center
RECRUITING

Los Angeles, California, 90057, United States
Stanford University (Leland Stanford Junior University)
RECRUITING

Palo Alto, California, 94304, United States
Szpitale Pomorskie Spółka Z Ograniczoną Odpowiedzialnością
RECRUITING

Gdynia, Pomeranian Voivodeship, 81-519, Poland
The Christie NHS Foundation Trust
RECRUITING

Manchester, M20 4BX, United Kingdom
The Clatterbridge Cancer Centre NHS Foundation Trust
RECRUITING

Liverpool, L7 8YA, United Kingdom
The Royal Marsden NHS Foundation Trust
RECRUITING

London, SW3 6JJ, United Kingdom
UT Southwestern Harold C. Simmons Comprehensive Cancer Center
RECRUITING

Dallas, Texas, 75390-8562, United States
Unidade Local de Saúde de Coimbra
NOT_YET_RECRUITING

Coimbra, 3000-075, Portugal
Unidade Local de Saúde de Santo António, E.P.E - Hospital Geral de Santo António
RECRUITING

Porto, 4050-342, Portugal
Universitaetsklinikum Graz - Universitätsklinik für Innere Medizin
RECRUITING

Graz, 8036, Austria
Universitair Ziekenhuis Bruseel
RECRUITING

Jette, Brussels Capital, 1090, Belgium
Universitair Ziekenhuis Leuven - Campus Gasthuisberg
RECRUITING

Leuven, 3000, Belgium
Universitatsklinikum Carl Gustav Carus Dresden
RECRUITING

Dresden, 01307, Germany
University College London Hospitals NHS Foundation Trust
RECRUITING

London, NW1 2BU, United Kingdom
University Hospital Birmingham NHS Foundation Trust
RECRUITING

Birmingham, B15 2GW, United Kingdom
University of Colorado Hospital - Anschutz Medical Campus
RECRUITING

Aurora, Colorado, 80045, United States
University of Michigan
RECRUITING

Ann Arbor, Michigan, 48109, United States
University of Pennsylvania Abramson Cancer Center
RECRUITING

Philadelphia, Pennsylvania, 19104, United States
University of Pittsburgh Medical Center (UPMC) Hillman Cancer Center
RECRUITING

Pittsburgh, Pennsylvania, 15232, United States
University of Texas MD Anderson Cancer Center
RECRUITING

Houston, Texas, 77030, United States
Università Campus Bio-Medico di Roma
RECRUITING

Roma, 00128, Italy
Universitätsklinikum Heidelberg
ACTIVE_NOT_RECRUITING

Heidelberg, 69120, Germany
Universitätsklinikum Münster
RECRUITING

Münster, 48149, Germany
Universitätsklinikum Tübingen
RECRUITING

Tübingen, 72016, Germany
Universitätsmedizin Mannheim
RECRUITING

Manheim, 68167, Germany
Universitätsspital Basel
COMPLETED

Basel, 4031, Switzerland
Vanderbilt - Ingram Cancer Center
RECRUITING

Nashville, Tennessee, 37232, United States
Washington University School of Medicine in St. Louis
RECRUITING

St Louis, Missouri, 63110, United States

Conditions

Explore the condition pages connected to this study.

LEIOMYOSARCOMA