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Could UV light make hepatitis b donor lungs safe for transplant?

NCT ID NCT07189377

Recruiting now Disease control Sponsor: University Health Network, Toronto Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests whether lungs from donors with hepatitis B can be safely given to people who do not have hepatitis B. The donated lungs are treated with UV light during a special preservation process, and recipients receive antiviral drugs and antibodies to prevent infection. Twenty lung transplant candidates will be enrolled to see if this approach prevents transmission of the virus.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
Entecavir (antiviral drug), HBIG (antibodies), and UV light treatment of the donor lung
What this could lead to
If successful, this could safely expand the pool of donor lungs for transplant, reducing wait times for people needing a lung transplant.
What could go wrong
This is a small early safety trial with only 20 participants, so results may not apply broadly. There is a risk of hepatitis B transmission despite treatment, and side effects from the antiviral drugs.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

hepatitis B virus infection prevention target

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

HEPATITIS B VIRUS (HBV) LUNG TRANSPLANT RECIPIENT

Contacts and locations

Locations

  • University Health Network, Toronto General Hospital

    RECRUITING

    Toronto, Ontario, M5G 2C4, Canada

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