Could UV light make hepatitis b donor lungs safe for transplant?
NCT ID NCT07189377
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tests whether lungs from donors with hepatitis B can be safely given to people who do not have hepatitis B. The donated lungs are treated with UV light during a special preservation process, and recipients receive antiviral drugs and antibodies to prevent infection. Twenty lung transplant candidates will be enrolled to see if this approach prevents transmission of the virus.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Entecavir (antiviral drug), HBIG (antibodies), and UV light treatment of the donor lung
What this could lead to
If successful, this could safely expand the pool of donor lungs for transplant, reducing wait times for people needing a lung transplant.
What could go wrong
This is a small early safety trial with only 20 participants, so results may not apply broadly. There is a risk of hepatitis B transmission despite treatment, and side effects from the antiviral drugs.
Disclaimer
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This is a summary of
the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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University Health Network, Toronto General Hospital
RECRUITINGToronto, Ontario, M5G 2C4, Canada
Contact Phone: •••-•••-•••• Email: •••••@•••••