New mRNA vaccine combo aims to prevent lung cancer recurrence in High-Risk patients
NCT ID NCT07513376
First seen Jun 27, 2026 · Last updated Aug 14, 2026 · Updated 11 times
Summary
This phase 3 trial tests whether a personalized mRNA cancer vaccine (intismeran) alone or combined with an immunotherapy drug (pembrolizumab) can prevent non-small cell lung cancer from coming back after complete surgical removal. About 876 people with high-risk stage I lung cancer will be randomly assigned to receive the vaccine, the combination, or a placebo. The study aims to see if these treatments improve disease-free survival compared to placebo.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- intismeran (mRNA cancer vaccine) and pembrolizumab (immunotherapy)
- What this could lead to
- If successful, this could offer a new way to prevent early-stage lung cancer from coming back after surgery, potentially improving long-term survival.
- What could go wrong
- This is a large phase 3 trial, but the treatment is experimental. It may not work better than placebo, and side effects from immunotherapy or the vaccine could be serious.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Email: •••••@•••••
Locations
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Altru Health System ( Site 3254)
RECRUITINGGrand Forks, North Dakota, 58201, United States
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Ankara Bilkent Sehir Hastanesi ( Site 4306)
RECRUITINGAnkara, 6800, Turkey (Türkiye)
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Atatürk Göğüs Hastalıkları Ve Göğüs Cerrahisi Eğitim Araştırma Hastanesi ( Site 4309)
RECRUITINGAnkara, 6280, Turkey (Türkiye)
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Augusta-Kranken-Anstalt ( Site 2702)
RECRUITINGBochum, North Rhine-Westphalia, 44791, Germany
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Avera Cancer Institute ( Site 3209)
RECRUITINGSioux Falls, South Dakota, 57105, United States
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Azienda Ospedaliero Universitaria Maggiore della Carità ( Site 2803)
RECRUITINGNovara, 28100, Italy
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Bacs-Kiskun Varmegyei Oktatokorhaz ( Site 4406)
RECRUITINGKecskemét, Bács-Kiskun county, 6000, Hungary
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Billings Clinic ( Site 3255)
RECRUITINGBillings, Montana, 59101, United States
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Borsod-Abaúj-Zemplén Vármegyei Központi Kórház És Egyetemi Oktatókórház ( Site 4409)
RECRUITINGMiskolc, Borsod-Abauj Zemplen county, 3526, Hungary
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Centre Hospitalier de l'Université de Montréal ( Site 2501)
RECRUITINGMontreal, Quebec, H2X 3E4, Canada
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Chang Gung Memorial Hospital at Kaohsiung ( Site 5302)
RECRUITINGKaohsiung City, 83301, Taiwan
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China Medical University Hospital ( Site 5303)
RECRUITINGTaichung, 40447, Taiwan
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Erciyes Universitesi Tıp Fakultesi Hastaneleri ( Site 4304)
RECRUITINGKayseri, 38039, Turkey (Türkiye)
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Errikos Dunant Hospital Center ( Site 5004)
RECRUITINGAthens, Attica, 115 26, Greece
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European Interbalkan Medical Center-Oncology Department ( Site 5000)
RECRUITINGThessaloniki, 570 01, Greece
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Fondazione IRCCS Istituto Nazionale Dei Tumori ( Site 2800)
RECRUITINGMilan, Lombardy, 20133, Italy
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Frisius Medisch Centrum ( Site 4808)
RECRUITINGLeeuwarden, Provincie Friesland, 8934 AD, Netherlands
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HOSPITAL GENERAL UNIVERSITARIO GREGORIO MARAÑON ( Site 0307)
RECRUITINGMadrid, 28009, Spain
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Hacettepe Universite Hastaneleri-oncology hospital ( Site 4300)
RECRUITINGAnkara, 6230, Turkey (Türkiye)
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Hadassah Medical Center ( Site 3305)
RECRUITINGJerusalem, 9112001, Israel
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Hamilton Health Sciences-Juravinski Cancer Centre ( Site 2506)
RECRUITINGHamilton, Ontario, L8V 5C2, Canada
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Hospital Clinico San Carlos ( Site 0303)
RECRUITINGMadrid, 28040, Spain
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Hospital Universitario Virgen Macarena ( Site 0306)
RECRUITINGSeville, 41007, Spain
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Hospital Virgen de la Victoria ( Site 0309)
RECRUITINGMálaga, Malaga, 29010, Spain
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Hospital de Cruces ( Site 0308)
RECRUITINGBarakaldo, Bizkaia, 48903, Spain
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IP Clinic ( Site 4204)
RECRUITINGLodz, Łódź Voivodeship, 90-752, Poland
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Kingston Health Sciences Centre-Kingston General Hospital Site ( Site 2503)
RECRUITINGKingston, Ontario, K7L 2V7, Canada
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Meander Medisch Centrum ( Site 4802)
RECRUITINGAmersfoort, Utrecht, 3813 TZ, Netherlands
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Meir medical center ( Site 3306)
RECRUITINGKfar Saba, 4428164, Israel
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NHO Revive Research Institute, LLC ( Site 3218)
RECRUITINGLincoln, Nebraska, 68506, United States
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National Cheng Kung University Hospital ( Site 5300)
RECRUITINGTainan, 704, Taiwan
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One Clinical Research ( Site 0501)
RECRUITINGNedlands, Western Australia, 6009, Australia
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Országos Onkológiai Intézet ( Site 4405)
RECRUITINGBudapest, 1122, Hungary
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Pecsi Tudomanyegyetem Klinikai Kozpont ( Site 4401)
RECRUITINGPécs, Baranya, 7623, Hungary
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Radboudumc ( Site 4806)
RECRUITINGNijmegen, Gelderland, 6525 GA, Netherlands
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Rambam Health Care Campus ( Site 3303)
RECRUITINGHaifa, 3109601, Israel
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Reformatus Pulmonologiai Centrum ( Site 4403)
RECRUITINGTörökbálint, Pest County, 2045, Hungary
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Renown Regional Medical Center-Renown Health Medical Oncology ( Site 3207)
RECRUITINGReno, Nevada, 89502, United States
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Royal North Shore Hospital ( Site 0502)
RECRUITINGSt Leonards, New South Wales, 2065, Australia
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Shaare Zedek Medical Center ( Site 3301)
RECRUITINGJerusalem, 9103102, Israel
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Sheba Medical Center ( Site 3302)
RECRUITINGRamat Gan, 5265601, Israel
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Singleton Hospital ( Site 0403)
RECRUITINGSwansea, SA2 8QA, United Kingdom
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Smilow Cancer Center at Yale-New Haven ( Site 3253)
RECRUITINGNew Haven, Connecticut, 06511, United States
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THORACIC GENERAL HOSPITAL OF ATHENS "I SOTIRIA" ( Site 5001)
RECRUITINGAthens, Attica, 115 27, Greece
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Taichung Veterans General Hospital ( Site 5301)
RECRUITINGTaichung, 407, Taiwan
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Taipei Medical University Hospital ( Site 5305)
RECRUITINGTaipei, 110, Taiwan
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The University of Tennessee Medical Center ( Site 3223)
RECRUITINGKnoxville, Tennessee, 37920, United States
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University General Hospital ''Attikon'' - General Hospital of West Attica "H AGIA VARVARA" ( Site 5003)
RECRUITINGChaïdári, Attica, 124 62, Greece
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University Medical Center Groningen ( Site 4807)
RECRUITINGGroningen, 9713 GZ, Netherlands
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WakeMed Raleigh Campus ( Site 3214)
RECRUITINGRaleigh, North Carolina, 27610, United States
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West Virginia University ( Site 3237)
RECRUITINGMorgantown, West Virginia, 26506, United States
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White Plains Hospital ( Site 3213)
RECRUITINGWhite Plains, New York, 10601, United States
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Wielkopolskie Centrum Pulmonologii i Torakochirurgii ( Site 4202)
RECRUITINGPoznan, Greater Poland Voivodeship, 60-569, Poland
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Wojewodzki Szpital Specjalistyczny im. sw. Rafala w Czerwonej Gorze ( Site 4206)
RECRUITINGChęciny, Świętokrzyskie Voivodeship, 26-060, Poland
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Ziekenhuis St. Jansdal ( Site 4800)
RECRUITINGHarderwijk, Gelderland, 3844 DG, Netherlands
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İstinye Üniversitesi Liv Hospital-Topkapi ( Site 4307)
RECRUITINGIstanbul, 34010, Turkey (Türkiye)
More trials for these conditions
Other studies related to the condition(s) this trial covers.
- Can a new immunotherapy combo outsmart advanced lung cancer?
- Double attack on mutant KRAS: can two targeted drugs outsmart resistant cancers?
- Seeing the fight: new imaging tracer may reveal how immune cells attack lung cancer
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- Can a PET scan reveal hidden heart harm from lung cancer treatment?