New drug cocktail aims to outperform standard lung cancer therapy

NCT ID NCT06984588

Ongoing Disease control Sponsor: TJ Biopharma Co., Ltd. Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tests whether a new drug combination (uliledlimab plus toripalimab) works better than the standard immunotherapy pembrolizumab for people with advanced non-small cell lung cancer that hasn't been treated yet. The trial includes 450 participants whose tumors have specific markers (PD-L1 and CD73). The goal is to see if the new combo can delay cancer growth better than current options.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance

uliledlimab combined with toripalimab

What this could lead to

If successful, this combination could offer a new first-line treatment option for people with a specific type of advanced lung cancer, potentially improving how long they live without their cancer growing.

What could go wrong

This is an early-to-mid stage trial, so the new combination may not work better than existing treatments. It also only includes patients with certain genetic markers, so results may not apply to everyone with lung cancer.

Disclaimer Read more

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

Get updates

Get notified about this study

Our safety recommendation!

By submitting, you agree to our Terms of use

Conditions

The condition(s) this trial relates to.

non-small cell lung carcinoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

NON-SMALL-CELL LUNG CANCER

Contacts and locations

Show contact details

Locations

Affiliated Hospital of Jining Medical University

Jining, China
Anhui provincial cancer hospital

Hefei, China
Anyang Tumour Hospital

Anyang, China
Army characteristic Hospital Center( Daping Hospital of the Third Military Medical University)

Chongqing, China
Beijing Chest Hospital, Capital Medical University

Beijing, China
Bejing Chao-Yang Hospital, Capital Medical University

Beijing, China
Binzhou Medical University Hospital

Binzhou, China
China Shenyang the Tenth People's Hospital(China Shenyang Chest Hospital)

Shenyang, China
Chongqing University Cancer Hospital

Chongqing, China
Chongqing University Three Gorges Hospital

Chongqing, China
First Affiliated Hospital of Gannan Meidcal University

Ganzhou, China
First Hospital of Shanxi Medical University

Taiyuan, China
Fujian Provincial Cancer Hospital

Xiamen, China
Ganzhou People's Hospital

Ganzhou, China
Guangdong Provincial People's Hospital

Guangzhou, China
Guangxi Medical University Cancer Hospital

Nanning, China
Guizhou Provincial People's Hospital

Guiyang, China
Harbin Medical university cancer hospital

Ha’erbin, China
Jiamusi Tumour Hospital

Jiamusi, China
Jiangmen Central hospital

Jiangmen, China
Jiangsu Province Hospital

Nanjing, China
Jiangxi Cancer Hospital

Nanchang, China
Jinan Central Hospital

Jinan, China
Linyi People's Hospital

Linyi, China
Lishui Central Hospital

Lishui, China
Liuzhou Central Hospital

Liuzhou, China
Longyan First Hospital

Longyan, China
Nanchong Central Hospital

Nanchong, China
Nantong Tumor Hospital

Nantong, China
Nanyang Cenreal Hospital

Nanyang, China
Northern Jiangsu People's Hospital

Yangzhou, China
Qingdao Central Hospital

Qingdao, China
Shanxi Yuncheng Central hospital

Yuncheng, China
Suining Central Hospital

Suining, China
Taizhou Hospital of Zhejiang Province

Taizhou, China
The First Affiliated Hospital Of Henan University Of Science & Technology

Zhengzhou, China
The First Affiliated Hospital Of Nanchang University

Nanchang, China
The First Affiliated Hospital Of Xiamen University

Xiamen, China
The First Affiliated Hospital Of Zhengzhou University

Zhengzhou, China
The First Affiliated Hospital of Anhui Medical University

Hefei, China
The First Affiliated Hospital of Bengbu Medical University

Bengbu, China
The First Affiliated Hospital of Guangxi Medical University

Nanning, China
The First Affiliated Hospital of Xi'an Jiaotong University

Xi'an, China
The First People's Hospital Of Qujing

Qujing, China
The Fourth Hospital Of Hebei Medical University

Shijia Zhuang, China
The People's Hospital of Dongguan

Dongguan, China
The Second Affiliated Hospital Of Xi'an Jiaotong University

Xi'an, China
The Second Affiliated Hospital of Hainan Medical University

Haikou, China
The Second Affiliated Hospital of Xiamen Medical College

Xiamen, China
The Second People's Hospital Of Yibin

Yibin, China
The Second People's Hospital of Neijiang

Neijiang, China
The Third Xiangya Hospital of Central South University

Changsha, China
The first people's hospital of Foshan

Foshan, China
The first people's hospital of Zunyi

Zunyi, China
Tianjin Medical University Cancer Institute & Hospital

Tianjin, China
Union Hospital affiliated to Tongji Medical College of Huazhong University of Science and Technology

Wuhan, China
Xi'an Chest Hospital

Xi'an, China
Xiangya Hospital of Central South University

Changsha, China
Xiangyang Central Hospital

Xiangyang, China
Yichang Central People's Hospital

Yichang, China
Yuebei People's Hospital

Shaoguan, China
Zhoukou Central hospital

Zhoukou, China
Zhujiang hospital of Southern Medical University

Zhujiang, China
Zibo Municipal Hospital

Zibo, China