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New hope for Hard-to-Treat lung cancer: which combo works best?

NCT ID NCT05689671

Ongoing Disease control Sponsor: Nikolaj Frost MD Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests two different chemotherapy plus immunotherapy combinations in people with advanced lung cancer that has a specific marker (TTF-1 negative). About 136 participants will be randomly assigned to one of two treatment groups. The goal is to see which combination helps people live longer and controls the cancer better.

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Conditions

The condition(s) this trial relates to.

non-small cell lung carcinoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

NON-SMALL CELL LUNG CANCER METASTATIC

Contacts and locations

Locations

  • Asklepios Klinik Gauting GmbH

    Gauting, 82131, Germany

  • Asklepios Klinkum Hamburg

    Hamburg, 21075, Germany

  • Barmherzige Brüder Krankenhaus Regensburg

    Regensburg, 93049, Germany

  • Charité Universitätsmedizin

    Berlin, 13353, Germany

  • Elblandkliniken Stiftung & Co. KG Elblandklinikum Riesa

    Riesa, 01589, Germany

  • Evangelische Lungenklinik

    Berlin, 13125, Germany

  • Evangelische Lungenklinik Krankenhausbetriebs gGmbH

    Berlin, 13125, Germany

  • Helios Klinikum Emil von Behring

    Berlin, 14165, Germany

  • Helios Klinikum Krefeld

    Krefeld, 47805, Germany

  • KEM Evang. Kliniken Essen-Mitte

    Essen, 45136, Germany

  • Kliniken der Stadt Köln GmbH

    Cologne, 51109, Germany

  • Klinikum Bielefeld

    Bielefeld, 33604, Germany

  • Klinikum Esslingen GmbH

    Esslingen am Neckar, 73730, Germany

  • Klinikum Lippe GmbH

    Lemgo, 32657, Germany

  • Klinikum Ludwigsburg

    Ludwigsburg, 71640, Germany

  • Klinikum St. Marien

    Amberg, 92224, Germany

  • Klinikum Stuttgart

    Stuttgart, 70174, Germany

  • Krankenhaus Nordwest

    Frankfurt, 60488, Germany

  • LMU Klinikum

    München, 80336, Germany

  • LungenClinic Großhansdorf GmbH

    Großhansdorf, 22927, Germany

  • Lungenklinik Hemer

    Hemer, 58675, Germany

  • MVZ Taunus GmbH

    Bad Homburg, 61352, Germany

  • MVZ für Hämatologie und Onkologie Ravensburg GmbH

    Ravensburg, 88212, Germany

  • Medizinische Fakultät Mannheim der Universität Heidelberg

    Mannheim, 68167, Germany

  • Pius Hospital

    Oldenburg, 26121, Germany

  • Technische Universität Dresden Medizinische Fakultät Carl Gustav Carus

    Dresden, 01307, Germany

  • Thoraxklinik Heidelberg gGmbH

    Heidelberg, 69126, Germany

  • Thoraxzentrum Ruhrgebiet Ev. Krankenhaus Herne

    Herne, 44651, Germany

  • UKSH, Campus Lübeck

    Lübeck, 23538, Germany

  • Universitätsklinikum Augsburg

    Augsburg, 86156, Germany

  • Universitätsklinikum Essen

    Essen, 45122, Germany

  • Universitätsklinikum Frankfurt am Main

    Frankfurt am Main, 60590, Germany

  • Universitätsmedizin Göttingen

    Göttingen, 37075, Germany

  • Unversitätsklinikum Münster

    Münster, 48149, Germany

  • ÜBAG- Medizinisches Versorgungszentrum Dr. Vehling-Kaiser GmbH

    Landshut, 84036, Germany

  • Überörtliche Gemeinschaftspraxis für Hämatologie und Onkologie

    Münster, 48153, Germany

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