Surgery before chemo and immunotherapy may boost lung cancer outcomes
NCT ID NCT07177105
First seen Jun 25, 2026 · Last updated Jun 26, 2026 · Updated 1 time
Summary
This study looks at whether surgically removing the primary lung tumor before giving immunotherapy (sintilimab) and chemotherapy can improve outcomes for people with advanced non-small cell lung cancer that is not driven by EGFR or ALK mutations. About 118 participants will be randomly assigned to either receive surgery followed by the drug combination, or the drugs alone. The main goal is to see if the surgery helps delay cancer progression or improve survival.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
sintilimab, pemetrexed, carboplatin, and cytoreductive surgery
What this could lead to
If successful, this could show that removing the primary tumor before immunotherapy and chemotherapy helps people with advanced lung cancer live longer without their disease getting worse.
What could go wrong
This is a Phase 2 trial with only 118 participants, so results are preliminary. Surgery in advanced cancer carries risks like infection or complications, and the added benefit over standard treatment is not yet proven.
Disclaimer
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
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