Lung cancer drug combo trial halted early

NCT ID NCT06897579

Terminated Disease control Sponsor: Chia Tai Tianqing Pharmaceutical Group Co., Ltd. Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tested a new combination of cancer drugs (bemarituzumab plus anlotinib) against a standard treatment (tislelizumab) for people with extensive-stage small cell lung cancer. The goal was to see if the new combo could delay cancer growth or improve survival. However, the trial was terminated early after enrolling only 40 participants, so the results are limited and not conclusive.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Carboplatin, cisplatin, etoposide, benmelstobart, anlotinib, tislelizumab
What this could lead to: If successful, this could point toward a more effective first-line treatment for extensive-stage small cell lung cancer.
What could go wrong: The trial was terminated early with only 40 participants, so it is too small and incomplete to draw reliable conclusions. The drug combination also carries risks like immune-related side effects.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

small cell lung carcinoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

EXTENSIVE-STAGE SMALL CELL LUNG CANCER

Contacts and locations

Locations

Baotou Cancer Hospital

Baotou, Inner Mongolia, 014000, China
Beijing Cancer Hospital

Beijing, Beijing Municipality, 100142, China
Cancer Hospital Chinese Academy of Medical Sciences

Beijing, Beijing Municipality, 100000, China
Cancer Hospital of Shantou University Medical College

Shantou, Guangdong, 510000, China
Dongyang Municipal People's Hospital

Dongyang, Zhejiang, 522031, China
Fujian Medical University 2nd Affiliated Hospital

Quanzhou, Fujian, 362001, China
Henan Cancer Hospital Affiliated Cancer Hospital of Zhengzhou University

Zhengzhou, Henan, 457000, China
Henan Provincial People'S Hospital

Zhengzhou, Henan, 450003, China
Huazhong University of Science and Technology Tongji Medical College of Huazhong University of Science and Technology

Wuhan, Hubei, 430000, China
Jiangsu Cancer Hospital

Nanjing, Jiangsu, 210009, China
Jingzhou Central Hospital

Jingzhou, Hubei, 434000, China
Liaoning Cancer Hospital & Institute

Shenyang, Liaoning, 110000, China
Linyi City People's Hospital

Linyi, Shandong, 276003, China
Maanshan People's Hospital

Maanshan, Anhui, 243000, China
Nanfang Hospital

Guangzhou, Guangzhou, 510515, China
Ningbo Medical Center Lihuili Hospital

Ningbo, Zhejiang, 315000, China
Ningbo No.2 Hospital

Ningbo, Zhejiang, 315010, China
Peking University People´s Hospital

Beijing, Beijing Municipality, 100044, China
Shanxi Cancer hospital

Taiyuan, Shanxi, 30000, China
Shenyang Tenth People's Hospital

Shenyang, Liaoning, 110044, China
Sichuan cancer hospital

Chengdu, Sichuan, 610042, China
Taizhou Hospital of Zhejiang Province

Taizhou, Zhejiang, 317000, China
Tangshan People's Hospital

Tangshan, Hebei, 063001, China
The First Affiliated Hospital of China Medical University

Shenyang, Liaoning, 110000, China
The First Affiliated Hospital of Harbin Medical University

Harbin, Heilongjiang, 150000, China
The First Affiliated Hospital of Jinzhou Medical University

Jinzhou, Liaoning, 121001, China
The First Affiliated Hospital of Shandong First Medical University

Jinnan, Shandong, 250000, China
The Second Affiliated Hospital Of Xi'an Jiaotong University

Xi'an, Shannxi, 710000, China
The Second Hospitai. & Clinicae Medical School . Lanzhou University

Lanzhou, Gansu, 730030, China
The Second People's Hosital of Jiaozuo

Jiaozuo, Henan, 454001, China
The Second Xiangya Hospital of Central South University

Changsha, Hunan, 410011, China
The fourth hospital of hebei medical university

Shijiazhuang, Hebei, 05000, China

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