Could ketamine and lidocaine replace opioids for Post-Surgery pain?
NCT ID NCT07213687
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This completed study tested whether a combination of low-dose ketamine and lidocaine can control pain after gynecologic surgery as well as the opioid fentanyl, but with fewer side effects. Seventy adult women undergoing elective surgery were randomly assigned to receive either the ketamine-lidocaine combo or fentanyl during anesthesia. Researchers measured pain scores, nausea, vomiting, and recovery quality up to 24 hours after surgery.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
low-dose ketamine and lidocaine
What this could lead to
If effective, this drug combination could offer a way to manage post-surgery pain with fewer opioid-related side effects like nausea.
What could go wrong
This is a small, single-center trial with only 70 participants. Results may not apply to other surgeries or populations, and the combination may not outperform fentanyl.
Disclaimer
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This is a summary of
the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Dilla University
Awasa, Snnpr, 13, Ethiopia