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New drug shows promise for rare skin disease over nearly 5 years

NCT ID NCT03886246

Ongoing Disease control Sponsor: LEO Pharma Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Aug 04, 2026 · Updated 4 times

Summary

This study looks at the long-term safety and effectiveness of spesolimab in people with generalized pustular psoriasis (GPP), a rare and severe skin condition. All 131 participants had already taken spesolimab in a previous study and will continue treatment for up to 5 years. Researchers will monitor side effects and how quickly symptoms improve during flare-ups.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
spesolimab
What this could lead to
If successful, this could confirm spesolimab as a safe long-term treatment to control GPP flares and improve symptoms.
What could go wrong
This is a Phase 2 open-label study with no placebo group, so results may not prove effectiveness definitively. Long-term safety data is still being collected.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

generalized pustular psoriasis psoriasis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

GENERALIZED PUSTULAR PSORIASIS

Contacts and locations

Locations

  • Chang Gung Medical Foundation (CGMF) - Linkou Bran

    Linkou District, 333, Taiwan

  • Charité - Universitätsmedizin Berlin

    Berlin, 10117, Germany

  • Cliniques Universitaires Saint-Luc

    Brussels, 1200, Belgium

  • Clínica Dermacross S.A.

    Vitacura, 7640881, Chile

  • FSBEI HE "Kirov State Medical University"

    Kirov, 610035, Russia

  • Fachklinik Bad Bentheim

    Bad Bentheim, 48455, Germany

  • Farhat Hached Hospital

    Sousse, 4000, Tunisia

  • HCMC Hospital of Dermato-Venereology-Ho Chi Minh-66092

    Ho Chi Minh City, 70000, Vietnam

  • HOP Robert Debré

    Reims, 51092, France

  • HOP Saint-André

    Bordeaux, 33000, France

  • HOP Saint-Louis

    Paris, 75010, France

  • Hedi Chaker Hospital, Department of Dermatology

    Tunisia, 1053, Tunisia

  • Hospital Italiano de Buenos Aires

    CABA, C1199ABD, Argentina

  • Hospital Kuala Lumpur

    Kuala Lumpur, 50586, Malaysia

  • Hospital Pakar Sultanah Fatimah

    Muar town, 84000, Malaysia

  • Hospital Pulau Pinang-Pulau Pinang-21953

    George Town, 10990, Malaysia

  • Hospital Raja Permaisuri Bainun

    Ipoh, 30450, Malaysia

  • Hospital Sant Joan de Déu

    Esplugues Del Llobregat, 08950, Spain

  • Hospital Selayang

    Kuala Selangor, 68100, Malaysia

  • Hospital Sultan Ismail

    Johor Bahru, 81100, Malaysia

  • Hospital Sultanah Aminah

    Johor Bahru, 80100, Malaysia

  • Hospital Universitario Dr Jose Eleuterio Gonzalez

    Monterrey, 64460, Mexico

  • Huashan Hospital, Fudan University

    Shanghai, 200040, China

  • Hôpital de l'Archet

    Nice, 06200, France

  • Icahn School of Medicine at Mount Sinai

    New York, New York, 10029, United States

  • Iloilo Doctors Hospital

    Iloilo City, Iloilo, 5000, Philippines

  • Institute of Dermatology

    Bangkok, 10400, Thailand

  • Istituto Clinico Humanitas

    Rozzano (MI), 20089, Italy

  • Klinikum Oldenburg AöR

    Oldenburg, 26133, Germany

  • Klinikum der Universität München - Campus Innenstadt

    München, 80337, Germany

  • LLC "Medical Center Azbuka Zdorovia"

    Kazan', 420111, Russia

  • LLC Skin Disease Clinic of Pier Volkenstein, St. Petersburg

    Saint Petersburg, 190123, Russia

  • La Rabta Hospital

    Tunis, 1007, Tunisia

  • Marmara Universitesi Pendik Egitim ve Arastirma Hastanesi

    Istanbul, 34890, Turkey (Türkiye)

  • Nagoya City University Hospital

    Aichi, Nagoya, 467-8602, Japan

  • National Hospital of Dermatology and Venereology

    Hà Nội, 10000, Vietnam

  • National Taiwan University Hospital

    Taipei, 10002, Taiwan

  • Oakland Hills Dermatology

    Auburn Hills, Michigan, 48326, United States

  • Queen Elizabeth Hospital

    Kota Kinabalu, 88586, Malaysia

  • Ramathibodi Hospital

    Bangkok, 10400, Thailand

  • SBHI Chelyabinsk Reg.Clin.Derma.Dispen.

    Chelyabinsk, 454048, Russia

  • Saitama Medical University Hospital

    Saitama, Iruma-gun, 350-0495, Japan

  • Saratov State Med.Univ.n.a.Razumovskogo

    Saratov, 410028, Russia

  • Sarawak General Hospital

    Kuching, Sarawak, 93586, Malaysia

  • Second Affiliated Hospital of Xi'an JiaoTong University

    Xi'an, 710004, China

  • Severance Hospital

    Seoul, 03722, South Korea

  • Shanghai Skin Disease Hospital

    Shanghai, 200000, China

  • Singapore General Hospital

    Singapore, 169608, Singapore

  • Southern Philippines Medical Center -Davao-62091

    Davao City, 8000, Philippines

  • Sun yet-sen Memorial Hospital, Sun yet-sen Univesity

    Guangzhou, 510288, China

  • The Second Affiliated Hospital Zhejiang University School of Medicine

    Hangzhou, 310009, China

  • Tokyo Medical University Hachioji Medical Center

    Tokyo, Hachioji, 193-0998, Japan

  • Tokyo Medical University Ibaraki Medical Center

    Ibaraki, Inashiki-gun, 300-0395, Japan

  • Universitätsklinikum Bonn AöR

    Bonn, 53127, Germany

  • Universitätsklinikum Erlangen

    Erlangen, 91054, Germany

  • Universitätsklinikum Frankfurt

    Frankfurt am Main, 60596, Germany

  • Westfälische Wilhelms-Universität Münster

    Münster, 48149, Germany

  • Zenith Skin Science Center Inc.

    Makati City, 1229, Philippines

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