New hope for kids with rare liver disease: long-term drug study launched

NCT ID NCT05035030

Ongoing Symptom relief Sponsor: Albireo, an Ipsen Company Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jul 02, 2026 · Updated 1 time

Summary

This study looks at the long-term safety and effectiveness of odevixibat in 70 people with Alagille syndrome, a rare genetic condition that affects the liver and other organs. The drug aims to reduce severe itching and improve bile flow. Participants who completed a prior 24-week study can join this extension to see how well the treatment works over time.

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Conditions

The condition(s) this trial relates to.

Alagille syndrome

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ALAGILLE SYNDROME

Contacts and locations

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Locations

AOU Meyer

Florence, Italy
Antenne pediatrique du CIC-Hopital Jeanne De Flandre

Lille, France
Atrium Health Carolinas Medical

Durham, North Carolina, 27710, United States
Azienda Ospedale University

Padova, 35128, Italy
Birmingham Women's and Children's NHS Foundation Trust

Birmingham, United Kingdom
Boston Children's Hospital

Boston, Massachusetts, 02115, United States
Charité - Universitätsmedizin Berlin

Berlin, 13353, Germany
Children's Healthcare of Atlanta

Atlanta, Georgia, 30329, United States
Children's Mercy Hospital and Clinics

Kansas City, Missouri, 64018, United States
Childrens Medical Center of Dallas University of Texas Southwestern

Dallas, Texas, 75207, United States
Cincinnati Children's Hospital

Cincinnati, Ohio, 45229, United States
Cliniques Universitaires Saint-Luc Bruxelles

Brussels, 1200, Belgium
Hassenfeld Children's Hospital at NYU Langone

New York, New York, 10016, United States
Hopital Necker Enfants Malades

Paris, 75015, France
Hôpital Femme Mère Enfant de Lyon

Bron, 69677, France
Instytut Pomnik-Centrum Zdrowia Dzieck

Warsaw, 04-730, Poland
Istanbul University Istanbul Medical Faculty Hospital

Istanbul, Turkey (Türkiye)
Johns Hopkins Hospital

Baltimore, Maryland, 21287, United States
King's College Hospital NHS Foundation Trust King's College Hospital Paediatric Research

London, SE5 9RS, United Kingdom
Medizinische Hochschul

Hanover, 30625, Germany
Monroe Carell Jr. Childrens Hospital at Vanderbilt

Nashville, Tennessee, 37232, United States
New York-Presbyterian / Columbia University Irving Medical Center

New York, New York, 10032, United States
Northwell Health System

New Hyde Park, New York, 11042, United States
Oregon Health Science University School of Medicine

Portland, Oregon, 97239, United States
Ospedale Pediatrico Bambino Gesu

Rome, 00165, Italy
Rady Children's Hospital

San Diego, California, 92123, United States
Riley Hospital for Children at IU Health

Indianapolis, Indiana, 46202, United States
Texas Children's Hospital

Houston, Texas, 77030, United States
Texas Liver Institute

San Antonio, Texas, 78215, United States
The Childrens Hospital at Montefiore Albert Einstein School of Medicine

The Bronx, New York, 10467, United States
UCSF

San Francisco, California, 94158, United States
Universitair Medisch Centrum Groningen

Groningen, 9713 GZ, Netherlands
Universitatsklinik fur Kinder-und Jugendmedizin Tubingen

Tübingen, 72076, Germany
University of Malaya Medical Center

Kuala Lumpur, 59100, Malaysia
Wilhelmina Children's Hospital UMCU Utrecht

Utrecht, Netherlands

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