New lupus drug tested for Long-Term safety in large trial

NCT ID NCT04976322

ENROLLING_BY_INVITATION Disease control Sponsor: UCB Biopharma SRL Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Aug 07, 2026 · Updated 3 times

Summary

This study is checking the long-term safety of a drug called dapirolizumab pegol for people with systemic lupus erythematosus (lupus). It involves 760 participants who have already completed earlier studies of the drug. Researchers will monitor side effects over time to see if the drug is safe for extended use.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: dapirolizumab pegol
What this could lead to: If successful, this could confirm that dapirolizumab pegol is safe enough for long-term use in lupus patients, potentially offering a new treatment option to control the disease.
What could go wrong: This is an extension study focused on safety, not on how well the drug works. It may still reveal unexpected side effects, and the drug may not be effective for everyone.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

systemic lupus erythematosus

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

SYSTEMIC LUPUS ERYTHEMATOSUS

Contacts and locations

Locations

Sl0046 20019

Guangzhou, China
Sl0046 20020

Shanghai, China
Sl0046 20025

Wenzhou, China
Sl0046 20030

Chūōku, Japan
Sl0046 20031

Sapporo, Japan
Sl0046 20082

Taiyuan, Taiwan
Sl0046 20095

Taipei, Taiwan
Sl0046 20104

Seoul, South Korea
Sl0046 20108

Incheon, South Korea
Sl0046 20113

Taichung, Taiwan
Sl0046 20128

Beijing, China
Sl0046 20132

Zhengzhou, China
Sl0046 20136

Tianjin, China
Sl0046 20142

Taichung, Taiwan
Sl0046 20171

Sendai, Japan
Sl0046 20180

Wuhan, China
Sl0046 20181

Makati, Philippines
Sl0046 20182

Davao City, Philippines
Sl0046 20204

Suzhou, China
Sl0046 20287

Nagoya, Japan
Sl0046 20290

Guilin, China
Sl0046 20291

Changchun, China
Sl0046 20301

Kurashiki, Japan
Sl0046 40027

Herne, Germany
Sl0046 40031

Szeged, Hungary
Sl0046 40044

Poznan, Poland
Sl0046 40066

Prague, Czechia
Sl0046 40072

Freiburg im Breisgau, Germany
Sl0046 40078

Leipzig, Germany
Sl0046 40084

Catania, Italy
Sl0046 40090

Poznan, Poland
Sl0046 40097

Warsaw, Poland
Sl0046 40098

Warsaw, Poland
Sl0046 40099

Vigo, Spain
Sl0046 40101

Sabadell, Spain
Sl0046 40119

Bydgoszcz, Poland
Sl0046 40123

Brussels, Belgium
Sl0046 40151

Lublin, Poland
Sl0046 40160

Barcelona, Spain
Sl0046 40189

Plovdiv, Bulgaria
Sl0046 40341

Málaga, Spain
Sl0046 40377

Crete, Greece
Sl0046 40378

Athens, Greece
Sl0046 40380

Sofia, Bulgaria
Sl0046 40382

Galati, Romania
Sl0046 40386

Cologne, Germany
Sl0046 40393

Belgrade, Serbia
Sl0046 40397

Wroclaw, Poland
Sl0046 40398

Katowice, Poland
Sl0046 40402

Tübingen, Germany
Sl0046 40411

Debrecen, Hungary
Sl0046 40412

Budapest, Hungary
Sl0046 40448

Milan, Italy
Sl0046 40461

Belgrade, Serbia
Sl0046 40481

Wroclaw, Poland
Sl0046 40482

Bialystok, Poland
Sl0046 40499

Székesfehérvár, Hungary
Sl0046 40501

Athens, Greece
Sl0046 40502

Krakow, Poland
Sl0046 40507

Larissa, Greece
Sl0046 40715

Vogelsang-gommern, Germany
Sl0046 50001

Jackson, Tennessee, 38305, United States
Sl0046 50015

Hagerstown, Maryland, 21740, United States
Sl0046 50045

Toronto, Canada
Sl0046 50050

Beckley, West Virginia, 25801, United States
Sl0046 50052

Phoenix, Arizona, 85032, United States
Sl0046 50058

Avondale, Arizona, 85392, United States
Sl0046 50059

Ormond Beach, Florida, 32174, United States
Sl0046 50140

Birmingham, Alabama, 35294, United States
Sl0046 50147

Hershey, Pennsylvania, 17033, United States
Sl0046 50219

Detroit, Michigan, 48201, United States
Sl0046 50238

Charlotte, North Carolina, 28211, United States
Sl0046 50239

Brandon, Florida, 33511, United States
Sl0046 50240

Idaho Falls, Idaho, 83404, United States
Sl0046 50249

Guadalajara, Mexico
Sl0046 50250

Cuernavaca, Mexico
Sl0046 50251

Monterrey, Mexico
Sl0046 50252

Mérida, Mexico
Sl0046 50259

Rimouski, Canada
Sl0046 50264

Manhasset, New York, 11030, United States
Sl0046 50271

León, Mexico
Sl0046 50273

Las Vegas, Nevada, 89128, United States
Sl0046 50275

La Palma, California, 90623-1730, United States
Sl0046 50285

Lake Charles, Louisiana, 70605, United States
Sl0046 50316

San Leandro, California, 94578, United States
Sl0046 50317

Chihuahua City, Mexico
Sl0046 50324

Plantation, Florida, 33324, United States
Sl0046 50328

Tucson, Arizona, 85704, United States
Sl0046 50329

Tampa, Florida, 33606, United States
Sl0046 50334

New York, New York, 10032, United States
Sl0046 50337

Edmonton AB, Canada
Sl0046 50339

Denver, Colorado, 80230, United States
Sl0046 50362

Gainesville, Florida, 32610, United States
Sl0046 50366

Canton, New York, 13617, United States
Sl0046 50368

Atlanta, Georgia, 30303, United States
Sl0046 50374

Calgary, Canada
Sl0046 50383

Beverly Hills, California, 90210, United States
Sl0046 50418

Colleyville, Texas, 76034, United States
Sl0046 50474

Hopkinsville, Kentucky, 42240-1746, United States
Sl0046 50660

New Orleans, Louisiana, 70112, United States
Sl0046 50662

Glendale, Arizona, 85306, United States
Sl0046 50671

Caguas, Puerto Rico
Sl0046 50681

Miami, Florida, 33172, United States
Sl0046 50698

Tampa, Florida, 33618, United States
Sl0046 60002

Buenos Aires, Argentina
Sl0046 60003

Quilmes, Argentina
Sl0046 60006

Bogotá, Colombia
Sl0046 60007

Chía, Colombia
Sl0046 60009

Lima, Peru
Sl0046 60011

San Juan, Argentina
Sl0046 60013

Barranquilla, Colombia
Sl0046 60014

San Miguel de Tucumán, Argentina
Sl0046 60015

Santiago, Chile
Sl0046 60016

Bucaramanga, Colombia
Sl0046 60018

Santiago, Chile
Sl0046 60019

Barranquilla, Colombia
Sl0046 60022

Quilmes, Argentina
Sl0046 60023

Lima, Peru
Sl0046 60027

Bogotá, Colombia
Sl0046 60029

Mendoza, Argentina
Sl0046 60031

Montería, Colombia

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