Depression drug trial halted: what happened with AXS-05?

NCT ID NCT04634669

First seen Jan 29, 2026 · Last updated May 13, 2026 · Updated 18 times

Summary

This study looked at the long-term safety and effectiveness of an experimental drug called AXS-05 for people with major depression that didn't improve with other treatments. About 181 adults who had already tried other antidepressants without success took part. The study was stopped early, so results are limited.

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Contacts and locations

Locations

  • Clinical Research Site

    Little Rock, Arkansas, 72209, United States

  • Clinical Research Site

    Redlands, California, 92374, United States

  • Clinical Research Site

    Sherman Oaks, California, 91403, United States

  • Clinical Research Site

    Upland, California, 91786, United States

  • Clinical Research Site

    Miami, Florida, 33122, United States

  • Clinical Research Site

    Miami Lakes, Florida, 33016, United States

  • Clinical Research Site

    Orlando, Florida, 32081, United States

  • Clinical Research Site

    Chicago, Illinois, 60634, United States

  • Clinical Research Site

    Boston, Massachusetts, 02131, United States

  • Clinical Research Site

    Berlin, New Jersey, 08009, United States

  • Clinical Research Site

    Rochester, New York, 14618, United States

  • Clinical Research Site

    Staten Island, New York, 10312, United States

  • Clinical Research Site

    Hickory, North Carolina, 28601, United States

  • Clinical Research Site

    Raleigh, North Carolina, 27609, United States

  • Clinical Research Site

    Cincinnati, Ohio, 45215, United States

  • Clinical Research Site

    Middleburg Heights, Ohio, 44130, United States

  • Clinical Research Site

    Media, Pennsylvania, 19063, United States

  • Clinical Research Site

    Dallas, Texas, 75243, United States

  • Clinical Research Site

    Friendswood, Texas, 77546, United States

  • Clinical Research Site

    Everett, Washington, 98201, United States

Conditions

Explore the condition pages connected to this study.