10-Year study to track immune risks of PKU drug
NCT ID NCT06305234
First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This 10-year study will follow 200 people with PKU who are taking or about to start Pegvaliase (Palynziq). Researchers will monitor immune reactions, inflammation, and lab results to better understand long-term safety. The goal is to improve management of side effects like allergic reactions and joint pain.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Pegvaliase (Palynziq)
What this could lead to
If successful, this study could help doctors better manage long-term Pegvaliase treatment for PKU, reducing risks like allergic reactions and joint pain.
What could go wrong
This is an observational study, not a treatment trial. It won't test if Pegvaliase works, only monitors side effects over 10 years. Results may not apply to all patients.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Boston Children's Hospital
RECRUITINGBoston, Massachusetts, 02215, United States
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Children's Wisconsin/Medical College of Wisconsin
RECRUITINGMilwaukee, Wisconsin, 53226, United States
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Emory University
RECRUITINGAtlanta, Georgia, 30322, United States
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Northwestern University
RECRUITINGChicago, Illinois, 60611, United States
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Oregon Health & Science University
RECRUITINGPortland, Oregon, 97239, United States
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Riley Children's Hospital/ Indiana University Health
RECRUITINGIndianapolis, Indiana, 46202, United States
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Tulane University School of Medicine
RECRUITINGNew Orleans, Louisiana, 70112, United States
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UT Southwestern Medical Center
RECRUITINGDallas, Texas, 75390, United States
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University of Colorado
RECRUITINGAurora, Colorado, 80045, United States
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University of Pittsburgh Medical Center
RECRUITINGPittsburgh, Pennsylvania, 15213, United States
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Vanderbilt University Medical School
RECRUITINGNashville, Tennessee, 37235, United States