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Can a Scope-Based procedure offer lasting removal of precancerous gut lesions?

NCT ID NCT07781137

Knowledge-focused Sponsor: Western Sydney Local Health District Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Aug 24, 2026 · Last updated Aug 25, 2026 · Updated 1 time

Summary

This study looks back at 1,000 patients who had endoscopic resection—a minimally invasive procedure to remove abnormal growths—in the duodenum or ampulla over a 15-year period. The goal is to see how often the lesions come back, how often cancer develops, and what complications occur. By analyzing these long-term outcomes, researchers hope to identify which patients benefit most and how best to monitor them after the procedure.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Endoscopic resection (a minimally invasive procedure to remove lesions from the duodenum and ampulla)
What this could lead to
If successful, this research could help doctors better predict which patients benefit most from endoscopic resection and improve follow-up care to catch recurrences early.
What could go wrong
Because this is a retrospective review of past cases, it cannot prove cause and effect. Results may be limited by incomplete records or changes in techniques over the 15-year period.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

About 1,000 people

The number the study aims to enrol. It can still change while the study runs.

Started

May 2025

Expected to finish

Jan 2030

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

This study will be conducted at a tertiary referral centre specialising in endoscopic therapy in the duodenum and ampulla. Identifying patients: Participants will be sourced through the current electronic documentation system, utilising the following methods: Provation (endoscopic reporting software) key search for key terms related to: * Duodenal polyp(s) * Duodenal lesion * Duodenal SEL * Duodenal submucosal lesion * Duodenal EMR * Duodenal ESD * Papillectomy * Ampullectomy Electronic referral pathway for endoscopic retrograde cholangiopancreatogram (ERCP) at Westmead Hospital for indications showing: * Duodenal polyp(s) * Duodenal lesion * Duodenal EMR * Duodenal ESD * Papillectomy * Ampullectomy

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Age greater than 18 * Mucosal or submucosal lesion in the duodenum or ampulla with endoscopic resection performed at Westmead hospital Endoscopic resection occurred between January 2010 to March 2025 Exclusion Criteria: * Age less than 18

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Conditions

The condition(s) this trial relates to.

adenoma carcinoma of duodenum duodenum cancer papillary adenocarcinoma papillary adenoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Duodenal adenoma Duodenal carcinoma Endoscopic mucosal resection Papillary adenocarcinoma Papillary adenoma

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Westmead Endoscopy, Westmead hospital, Western Sydney Local Health District

    RECRUITING

    Sydney, New South Wales, Australia

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