CAR-T therapy for multiple myeloma: what happens years later?

NCT ID NCT05201781

Recruiting now Disease control Sponsor: Janssen Research & Development, LLC Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jul 07, 2026 · Updated 3 times

Summary

This study follows 295 multiple myeloma patients who previously received cilta-cel (a CAR-T cell therapy) to track long-term side effects. No new treatment is given. Researchers will monitor for new cancers, nerve disorders, autoimmune issues, and infections over time. The goal is to better understand the lasting safety of this therapy.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: cilta-cel (CAR-T cell therapy)
What this could lead to: If successful, this study will help doctors understand the long-term safety of cilta-cel, potentially improving monitoring and care for multiple myeloma patients.
What could go wrong: This is an observational follow-up study, not a new treatment trial. It cannot show whether cilta-cel works better than other options, and results may not apply to all patients.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

plasma cell myeloma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

MULTIPLE MYELOMA

Contacts and locations

Locations

Barbara Ann Karmanos Cancer Institute
RECRUITING

Detroit, Michigan, 48201, United States
Beth Israel Deaconess Medical Center
RECRUITING

Boston, Massachusetts, 02215, United States
CHRU de Lille Hopital Claude Huriez
RECRUITING

Nord, 59037, France
City of Hope
RECRUITING

Duarte, California, 91010, United States
Clinica Univ. de Navarra
RECRUITING

Pamplona, 31008, Spain
Dana Farber Cancer Institute
RECRUITING

Boston, Massachusetts, 02115, United States
Emory University
RECRUITING

Atlanta, Georgia, 30322, United States
First Hospital, Zhejiang University Medical College
ACTIVE_NOT_RECRUITING

Hangzhou, 310003, China
Froedtert Memorial
RECRUITING

Milwaukee, Wisconsin, 53226, United States
Fujian Medical University Union Hospital
ACTIVE_NOT_RECRUITING

Fuzhou, 350000, China
Hackensack University Medical Center
RECRUITING

Hackensack, New Jersey, 07601, United States
Hopital Saint Louis
RECRUITING

Paris, 75010, France
Hosp Clinico Univ de Salamanca
RECRUITING

Salamanca, 37007, Spain
Indiana University
RECRUITING

Indianapolis, Indiana, 46202, United States
Japanese Red Cross Medical Center
ACTIVE_NOT_RECRUITING

Shibuya City, 150-8935, Japan
Jiangsu Province Hospital
ACTIVE_NOT_RECRUITING

Nanjing, 210029, China
Kansas University Medical Center
RECRUITING

Westwood, Kansas, 66205, United States
Levine Cancer Institute
RECRUITING

Charlotte, North Carolina, 28204, United States
MD Anderson Cancer Center
RECRUITING

Houston, Texas, 77030, United States
Massachusetts General Hospital
RECRUITING

Boston, Massachusetts, 02215, United States
Mayo Clinic Cancer Center-Scottsdale
RECRUITING

Phoenix, Arizona, 85054, United States
Mayo Clinic Rochester
RECRUITING

Rochester, Minnesota, 55902, United States
Memorial Sloan Kettering Cancer Center
RECRUITING

New York, New York, 10065, United States
Moffitt Cancer Center
RECRUITING

Tampa, Florida, 33612, United States
Montefiore Medical Center
RECRUITING

The Bronx, New York, 10467, United States
Mount Sinai Medical Center
RECRUITING

New York, New York, 10029, United States
Nagoya City University Hospital
ACTIVE_NOT_RECRUITING

Nagoya, 467 8602, Japan
Nanjing Drum Tower Hospital The Affiliated Hospital of Nanjing University Medical School
ACTIVE_NOT_RECRUITING

Nanjing, 210008, China
Northwestern University
RECRUITING

Chicago, Illinois, 60611, United States
Peking University Third Hospital
ACTIVE_NOT_RECRUITING

Beijing, 100191, China
Roswell Park Cancer Institute
RECRUITING

Buffalo, New York, 14263, United States
Ruijin Hospital Shanghai Jiao Tong University
ACTIVE_NOT_RECRUITING

Shanghai, 200025, China
Rutgers Cancer Institute of New Jersey
RECRUITING

New Brunswick, New Jersey, 08903, United States
Sarah Cannon Research Institute
RECRUITING

Nashville, Tennessee, 37203, United States
Shanghai Changzheng Hospital
ACTIVE_NOT_RECRUITING

Shanghai, 200003, China
Shanghai Fourth People s Hospital
ACTIVE_NOT_RECRUITING

Shanghai, 200434, China
Stanford University Medical Center
RECRUITING

Stanford, California, 94305-5623, United States
Sun Yat-sen University Cancer Hospital
ACTIVE_NOT_RECRUITING

Guangzhou, 510060, China
Tel Aviv Sourasky Medical Center
RECRUITING

Tel Aviv, 64239, Israel
The Second Affiliated Hospital of Xi'an Jiaotong University
ACTIVE_NOT_RECRUITING

Xi'an, 710004, China
UZ Gent
RECRUITING

Ghent, 9000, Belgium
UZ Leuven
RECRUITING

Leuven, 3000, Belgium
University Medical Center Groningen
RECRUITING

Groningen, 9713 GZ, Netherlands
University of California San Francisco
RECRUITING

San Francisco, California, 94143, United States
University of Chicago
RECRUITING

Chicago, Illinois, 60637, United States
University of Pennsylvania
RECRUITING

Philadelphia, Pennsylvania, 19104, United States
University of Pittsburgh Medical Center
RECRUITING

Pittsburgh, Pennsylvania, 15232, United States
VU Medisch Centrum
RECRUITING

Amsterdam, 1081 HV, Netherlands
Washington University School Of Medicine
RECRUITING

St Louis, Missouri, 63110, United States
West China Hospital Si Chuan University
ACTIVE_NOT_RECRUITING

Chengdu, 610041, China

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