Major trial tests new drug to prevent dangerous COPD Flare-Ups

NCT ID NCT05742802

Ongoing Disease control Sponsor: AstraZeneca Source: ClinicalTrials.gov ↗

Summary

This study is testing the long-term safety and effectiveness of an investigational drug called tozorakimab for people with chronic obstructive pulmonary disease (COPD). It is for adults with COPD who have a history of symptom flare-ups and previously completed one of two related studies. The main goal is to see if the drug can reduce the rate of severe flare-ups over time compared to a placebo.

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Contacts and locations

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Locations

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Sheffield, Alabama, 35660, United States
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Tempe, Arizona, 85283, United States
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Lincoln, California, 95648, United States
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Newport Beach, California, 92663, United States
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Northridge, California, 91324, United States
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Boynton Beach, Florida, 33435, United States
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Cape Coral, Florida, 33990, United States
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Ormond Beach, Florida, 32174, United States
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Pensacola, Florida, 32503, United States
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Plantation, Florida, 33324, United States
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Tampa, Florida, 33607, United States
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Winter Park, Florida, 32789, United States
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Evergreen Park, Illinois, 60805, United States
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Normal, Illinois, 61761, United States
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Greenwood, Indiana, 46143, United States
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Kansas City, Kansas, 66160, United States
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Bowling Green, Kentucky, 42101, United States
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Baton Rouge, Louisiana, 70836, United States
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Zachary, Louisiana, 70791, United States
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Baltimore, Maryland, 21224, United States
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White Marsh, Maryland, 21162, United States
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North Dartmouth, Massachusetts, 02747, United States
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Farmington Hills, Michigan, 48336, United States
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Grand Rapids, Michigan, 49546, United States
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Rochester, Minnesota, 55905, United States
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St Louis, Missouri, 63110, United States
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Buffalo, New York, 14203, United States
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Durham, North Carolina, 27705, United States
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Gastonia, North Carolina, 28054, United States
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Fargo, North Dakota, 58104, United States
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Toledo, Ohio, 43617, United States
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Tulsa, Oklahoma, 74133, United States
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DuBois, Pennsylvania, 15801, United States
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Philadelphia, Pennsylvania, 19140, United States
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Pittsburgh, Pennsylvania, 15213, United States
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Sayre, Pennsylvania, 18840, United States
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Rock Hill, South Carolina, 29732, United States
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Franklin, Tennessee, 37067, United States
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Amarillo, Texas, 79106, United States
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Boerne, Texas, 78006, United States
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Kingwood, Texas, 77339, United States
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McKinney, Texas, 75069, United States
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Tomball, Texas, 77375, United States
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Colchester, Vermont, 05446, United States
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Williamsburg, Virginia, 23188, United States
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Cudahy, Wisconsin, 53110, United States
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Buenos Aires, C1121 ABE, Argentina
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CABA, C1425BEN, Argentina
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Ciudad de Buenos Aires, C1414AIF, Argentina
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Córdoba, X5003DCE, Argentina
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Mar del Plata, 7600, Argentina
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Mar del Plata, B7600GWV, Argentina
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Mendoza, M5500CCG, Argentina
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Quilmes, B1878FNR, Argentina
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San Fernando, B1646EBJ, Argentina
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San Juan Bautista, 1888, Argentina
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San Miguel de Tucumán, T4000IAR, Argentina
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Campbelltown, 2560, Australia
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Frankstown, 3199, Australia
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Macquarie University, 2109, Australia
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Melbourne, 3000, Australia
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Nedlands, 6009, Australia
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Southport, 4215, Australia
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Spearwood, 6163, Australia
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Wollongong, 2500, Australia
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Woodville South, 5011, Australia
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Brussels, 1000, Belgium
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Ghent, 9000, Belgium
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Leuven, 3000, Belgium
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Liège, 4000, Belgium
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Namur, 5101, Belgium
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Blumenau, 89030-101, Brazil
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Botucatu, 18618-686, Brazil
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Brasília, 71681-603, Brazil
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Curitiba, 80440-220, Brazil
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Porto Alegre, 90035074, Brazil
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Porto Alegre, 9061-000, Brazil
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Porto Alegre, 91010-006, Brazil
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Rio de Janeiro, 22061-080, Brazil
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São Bernardo do Campo, 09750-420, Brazil
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São Paulo, 01409-001, Brazil
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São Paulo, 05403-000, Brazil
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Dupnitsa, 2600, Bulgaria
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Kozloduy, 3320, Bulgaria
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Lovech, 5500, Bulgaria
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Petrich, 2850, Bulgaria
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Pleven, 5800, Bulgaria
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Rousse, 7002, Bulgaria
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Sliven, 8800, Bulgaria
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Sofia, 1000, Bulgaria
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Sofia, 1606, Bulgaria
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Vratsa, 3000, Bulgaria
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Edmonton, Alberta, T5A 4L8, Canada
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Sherwood Park, Alberta, T8L 0N2, Canada
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Ajax, Ontario, L1S 2J5, Canada
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Guelph, Ontario, N1H 6J2, Canada
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Winchester, Ontario, K0C 2K0, Canada
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Montreal, Quebec, H3T 1E2, Canada
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Québec, Quebec, G1G 5X1, Canada
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Québec, Quebec, G1V 4G5, Canada
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Chile, 7770484, Chile
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Curicó, 3341643, Chile
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Santiago, 7500010, Chile
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Santiago, 7500698, Chile
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Santiago, 8150000, Chile
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Talca, 3465584, Chile
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Baotou, 14010, China
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Beijing, 100057, China
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Beijing, 100144, China
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Changchun, 130021, China
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Changsha, 410015, China
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Chengdu, 610000, China
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Chengdu, 610014, China
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Chongqing, 400013, China
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Chongqing, 400037, China
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Guangzhou, 510120, China
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Guangzhou, 510180, China
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Haikou, 570311, China
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Hangzhou, 310006, China
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Hohhot, 010010, China
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Kunming, 650032, China
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Linhai, 317000, China
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Nanchang, 330006, China
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Nanjing, 210006, China
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Ningbo, 315010, China
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Shanghai, 200002, China
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Shanghai, 201199, China
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Shenyang, 110000, China
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Shenyang, 110004, China
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Shenzhen, 518020, China
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Shenzhen, 518053, China
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Shijiazhuang, 50051, China
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Suzhou, 215002, China
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Taiyuan, 030001, China
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Wuhan, 430022, China
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Wuxi, 214023, China
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Xiamen, 361004, China
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Xuzhou, 221000, China
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Xuzhou, 221009, China
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Yangzhou, 225001, China
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Yinchuan, 750004, China
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Zhanjiang, 524004, China
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Zunyi, 563100, China
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Barranquilla, 80007, Colombia
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Ibagué, 730006, Colombia
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Rionegro, 054047, Colombia
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Zipaquirá, 200251, Colombia
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Brno, 625 00, Czechia
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Jindřichův Hradec, 377 01, Czechia
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Liberec, 460 63, Czechia
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Olomouc, 779 00, Czechia
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Rokycany, 337 01, Czechia
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Aalborg, 9000, Denmark
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Copenhagen, 2400, Denmark
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Hvidovre, 2650, Denmark
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Næstved, 4700, Denmark
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Roskilde, 4000, Denmark
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Vejle, 7100, Denmark
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Hämeenlinna, 13530, Finland
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Helsinki, 00290, Finland
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Kuopio, 70210, Finland
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Turku, 20520, Finland
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Bordeaux, 33076, France
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Brest, 29609, France
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La Tronche, 38700, France
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Lyon, 69317, France
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Marseille, 13326, France
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Montpellier, 34295, France
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Nantes, 44093, France
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Toulouse, 31300, France
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Ahrensburg, 22926, Germany
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Bamberg, 96049, Germany
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Berlin, 10717, Germany
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Berlin, 12157, Germany
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Cologne, 51069, Germany
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Darmstadt, 64283, Germany
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Halle, 06108, Germany
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Marburg, 35037, Germany
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Peine, 31224, Germany
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Alexandroupoli, 68100, Greece
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Athens, 11527, Greece
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Exohi Thessaloniki, 57010, Greece
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Ioannina, 45500, Greece
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Pátrai, 26500, Greece
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Thessaloniki, 57010, Greece
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Budapest, 1036, Hungary
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Debrecen, 4032, Hungary
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Edelény, 3780, Hungary
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Encs, 3860, Hungary
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Mosonmagyaróvár, 9200, Hungary
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Nyíregyháza-Sóstóhegy, 4481, Hungary
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Százhalombatta, 2440, Hungary
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Belagavi, 590010, India
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Coimbatore, 641028, India
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Dehradun, 248001, India
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Jaipur, 302039, India
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Nagpur, 440012, India
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Nashik, 422007, India
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New Delhi, 110029, India
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Thane, 401107, India
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Ashkelon, 78278, Israel
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Beersheba, 8410101, Israel
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Jerusalem, 9103102, Israel
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Kfar Saba, 4428164, Israel
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Rehovot, 76100, Israel
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Tel Aviv, 6423906, Israel
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Bari, 70124, Italy
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Carrara, 54033, Italy
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Milan, 20142, Italy
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Milan, 20157, Italy
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Naples, 80131, Italy
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Roma, 00168, Italy
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Salerno, 84131, Italy
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Sassari, 07100, Italy
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Statte, 74010, Italy
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Telese Terme, 82037, Italy
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Tradate, 21049, Italy
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Vercelli, 13100, Italy
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Verona, 37124, Italy
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Asahikawa-shi, 078-8510, Japan
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Fujieda-shi, 426-8677, Japan
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Fukuoka, 819-8555, Japan
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Hamamatsu, 430-8525, Japan
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Hiroshima, 734-8530, Japan
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Iizuka-shi, 820-8505, Japan
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Itabashi-ku, 173-8610, Japan
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Iwata-shi, 438-8550, Japan
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Kanazawa, 920-8650, Japan
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Kawachinagano-shi, 586-8521, Japan
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Kobe, 651-0072, Japan
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Matsusaka-shi, 515-8544, Japan
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Mizunami-shi, 509-6134, Japan
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Nagoya, 460-0001, Japan
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Obihiro, 080-0017, Japan
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Okayama, 700-8558, Japan
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Osaka, 531-0073, Japan
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Osaka, 543-8555, Japan
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Osaka, 545-8586, Japan
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Shinjuku-ku, 162-8655, Japan
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Shizuoka, 420-8630, Japan
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Toshima-ku, 170-0003, Japan
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Toyonaka-shi, 560-8552, Japan
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Yokohama, 221-0855, Japan
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Yokohama, 223-0059, Japan
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Yokohama, 232-0024, Japan
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Benito Juárez, 03650, Mexico
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Chihuahua City, 31000, Mexico
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Guadalajara, 44100, Mexico
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Guadalajara, 44200, Mexico
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México, 01710, Mexico
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Monterrey, 64460, Mexico
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Morelia, 58000, Mexico
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Oaxaca City, 68020, Mexico
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Veracruz, 91910, Mexico
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Eindhoven, 5623EJ, Netherlands
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Groningen, 9713 GZ, Netherlands
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Harderwijk, 3844 DG, Netherlands
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Heerlen, 6419 PC, Netherlands
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Zutphen, 7207 AE, Netherlands
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Lørenskog, 1478, Norway
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Oslo, 450, Norway
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Tønsberg, 3103, Norway
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Lima, 15036, Peru
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Lima, 15046, Peru
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Lima, 15088, Peru
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Lima, LIMA 21, Peru
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Baguio City, 2600, Philippines
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Cebu City, 6000, Philippines
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Iloilo City, 5000, Philippines
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Bialystok, 15-044, Poland
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Bydgoszcz, 85-796, Poland
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Katowice, 40-648, Poland
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Krakow, 30-033, Poland
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Lublin, 20-412, Poland
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Ostrowiec Świętokrzyski, 27-400, Poland
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Ostróda, 14-100, Poland
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Poznan, 60-693, Poland
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Rzeszów, 35-205, Poland
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Sosnowiec, 41-208, Poland
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Wroclaw, 53-301, Poland
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Guimarães, 4835-235, Portugal
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Lisbon, 1649-035, Portugal
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Lisbon, 1998-018, Portugal
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Matosinhos Municipality, 4454-509, Portugal
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Vila Franca de Xira, 2600-009, Portugal
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Brasov, 500283, Romania
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Bucharest, 050159, Romania
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Cluj-Napoca, 400371, Romania
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Timișoara, 300002, Romania
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Daegu, 42415, South Korea
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Incheon, 21431, South Korea
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Jeonju, 54907, South Korea
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Seoul, 05030, South Korea
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Seoul, 06591, South Korea
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Seoul, 07061, South Korea
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Galdakao, 48960, Spain
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Madrid, 28040, Spain
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Málaga, 29010, Spain
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Mérida, 06800, Spain
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Pozuelo de Alarcón, 28223, Spain
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Santander, 39008, Spain
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Valencia, 46010, Spain
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Zaragoza, 50009, Spain
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Gothenburg, 413 46, Sweden
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Gothenburg, 41345, Sweden
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Lund, 222 22, Sweden
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Stockholm, 11239, Sweden
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Hsinchu, 300, Taiwan
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Kaohsiung City, 80756, Taiwan
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Taichung, 40447, Taiwan
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Taichung, 40705, Taiwan
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Taipei, 10002, Taiwan
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Taipei, 110, Taiwan
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Taoyuan District, 333, Taiwan
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Yunlin, 640, Taiwan
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Bang Kra So, 11000, Thailand
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Hat Yai, 90110, Thailand
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Khon Kaen, 40002, Thailand
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Muang,, 55000, Thailand
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Muang, 22000, Thailand
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Mueang, 20000, Thailand
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Nakhon Ratchasima, 30000, Thailand
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Ankara, 06620, Turkey (Türkiye)
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Istanbul, 34854, Turkey (Türkiye)
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Mersin, 33343, Turkey (Türkiye)
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Bradford, BD9 6RJ, United Kingdom
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Corby, NN17 2UR, United Kingdom
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Corby, NN18 9EZ, United Kingdom
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High Wycombe, HP11 2QW, United Kingdom
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Northwood, HA6 2RN, United Kingdom
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Preston, PR2 9QB, United Kingdom
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Shipley, BD18 3SA, United Kingdom
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Hanoi, 100000, Vietnam
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Hanoi, 10000, Vietnam
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Ho Chi Minh City, 700000, Vietnam

Conditions

Explore the condition pages connected to this study.

CHRONIC OBSTRUCTIVE PULMONARY DISEASE (COPD)