New drug aims to keep rare nerve disease in check long-term
NCT ID NCT05405361
First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study is a long-term follow-up for people with multifocal motor neuropathy, a rare condition that causes muscle weakness. It tests the safety and effectiveness of a drug called ARGX-117, given intravenously. The trial includes 51 adults who previously took part in an earlier study, and it involves both double-blinded and open-label treatment periods.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- ARGX-117
- What this could lead to
- If it works, this could provide a long-term treatment option to control muscle weakness in people with multifocal motor neuropathy.
- What could go wrong
- This is a small, early-phase extension study with only 51 participants, so results may not apply to everyone. Long-term safety and effectiveness are still uncertain.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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AZ Sint-Lucas
Ghent, 9000, Belgium
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Austin Neuromuscular Center
Austin, Texas, 78759, United States
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Azienda Ospedaliera Sant' Andrea
Rome, 00189, Italy
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Azienda Ospedaliero Universitaria Pisana
Pisa, 56126, Italy
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CHU Bordeaux - Groupe Hospitalier Pellegrin
Bordeaux, 33076, France
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CHU de Nice
Nice, 06001, France
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HonorHealth Neurology
Scottsdale, Arizona, 85251, United States
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Hospital Universitari i Politecnic La Fe de Valencia
Valencia, 46026, Spain
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Hospital Universitario Vall d'Hebron
Barcelona, 08035, Spain
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Hospital de La Santa Creu i Sant Pau
Barcelona, 08041, Spain
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Hôpital Roger Salengro (CHU de Lille)
Lille, 59037, France
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Hôpital de la Pitié Salpétrière
Paris, 75651, France
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IRCCS Humanitas Research Hospital
Rozzano, 20089, Italy
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IRCCS Ospedale San Raffaele S.r.l.
Milan, 20132, Italy
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Medizinische Universitat Wien (Medical University of Vienna)
Vienna, 1090, Austria
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Michalski i Partnerzy Lekarze Spolka Partnerska
Krakow, 31-426, Poland
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NorthShore University HealthSystem
Glenview, Illinois, 60026, United States
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Oxford University Hospitals NHS Trust
Oxford, OX3 9DU, United Kingdom
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Queen Elizabeth University Hospital
Glasgow, G51 4TF, United Kingdom
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The Cleveland Clinic Foundation
Cleveland, Ohio, 44195, United States
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Universitair Medisch Centrum Utrecht
Utrecht, 3584 CX, Netherlands
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Universitatsmedizin Gottingen (UMG) Georg-August-Universitaet
Göttingen, 37075, Germany
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University Health Network
Toronto, Canada
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University of Minnesota
Minneapolis, Minnesota, 55414, United States
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University of Pennsylvania - Perelman Center for Advanced Medicine
Philadelphia, Pennsylvania, 19104, United States
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Universitätsklinikum Essen
Essen, 45147, Germany
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Warszawski Uniwersytet Medyczny
Warsaw, 02-097, Poland
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