Liquid vs crushed pills: which works better for babies with low thyroid?

NCT ID NCT05228184

Terminated Disease control Sponsor: IBSA Institut Biochimique SA Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study compared a liquid form of thyroid medication (Tirosint-SOL) to crushed tablets in 34 infants with congenital hypothyroidism. The goal was to see which form helps maintain normal thyroid hormone levels more easily. However, the study was stopped early, so firm conclusions cannot be drawn.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: levothyroxine (thyroid hormone)
What this could lead to: If successful, this could show that a liquid form of thyroid medication is easier to dose accurately in infants than crushed tablets.
What could go wrong: The trial was terminated early with only 34 out of 126 planned participants, so results may be incomplete and not reliable.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Get updates

Get notified about this study

Sign up to get updates when this study changes or when new studies for CONGENITAL HYPOTHYROIDISM are added.

Our safety recommendation!

By submitting, you agree to our Terms of use

Conditions

The condition(s) this trial relates to.

congenital hypothyroidism

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CONGENITAL HYPOTHYROIDISM

Contacts and locations

Locations

Ann & Robert H. Lurie Children's Hospital of Chicago

Chicago, Illinois, 60611, United States
Boston Children's Hospital

Boston, Massachusetts, 02115, United States
CHOC Children's Hospital

Orange, California, 92868, United States
Children's Hospital Medical Center

Cincinnati, Ohio, 45229, United States
Children's Hospital of Atlanta

Atlanta, Georgia, 30329, United States
Children's Hospital of Los Angeles

Los Angeles, California, 90027, United States
Children's Mercy Hospital and Clinics

Kansas City, Missouri, 64111, United States
Cook Children's Health Care Systems

Fort Worth, Texas, 76104, United States
University of California San Francisco

San Francisco, California, 94143, United States
Yale University

New Haven, Connecticut, 06511, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.