Could a prostate cancer drug help fight lung cancer?
NCT ID NCT06512207
First seen Jun 26, 2026 · Last updated Jun 26, 2026
Summary
This study tests whether adding a hormone therapy (leuprorelin) to an immunotherapy (sintilimab) can help older men with advanced lung cancer. The idea is that lowering sex hormones may rejuvenate the immune system, making the immunotherapy more effective. Eighty men aged 60 and older with stage III or IV non-small cell lung cancer will receive both drugs, and researchers will track tumor shrinkage and immune cell changes.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- leuprorelin acetate (hormone therapy) and sintilimab (immunotherapy)
- What this could lead to
- If it works, this combination could offer a new treatment option for advanced lung cancer in older men, potentially improving tumor shrinkage and disease control.
- What could go wrong
- This is an early-stage trial with only 80 participants, all older men, so results may not apply to others. The combination may cause side effects like fatigue, hormone-related issues, or immune reactions, and may not improve outcomes.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
The Third Oncology Ward, First Affiliated Hospital of Zhengzhou University
RECRUITINGZhengzhou, Henan, 450052, China
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