Endometriosis pain relief: letrozole takes on danazol in new study

NCT ID NCT07183787

Completed Symptom relief Sponsor: Sidra Salman Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 26, 2026

Summary

This study tested two drugs, letrozole and danazol, to see which better reduces pelvic pain in women with endometriosis. Sixty women aged 18-45 with moderate to severe pain took one of the two drugs daily for 12 weeks. The main goal was to measure changes in pain scores, with the hope of finding a more effective or better-tolerated treatment option.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Letrozole (2.5 mg daily) and danazol (200 mg twice daily), both taken orally for 12 weeks.
What this could lead to: If letrozole works as well as or better than danazol, it could offer a new, possibly better-tolerated option for managing endometriosis pain.
What could go wrong: This is a small, phase 2 study with only 60 participants, so results may not apply to everyone. Both drugs have side effects, and the study doesn't show long-term safety or effectiveness.

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Conditions

The condition(s) this trial relates to.

endometriosis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ENDOMETRIOSIS

Contacts and locations

Locations

Sharif Medical and Dental College

Lahore, Punjab Province, 54700, Pakistan

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