Can a hormone blocker make miscarriage care more complete?

NCT ID NCT06452719

Completed Disease control Sponsor: University of Pennsylvania Source: ClinicalTrials.gov ↗

First seen Aug 10, 2026 · Last updated Aug 11, 2026 · Updated 1 time

Summary

This pilot study explores whether taking letrozole for three days before using misoprostol can improve the medical management of early pregnancy loss. The goal is to see if this combination more completely empties the uterus, potentially reducing the need for additional procedures. Adults with a confirmed first-trimester loss will receive the treatment and be followed for effectiveness, side effects, and how acceptable they find it.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: letrozole followed by misoprostol
What this could lead to: If effective, this combination could offer a more complete, less invasive option for managing early pregnancy loss, potentially reducing the need for surgical procedures.
What could go wrong: This is a small pilot study, so results may not be definitive or generalizable. Side effects and the need for additional interventions remain possible.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Abortion, Spontaneous

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

EARLY PREGNANCY LOSS MISCARRIAGE MISCARRIAGE IN FIRST TRIMESTER

Contacts and locations

Locations

PEACE / Penn Medicine

Philadelphia, Pennsylvania, 19104, United States

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