Promising new combo therapy for rare plasma cell tumors shows early potential

NCT ID NCT04174196

First seen Dec 15, 2025 · Last updated May 13, 2026 · Updated 14 times

Summary

This study tests whether combining two drugs (lenalidomide and CC-486) with radiation therapy is safe and effective for people with plasmacytoma, a type of plasma cell tumor that can be linked to multiple myeloma. About 21 participants will receive the treatment to see if it leads to a complete response, meaning no signs of cancer after six cycles. The goal is to find a better way to control the disease and prevent it from coming back.

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Contacts and locations

Locations

  • Memorial Sloan Kettering Basking Ridge

    Basking Ridge, New Jersey, 07920, United States

  • Memorial Sloan Kettering Bergen

    Montvale, New Jersey, 07645, United States

  • Memorial Sloan Kettering Cancer Center

    New York, New York, 10065, United States

  • Memorial Sloan Kettering Cancer Center @ Commack

    Commack, New York, 11725, United States

  • Memorial Sloan Kettering Monmouth

    Middletown, New Jersey, 07748, United States

  • Memorial Sloan Kettering Nassau

    Uniondale, New York, 11553, United States

  • Memorial Sloan Kettering Westchester

    Harrison, New York, 10604, United States

Conditions

Explore the condition pages connected to this study.