Laughing gas shows promise for depression in tiny brain scan study

NCT ID NCT05528718

First seen Mar 30, 2026 · Last updated May 11, 2026 · Updated 8 times

Summary

This small pilot study tested whether laughing gas (nitrous oxide) can improve mood in people with major depression. 11 participants received either laughing gas or a comparison drug, and had brain scans to look for changes in brain activity. The goal was to see if laughing gas could be a new treatment option for depression.

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Contacts and locations

Locations

  • St. Michael's Hospital

    Toronto, Ontario, M5B 1M8, Canada

Conditions

Explore the condition pages connected to this study.