New laser combo eases locked jaws in rare skin disease

NCT ID NCT05995626

First seen Apr 20, 2026 · Last updated May 15, 2026 · Updated 3 times

Summary

This small early study tested a new way to treat microstomia (mouth tightening) caused by scleroderma. Three adults received three sessions of a laser followed by hyaluronidase enzyme application to loosen the skin around the mouth. The goal was to increase mouth opening for easier eating, speaking, and oral care. The study is complete, but results are not yet reported.

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Contacts and locations

Locations

  • Nebraska Medicine, Dermatology Westroads

    Omaha, Nebraska, 68114, United States

  • University of Nebraska Medical Center, Lauritzen Outpatient Center

    Omaha, Nebraska, 68105, United States

Conditions

Explore the condition pages connected to this study.