Could CAR-T cells tame tough lupus kidney disease?
NCT ID NCT05938725
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This early-phase trial is testing a new treatment called KYV-101, which uses a patient's own modified immune cells (CAR-T cells) to target and destroy faulty B cells that drive lupus kidney inflammation. The study involves 6 adults with lupus nephritis that hasn't responded to standard therapies. Researchers are primarily checking for safety and side effects, while also looking for signs that the treatment can improve kidney function.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- KYV-101 anti-CD19 CAR-T cell therapy
- What this could lead to
- If successful, this could point toward a new treatment option for people with hard-to-treat lupus kidney disease, potentially reducing the need for long-term immunosuppression.
- What could go wrong
- This is a very early, small trial with only 6 participants, so results may not apply widely. CAR-T therapy carries risks like severe immune reactions and infections.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Northwell Health
Great Neck, New York, 11021, United States
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Ohio State University Wexner Medical Center
Columbus, Ohio, 43210, United States
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Stanford University Medical Center
Palo Alto, California, 94305, United States
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University of Colorado
Denver, Colorado, 80045, United States
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University of Massachusetts Worcester
Worcester, Massachusetts, 01655, United States
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University of Pennsylvania
Philadelphia, Pennsylvania, 19104, United States
More trials for these conditions
Other studies related to the condition(s) this trial covers.
- A simple blood test may reveal kidney damage in lupus — no biopsy needed?
- Can a Three-Drug combo quiet lupus kidney flares?
- Can a single infusion tame tough lupus?
- Can a smartphone app bridge the lupus care gap for women of color?
- Can a single drug calm lupus kidney disease without a cocktail of meds?
- Cancer drug shows promise for lupus kidney disease