New painkiller may cut opioid use after knee surgery
NCT ID NCT07216586
First seen Nov 01, 2025 · Last updated May 06, 2026 · Updated 23 times
Summary
This study compares two methods to control pain after total knee replacement: a new long-acting painkiller (Zynrelef) injected into the knee during surgery versus a standard nerve block. Researchers will measure how much opioid pain medication patients need in the first 72 hours after surgery. The goal is to find which approach provides better pain relief and reduces the need for strong opioids. 120 adults having knee replacement will take part.
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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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University of Miami
Miami, Florida, 33125, United States
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