New study finds better ways to manage knee pain without opioids

NCT ID NCT04504812

First seen Apr 19, 2026 · Last updated May 01, 2026 · Updated 4 times

Summary

This study tested different non-surgical treatments to reduce pain and improve daily function in 1,937 adults with knee osteoarthritis. The goal was to find which treatments work best so people can avoid relying on opioids. Results help doctors choose the right treatment for each patient.

Disclaimer Read more

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

Get updates

Get notified about this study

Sign up to get updates when this study changes or when new studies for KNEE OSTEOARTHRITIS are added.

Our safety recommendation!

By submitting, you agree to our Terms of use

Contacts and locations

Locations

  • Atlanta VA Medical Center

    Decatur, Georgia, 30033, United States

  • Brigham and Women's Hospital

    Boston, Massachusetts, 02199, United States

  • Cleveland VA Medical Center

    Cleveland, Ohio, 44106, United States

  • Emory University

    Atlanta, Georgia, 30322, United States

  • Johns Hopkins

    Baltimore, Maryland, 21287, United States

  • Northwestern University

    Chicago, Illinois, 60611, United States

  • Oregon Health and Science University

    Portland, Oregon, 97239, United States

  • University Hospitals

    Cleveland, Ohio, 44106, United States

  • University of California Davis

    Sacramento, California, 95817, United States

  • University of California San Diego

    San Diego, California, 92037, United States

  • University of Colorado

    Aurora, Colorado, 80045, United States

  • University of Florida

    Gainesville, Florida, 32608, United States

  • University of Iowa

    Iowa City, Iowa, 52242, United States

  • University of Minnesota

    Minneapolis, Minnesota, 55455, United States

  • University of North Carolina

    Chapel Hill, North Carolina, 27599, United States

  • University of Rochester Medical Center

    Rochester, New York, 14623, United States

  • University of Utah

    Salt Lake City, Utah, 84108, United States

  • University of Virginia

    Charlottesville, Virginia, 22908, United States

  • University of Washington

    Seattle, Washington, 98185, United States

  • VA Medical Center San Diego

    San Diego, California, 92161, United States

  • Vanderbilt University

    Nashville, Tennessee, 37232, United States

  • Wake Forest University

    Winston-Salem, North Carolina, 27517, United States

  • Walter Reed Army Medical Center

    Bethesda, Maryland, 20889, United States

  • Weill Cornell University

    New York, New York, 10019, United States

Conditions

Explore the condition pages connected to this study.