Could a stem cell transplant free kidney recipients from a lifetime of anti-rejection drugs?
NCT ID NCT03591302
First seen Jul 01, 2026 · Last updated Jul 02, 2026 · Updated 1 time
Summary
This study tests whether a stem cell transplant from the same donor can help people with a functioning kidney transplant stop taking immunosuppressive drugs. Participants receive total lymphoid irradiation and anti-thymocyte globulin to prepare their immune system, followed by an infusion of donor stem cells and T-cells. The goal is to see if the body can accept the kidney without long-term medication. The trial includes adults who have had a kidney transplant from a matched sibling donor for at least one year with no history of rejection.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
donor hematopoietic stem cells and T-cells
What this could lead to
If successful, this could allow kidney transplant recipients to stop taking lifelong immunosuppressive drugs without rejecting their kidney.
What could go wrong
This is an early-phase trial with only 25 participants. The conditioning regimen carries risks of infection, graft failure, or rejection, and the approach may not work for everyone.
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Locations
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Stanford University Medical Center
RECRUITINGPalo Alto, California, 94304, United States
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