New triple therapy shows promise in kidney cancer battle

NCT ID NCT03937219

Ongoing Disease control Sponsor: Exelixis Source: ClinicalTrials.gov ↗

First seen Nov 01, 2025 · Last updated May 13, 2026 · Updated 20 times

Summary

This study tests whether adding the targeted drug cabozantinib to a standard immunotherapy combo (nivolumab and ipilimumab) helps people with advanced kidney cancer live longer without their cancer growing. About 855 adults with intermediate- or high-risk kidney cancer that has spread will take part. The goal is to see if the three-drug combination is more effective than the two-drug approach.

Disclaimer Read more

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

Get updates

Get notified about this study

Our safety recommendation!

By submitting, you agree to our Terms of use

Contacts and locations

Show contact details

Locations

Exelixis Clincal Site #129

Ramat Gan, 5265601, Israel
Exelixis Clinical Site #1

Spokane, Washington, 99208, United States
Exelixis Clinical Site #10

Nashville, Tennessee, 37203, United States
Exelixis Clinical Site #100

Santiago, 8420383, Chile
Exelixis Clinical Site #101

Charlotte, North Carolina, 28204, United States
Exelixis Clinical Site #102

Charleston, South Carolina, 29425, United States
Exelixis Clinical Site #104

Perugia, 06132, Italy
Exelixis Clinical Site #105

Winnipeg, Manitoba, R3E 0V9, Canada
Exelixis Clinical Site #107

Portland, Oregon, 97239, United States
Exelixis Clinical Site #109

Rosario, Santa Fe Province, S2000KZE, Argentina
Exelixis Clinical Site #11

North Adelaide, South Australia, 5006, Australia
Exelixis Clinical Site #110

Ciudad Autonoma de Buenos Aire, C1426ANZ, Argentina
Exelixis Clinical Site #111

Tuenmen, Hong Kong
Exelixis Clinical Site #112

Brussels, 1000, Belgium
Exelixis Clinical Site #113

Montreal, Quebec, H3T 1E2, Canada
Exelixis Clinical Site #114

Prague, 140 59, Czechia
Exelixis Clinical Site #115

Tübingen, Baden-Wurttemberg, 72076, Germany
Exelixis Clinical Site #116

La Jolla, California, 92093, United States
Exelixis Clinical Site #117

Frankfurt am Main, Hesse, 60596, Germany
Exelixis Clinical Site #118

Prague, 150 06, Czechia
Exelixis Clinical Site #119

São Paulo, 01323-001, Brazil
Exelixis Clinical Site #12

Pittsburgh, Pennsylvania, 15232, United States
Exelixis Clinical Site #120

Córdoba, X5004, Argentina
Exelixis Clinical Site #121

Kfar Saba, 4428164, Israel
Exelixis Clinical Site #122

Hamilton, Waikato Region, 3204, New Zealand
Exelixis Clinical Site #123

Aguascalientes, Aguascalientes, 20116, Mexico
Exelixis Clinical Site #124

Dresden, 01307, Germany
Exelixis Clinical Site #125

Rennes, 35042, France
Exelixis Clinical Site #126

Vienna, 1090, Austria
Exelixis Clinical Site #127

Heidelberg, Baden-Wurttemberg, 69120, Germany
Exelixis Clinical Site #128

Strasbourg, 67000, France
Exelixis Clinical Site #13

Madison, Wisconsin, 53792, United States
Exelixis Clinical Site #131

Querétaro, 76000, Mexico
Exelixis Clinical Site #132

Oaxaca City, Oaxaca, 68000, Mexico
Exelixis Clinical Site #134

Monterrey, Nuevo León, 64710, Mexico
Exelixis Clinical Site #135

Gdansk, 80-219, Poland
Exelixis Clinical Site #136

Shatin, Hong Kong
Exelixis Clinical Site #137

Jena, Thuringia, 077477, Germany
Exelixis Clinical Site #138

Taipei, 10002, Taiwan
Exelixis Clinical Site #139

Münster, North Rhine-Westphalia, 48149, Germany
Exelixis Clinical Site #14

Woolloongabba, Queensland, 4102, Australia
Exelixis Clinical Site #140

Porto Alegre, Rio Grande do Sul, 90110-270, Brazil
Exelixis Clinical Site #141

São Paulo, 01327-001, Brazil
Exelixis Clinical Site #142

Taichung, 404, Taiwan
Exelixis Clinical Site #143

Seoul, 03722, South Korea
Exelixis Clinical Site #144

Amsterdam, 1105 AZ, Netherlands
Exelixis Clinical Site #146

Hasselt, 3500, Belgium
Exelixis Clinical Site #147

Seongnam-si, Gyeonggi-do, 13620, South Korea
Exelixis Clinical Site #148

Newtown, Wellington Region, 6021, New Zealand
Exelixis Clinical Site #149

Rotterdam, 3015 GD, Netherlands
Exelixis Clinical Site #15

Detroit, Michigan, 48201, United States
Exelixis Clinical Site #150

Paris, 75015, France
Exelixis Clinical Site #151

Seoul, 05505, South Korea
Exelixis Clinical Site #152

Seoul, 06351, South Korea
Exelixis Clinical Site #153

Pilar, Buenos Aires, B1629ODT, Argentina
Exelixis Clinical Site #154

Belo Horizonte, Minas Gerais, 30130-090, Brazil
Exelixis Clinical Site #155

Curitiba, Paraná, 80530-010, Brazil
Exelixis Clinical Site #158

Porto Alegre, Rio Grande do Sul, 90050-170, Brazil
Exelixis Clinical Site #159

New York, New York, 10032, United States
Exelixis Clinical Site #160

Mexico City, 03100, Mexico
Exelixis Clinical Site #161

Querétaro, 76090, Mexico
Exelixis Clinical Site #162

São José do Rio Preto, São Paulo, 15090-000, Brazil
Exelixis Clinical Site #163

Porto Alegre, Rio Grande do Sul, 90610-000, Brazil
Exelixis Clinical Site #164

Mainz, Rhineland-Palatinate, 55131, Germany
Exelixis Clinical Site #166

Orange, California, 92868-3201, United States
Exelixis Clinical Site #167

León, Guanajuato, 37000, Mexico
Exelixis Clinical Site #168

Barretos, São Paulo, 14784-400, Brazil
Exelixis Clinical Site #169

Zapopan, Jalisco, 45070, Mexico
Exelixis Clinical Site #17

South Brisbane, Queensland, 4101, Australia
Exelixis Clinical Site #171

Münster, North Rhine-Westphalia, 90419, Germany
Exelixis Clinical Site #172

London, W6 8RF, United Kingdom
Exelixis Clinical Site #173

Taoyuan, 333, Taiwan
Exelixis Clinical Site #18

Adelaide, South Australia, 5000, Australia
Exelixis Clinical Site #19

Syracuse, New York, 13210, United States
Exelixis Clinical Site #2

Omaha, Nebraska, 68130, United States
Exelixis Clinical Site #20

Madrid, 28041, Spain
Exelixis Clinical Site #22

Calgary, Alberta, T2N 4N2, Canada
Exelixis Clinical Site #23

Box Hill, Victoria, 3128, Australia
Exelixis Clinical Site #24

Kansas City, Missouri, 64132, United States
Exelixis Clinical Site #25

Toronto, Ontario, M4N 3M5, Canada
Exelixis Clinical Site #26

Subiaco, Western Australia, 6008, Australia
Exelixis Clinical Site #27

North Ryde, New South Wales, 2109, Australia
Exelixis Clinical Site #28

Hong Kong, Hong Kong
Exelixis Clinical Site #29

Boca Raton, Florida, 33486, United States
Exelixis Clinical Site #3

Atlanta, Georgia, 30318, United States
Exelixis Clinical Site #30

London, EC1A 7BE, United Kingdom
Exelixis Clinical Site #31

Biała Podlaska, 21-500, Poland
Exelixis Clinical Site #32

Albury, New South Wales, 2640, Australia
Exelixis Clinical Site #33

Sydney, New South Wales, 2065, Australia
Exelixis Clinical Site #34

Madrid, 28009, Spain
Exelixis Clinical Site #35

Kogarah, New South Wales, 2217, Australia
Exelixis Clinical Site #36

Barcelona, 08036, Spain
Exelixis Clinical Site #37

Villejuif, 94800, France
Exelixis Clinical Site #38

Nashville, Tennessee, 37232, United States
Exelixis Clinical Site #39

Budapest, 1122, Hungary
Exelixis Clinical Site #4

St Louis, Missouri, 63110, United States
Exelixis Clinical Site #40

Singapore, 169610, Singapore
Exelixis Clinical Site #41

Meldola, Forli - Cesena, 47014, Italy
Exelixis Clinical Site #42

Toulouse, 31059, France
Exelixis Clinical Site #43

Barcelona, 08035, Spain
Exelixis Clinical Site #44

Miami, Florida, 33176, United States
Exelixis Clinical Site #45

Pamplona, Navarre, 31008, Spain
Exelixis Clinical Site #46

Ottawa, Ontario, K1H 8L6, Canada
Exelixis Clinical Site #47

Arezzo, 52100, Italy
Exelixis Clinical Site #49

Córdoba, 14004, Spain
Exelixis Clinical Site #5

Myrtle Beach, South Carolina, 29572, United States
Exelixis Clinical Site #50

Helsinki, 00029, Finland
Exelixis Clinical Site #51

Pécs, 7624, Hungary
Exelixis Clinical Site #52

Turku, 20520, Finland
Exelixis Clinical Site #53

Santiago de Compostela, Coruña, 15706, Spain
Exelixis Clinical Site #54

Buenos Aires, C1125ABD, Argentina
Exelixis Clinical Site #55

Madrid, 28050, Spain
Exelixis Clinical Site #56

Tampere, 33520, Finland
Exelixis Clinical Site #57

Seattle, Washington, 98109, United States
Exelixis Clinical Site #58A

Baltimore, Maryland, 21287, United States
Exelixis Clinical Site #59

Pavia, 27100, Italy
Exelixis Clinical Site #6

Burlington, Massachusetts, 01805, United States
Exelixis Clinical Site #60

Modena, 41124, Italy
Exelixis Clinical Site #61

Padova, 35128, Italy
Exelixis Clinical Site #62

Bydgoszcz, 85-796, Poland
Exelixis Clinical Site #63

CABA, C1120AAT, Argentina
Exelixis Clinical Site #64

Fairfax, Virginia, 22031, United States
Exelixis Clinical Site #65

Reims, 51726, France
Exelixis Clinical Site #66

Nice, 06189, France
Exelixis Clinical Site #67

Vandœuvre-lès-Nancy, 54519, France
Exelixis Clinical Site #68

Terni, 05100, Italy
Exelixis Clinical Site #69

Scarborough, Maine, 04074, United States
Exelixis Clinical Site #70

Faenza, Ravenna, 48018, Italy
Exelixis Clinical Site #71

Le Mans, 72000, France
Exelixis Clinical Site #72

Cambridge, CB2 0QQ, United Kingdom
Exelixis Clinical Site #73

San Miguel de Tucumán, Tucumán Province, T4000, Argentina
Exelixis Clinical Site #74

Valencia, 46009, Spain
Exelixis Clinical Site #75

Salzburg, 5020, Austria
Exelixis Clinical Site #76

Linz, Upper Austria, 4020, Austria
Exelixis Clinical Site #77

Singapore, 119074, Singapore
Exelixis Clinical Site #78

Lyon, 69373, France
Exelixis Clinical Site #7A

Boston, Massachusetts, 02215, United States
Exelixis Clinical Site #7B

Boston, Massachusetts, 02114, United States
Exelixis Clinical Site #7C

Boston, Massachusetts, 02215, United States
Exelixis Clinical Site #8

New York, New York, 10065, United States
Exelixis Clinical Site #80

Montpellier, 34295, France
Exelixis Clinical Site #81

Haifa, 3109601, Israel
Exelixis Clinical Site #83

Poznan, 60-693, Poland
Exelixis Clinical Site #84

Jerusalem, 9112001, Israel
Exelixis Clinical Site #85

Temuco, Región de La Araucanía (IX), 4810561, Chile
Exelixis Clinical Site #86

Bordeaux, 33075, France
Exelixis Clinical Site #88

Beersheba, 84101, Israel
Exelixis Clinical Site #89

Králová, 50005, Czechia
Exelixis Clinical Site #9

Ballarat, Victoria, 3350, Australia
Exelixis Clinical Site #90

Strasbourg, 67200, France
Exelixis Clinical Site #91

Santiago, 7500921, Chile
Exelixis Clinical Site #92

Manchester, M20 4BX, United Kingdom
Exelixis Clinical Site #93

Glasgow, G12 0YN, United Kingdom
Exelixis Clinical Site #94

Madrid, 28040, Spain
Exelixis Clinical Site #95

Chicago, Illinois, 60612, United States
Exelixis Clinical Site #96

Oviedo, 33011, Spain
Exelixis Clinical Site #97

Petah Tikva, 49100, Israel
Exelixis Clinical Site #98

Wiener Neustadt, Lower Austria, 2700, Austria
Exelixis Clinical Site #99

Otwock, 05-400, Poland

Conditions

Explore the condition pages connected to this study.

RENAL CELL CARCINOMA