New drug duo tested in fight against rare, aggressive kidney cancer

NCT ID NCT03595124

Ongoing Disease control Sponsor: National Cancer Institute (NCI) Source: ClinicalTrials.gov ↗

Summary

This study is testing whether combining two cancer drugs works better than using just one to treat an aggressive form of kidney cancer that has spread or cannot be removed by surgery. The trial is enrolling patients of all ages, from children to adults. Researchers want to see if the drug combination can better control the cancer's growth and spread.

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes NO responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

Get updates

Get notified about this study

Our safety recommendation!

By submitting, you agree to our Terms of use

Contacts and locations

Show contact details

Locations

Abbott-Northwestern Hospital

Minneapolis, Minnesota, 55407, United States
AdventHealth Littleton

Littleton, Colorado, 80122, United States
AdventHealth Parker

Parker, Colorado, 80138, United States
AdventHealth Porter

Denver, Colorado, 80210, United States
Albany Medical Center

Albany, New York, 12208, United States
Alegent Health Bergan Mercy Medical Center

Omaha, Nebraska, 68124, United States
Alegent Health Immanuel Medical Center

Omaha, Nebraska, 68122, United States
Alegent Health Lakeside Hospital

Omaha, Nebraska, 68130, United States
Alegent Health Mercy Hospital

Council Bluffs, Iowa, 51503, United States
Alfred I duPont Hospital for Children

Wilmington, Delaware, 19803, United States
Alliance for Childhood Diseases/Cure 4 the Kids Foundation

Las Vegas, Nevada, 89135, United States
Ann M Wierman MD LTD

Las Vegas, Nevada, 89128, United States
Arkansas Children's Hospital

Little Rock, Arkansas, 72202-3591, United States
Baystate Medical Center

Springfield, Massachusetts, 01199, United States
Bethesda North Hospital

Cincinnati, Ohio, 45242, United States
Broward Health Medical Center

Fort Lauderdale, Florida, 33316, United States
C S Mott Children's Hospital

Ann Arbor, Michigan, 48109, United States
CHI Health Good Samaritan

Kearney, Nebraska, 68847, United States
CHI Saint Vincent Cancer Center Hot Springs

Hot Springs, Arkansas, 71913, United States
CTCA at Western Regional Medical Center

Goodyear, Arizona, 85338, United States
Cambridge Medical Center

Cambridge, Minnesota, 55008, United States
Cancer Care Specialists - Reno

Reno, Nevada, 89511, United States
Cancer Center at Saint Joseph's

Phoenix, Arizona, 85004, United States
Cancer Center of Western Wisconsin

New Richmond, Wisconsin, 54017, United States
Cancer Therapy and Integrative Medicine

Las Vegas, Nevada, 89121, United States
Cancer Treatment Centers of America

Tulsa, Oklahoma, 74133, United States
Cancer and Blood Specialists-Henderson

Henderson, Nevada, 89052, United States
Cancer and Blood Specialists-Shadow

Las Vegas, Nevada, 89106, United States
Cancer and Blood Specialists-Tenaya

Las Vegas, Nevada, 89128, United States
Cardinal Glennon Children's Medical Center

St Louis, Missouri, 63104, United States
Carle Cancer Center

Urbana, Illinois, 61801, United States
Carle Physician Group-Effingham

Effingham, Illinois, 62401, United States
Carle Physician Group-Mattoon/Charleston

Mattoon, Illinois, 61938, United States
Carle at The Riverfront

Danville, Illinois, 61832, United States
Carolinas Medical Center/Levine Cancer Institute

Charlotte, North Carolina, 28203, United States
Carson Tahoe Regional Medical Center

Carson City, Nevada, 89703, United States
Case Western Reserve University

Cleveland, Ohio, 44106, United States
Children's Healthcare of Atlanta - Arthur M Blank Hospital

Atlanta, Georgia, 30329, United States
Children's Hospital Colorado

Aurora, Colorado, 80045, United States
Children's Hospital Medical Center of Akron

Akron, Ohio, 44308, United States
Children's Hospital of Alabama

Birmingham, Alabama, 35233, United States
Children's Hospital of Orange County

Orange, California, 92868, United States
Children's Hospital of Philadelphia

Philadelphia, Pennsylvania, 19104, United States
Children's Hospital of Pittsburgh of UPMC

Pittsburgh, Pennsylvania, 15224, United States
Children's Hospital of San Antonio

San Antonio, Texas, 78207, United States
Children's Hospital of The King's Daughters

Norfolk, Virginia, 23507, United States
Children's Hospital of Wisconsin

Milwaukee, Wisconsin, 53226, United States
Children's Hospitals and Clinics of Minnesota - Minneapolis

Minneapolis, Minnesota, 55404, United States
Children's Mercy Hospitals and Clinics

Kansas City, Missouri, 64108, United States
Children's National Medical Center

Washington D.C., District of Columbia, 20010, United States
Cincinnati Children's Hospital Medical Center

Cincinnati, Ohio, 45229, United States
Cleveland Clinic Foundation

Cleveland, Ohio, 44195, United States
CommonSpirit Cancer Center Mercy

Durango, Colorado, 81301, United States
Commonwealth Cancer Center-Corbin

Corbin, Kentucky, 40701, United States
Comprehensive Cancer Centers of Nevada

Las Vegas, Nevada, 89148, United States
Comprehensive Cancer Centers of Nevada - Central Valley

Las Vegas, Nevada, 89169, United States
Comprehensive Cancer Centers of Nevada - Henderson

Henderson, Nevada, 89052, United States
Comprehensive Cancer Centers of Nevada - Northwest

Las Vegas, Nevada, 89128, United States
Comprehensive Cancer Centers of Nevada - Town Center

Las Vegas, Nevada, 89144, United States
Comprehensive Cancer Centers of Nevada-Horizon Ridge

Henderson, Nevada, 89052, United States
Comprehensive Cancer Centers of Nevada-Southeast Henderson

Henderson, Nevada, 89074, United States
Comprehensive Cancer Centers of Nevada-Summerlin

Las Vegas, Nevada, 89144, United States
Connecticut Children's Medical Center

Hartford, Connecticut, 06106, United States
Cook Children's Medical Center

Fort Worth, Texas, 76104, United States
Creighton University Medical Center

Omaha, Nebraska, 68131, United States
Dana-Farber Cancer Institute

Boston, Massachusetts, 02215, United States
Dayton Children's Hospital

Dayton, Ohio, 45404, United States
Dell Children's Medical Center of Central Texas

Austin, Texas, 78723, United States
Desert West Surgery

Las Vegas, Nevada, 89102, United States
East Tennessee Childrens Hospital

Knoxville, Tennessee, 37916, United States
El Paso Children's Hospital

El Paso, Texas, 79905, United States
Fairview Clinics and Surgery Center Maple Grove

Maple Grove, Minnesota, 55369, United States
Fairview Lakes Medical Center

Wyoming, Minnesota, 55092, United States
Fairview Northland Medical Center

Princeton, Minnesota, 55371, United States
Fairview Ridges Hospital

Burnsville, Minnesota, 55337, United States
Fairview Southdale Hospital

Edina, Minnesota, 55435, United States
Flaget Memorial Hospital

Bardstown, Kentucky, 40004, United States
Fox Chase Cancer Center

Philadelphia, Pennsylvania, 19111, United States
Franciscan Research Center-Northwest Medical Plaza

Tacoma, Washington, 98405, United States
Fred and Pamela Buffett Cancer Center - Kearney

Kearney, Nebraska, 68845, United States
Golisano Children's Hospital of Southwest Florida

Fort Myers, Florida, 33908, United States
Good Samaritan Hospital - Cincinnati

Cincinnati, Ohio, 45220, United States
Greater Regional Medical Center

Creston, Iowa, 50801, United States
HIMA San Pablo Oncologic Hospital

Caguas, 00726, Puerto Rico
HSHS Saint Nicholas Hospital

Sheboygan, Wisconsin, 53081, United States
Hackensack University Medical Center

Hackensack, New Jersey, 07601, United States
Harrison HealthPartners Hematology and Oncology-Poulsbo

Poulsbo, Washington, 98370, United States
Health Partners Inc

Minneapolis, Minnesota, 55454, United States
HealthCare Partners Medical Group Oncology/Hematology-Centennial Hills

Las Vegas, Nevada, 89149, United States
HealthCare Partners Medical Group Oncology/Hematology-Maryland Parkway

Las Vegas, Nevada, 89109, United States
HealthCare Partners Medical Group Oncology/Hematology-San Martin

Las Vegas, Nevada, 89113, United States
HealthCare Partners Medical Group Oncology/Hematology-Tenaya

Las Vegas, Nevada, 89128, United States
Hematology and Oncology Consultants PC

Omaha, Nebraska, 68122, United States
Hennepin County Medical Center

Minneapolis, Minnesota, 55415, United States
Henry Ford Health Saint John Hospital

Detroit, Michigan, 48236, United States
Highline Medical Center-Main Campus

Burien, Washington, 98166, United States
Holy Family Memorial Hospital

Manitowoc, Wisconsin, 54221, United States
Hope Cancer Care of Nevada

Las Vegas, Nevada, 89103, United States
Hope Cancer Care of Nevada-Pahrump

Pahrump, Nevada, 89048, United States
Huron Medical Center PC

Port Huron, Michigan, 48060, United States
Jewish Hospital

Louisville, Kentucky, 40202, United States
Jewish Hospital Medical Center South

Shepherdsville, Kentucky, 40165, United States
Kaiser Permanente Downey Medical Center

Downey, California, 90242, United States
Kaiser Permanente Los Angeles Medical Center

Los Angeles, California, 90027, United States
Kaiser Permanente-Anaheim

Anaheim, California, 92806, United States
Kaiser Permanente-Bellflower

Bellflower, California, 90706, United States
Kaiser Permanente-Fontana

Fontana, California, 92335, United States
Kaiser Permanente-Oakland

Oakland, California, 94611, United States
Kaiser Permanente-San Diego Mission

San Diego, California, 92108, United States
Kapiolani Medical Center for Women and Children

Honolulu, Hawaii, 96826, United States
Lake Huron Medical Center

Port Huron, Michigan, 48060, United States
Lakeview Hospital

Stillwater, Minnesota, 55082, United States
Las Vegas Cancer Center-Henderson

Henderson, Nevada, 89052, United States
Las Vegas Cancer Center-Medical Center

Las Vegas, Nevada, 89148-2405, United States
Las Vegas Urology - Green Valley

Henderson, Nevada, 89074, United States
Las Vegas Urology - Sunset

Las Vegas, Nevada, 89113, United States
Legacy Emanuel Children's Hospital

Portland, Oregon, 97227, United States
Longmont United Hospital

Longmont, Colorado, 80501, United States
M D Anderson Cancer Center

Houston, Texas, 77030, United States
Maimonides Medical Center

Brooklyn, New York, 11219, United States
Marshfield Medical Center-Marshfield

Marshfield, Wisconsin, 54449, United States
Mary Bridge Children's Hospital and Health Center

Tacoma, Washington, 98405, United States
Mattel Children's Hospital UCLA

Los Angeles, California, 90095, United States
Medical University of South Carolina

Charleston, South Carolina, 29425, United States
Memorial GYN Plus

Ooltewah, Tennessee, 37363, United States
Memorial Hospital

Chattanooga, Tennessee, 37404, United States
Memorial Sloan Kettering Cancer Center

New York, New York, 10065, United States
Mercy Cancer Center - Carmichael

Carmichael, California, 95608, United States
Mercy Cancer Center - Elk Grove

Elk Grove, California, 95758, United States
Mercy Cancer Center - Rocklin

Rocklin, California, 95765, United States
Mercy Cancer Center - Sacramento

Sacramento, California, 95816, United States
Mercy Cancer Center-West Lakes

Clive, Iowa, 50325, United States
Mercy Hospital

Coon Rapids, Minnesota, 55433, United States
Mercy Hospital Saint Louis

St Louis, Missouri, 63141, United States
Mercy Medical Center

Durango, Colorado, 81301, United States
Mercy Medical Center - Des Moines

Des Moines, Iowa, 50314, United States
Mercy Medical Center-West Lakes

West Des Moines, Iowa, 50266, United States
Mercy San Juan Medical Center

Carmichael, California, 95608, United States
Methodist Children's Hospital of South Texas

San Antonio, Texas, 78229, United States
Midlands Community Hospital

Papillion, Nebraska, 68046, United States
Minnesota Oncology - Burnsville

Burnsville, Minnesota, 55337, United States
Minnesota Oncology Hematology PA-Maplewood

Maplewood, Minnesota, 55109, United States
Minnesota Oncology Hematology PA-Woodbury

Woodbury, Minnesota, 55125, United States
Mission Hope Medical Oncology - Arroyo Grande

Arroyo Grande, California, 93420, United States
Mission Hope Medical Oncology - Santa Maria

Santa Maria, California, 93444, United States
Mission Hospital

Asheville, North Carolina, 28801, United States
Montefiore Medical Center - Moses Campus

The Bronx, New York, 10467, United States
Monticello Cancer Center

Monticello, Minnesota, 55362, United States
Mountain Blue Cancer Care Center

Golden, Colorado, 80401, United States
NYP/Columbia University Medical Center/Herbert Irving Comprehensive Cancer Center

New York, New York, 10032, United States
Nationwide Children's Hospital

Columbus, Ohio, 43205, United States
Nebraska Cancer Specialists/Oncology Hematology West PC

Grand Island, Nebraska, 68803, United States
Nemours Children's Clinic-Jacksonville

Jacksonville, Florida, 32207, United States
Nemours Children's Hospital

Orlando, Florida, 32827, United States
New Ulm Medical Center

New Ulm, Minnesota, 56073, United States
Nicklaus Children's Hospital

Miami, Florida, 33155, United States
North Memorial Medical Health Center

Robbinsdale, Minnesota, 55422, United States
North Star Lodge Cancer Center at Yakima Valley Memorial Hospital

Yakima, Washington, 98902, United States
Northwest Medical Specialties PLLC

Tacoma, Washington, 98405, United States
Northwestern Medicine Lake Forest Hospital

Lake Forest, Illinois, 60045, United States
Northwestern University

Chicago, Illinois, 60611, United States
Norton Children's Hospital

Louisville, Kentucky, 40202, United States
Ochsner Medical Center Jefferson

New Orleans, Louisiana, 70121, United States
Oncology Las Vegas - Henderson

Henderson, Nevada, 89074, United States
Oncology Las Vegas - Tenaya

Las Vegas, Nevada, 89128, United States
OptumCare Cancer Care at Charleston

Las Vegas, Nevada, 89102, United States
OptumCare Cancer Care at Fort Apache

Las Vegas, Nevada, 89148, United States
OptumCare Cancer Care at MountainView

Las Vegas, Nevada, 89128, United States
OptumCare Cancer Care at Seven Hills

Henderson, Nevada, 89052, United States
Oregon Health and Science University

Portland, Oregon, 97239, United States
Overlake Medical Center

Bellevue, Washington, 98004, United States
PCR Oncology

Arroyo Grande, California, 93420, United States
Pacific Central Coast Health Center-San Luis Obispo

San Luis Obispo, California, 93401, United States
Park Nicollet Clinic - Saint Louis Park

Saint Louis Park, Minnesota, 55416, United States
Penrose-Saint Francis Healthcare

Colorado Springs, Colorado, 80907, United States
Presbyterian - Saint Lukes Medical Center - Health One

Denver, Colorado, 80218, United States
Primary Children's Hospital

Salt Lake City, Utah, 84113, United States
Prisma Health Cancer Institute - Butternut

Greenville, South Carolina, 29605, United States
Prisma Health Cancer Institute - Easley

Easley, South Carolina, 29640, United States
Prisma Health Cancer Institute - Eastside

Greenville, South Carolina, 29615, United States
Prisma Health Cancer Institute - Faris

Greenville, South Carolina, 29605, United States
Prisma Health Cancer Institute - Greer

Greer, South Carolina, 29650, United States
Prisma Health Cancer Institute - Laurens

Clinton, South Carolina, 29325, United States
Prisma Health Cancer Institute - Seneca

Seneca, South Carolina, 29672, United States
Prisma Health Cancer Institute - Spartanburg

Boiling Springs, South Carolina, 29316, United States
ProMedica Flower Hospital

Sylvania, Ohio, 43560, United States
ProMedica Toledo Hospital/Russell J Ebeid Children's Hospital

Toledo, Ohio, 43606, United States
Providence Sacred Heart Medical Center and Children's Hospital

Spokane, Washington, 99204, United States
Pulmonary Medicine Center of Chattanooga-Hixson

Hixson, Tennessee, 37343, United States
Radiation Oncology Associates

Reno, Nevada, 89509, United States
Radiation Oncology Centers of Nevada Central

Las Vegas, Nevada, 89106, United States
Radiation Oncology Centers of Nevada Southeast

Las Vegas, Nevada, 89119, United States
Rainbow Babies and Childrens Hospital

Cleveland, Ohio, 44106, United States
Regions Hospital

Saint Paul, Minnesota, 55101, United States
Renown Regional Medical Center

Reno, Nevada, 89502, United States
Rice Memorial Hospital

Willmar, Minnesota, 56201, United States
Ridgeview Medical Center

Waconia, Minnesota, 55387, United States
Riley Hospital for Children

Indianapolis, Indiana, 46202, United States
Rocky Mountain Cancer Centers - Pueblo

Pueblo, Colorado, 81008, United States
Rocky Mountain Cancer Centers-Lakewood

Lakewood, Colorado, 80228, United States
Rocky Mountain Cancer Centers-Longmont

Longmont, Colorado, 80501, United States
Rocky Mountain Cancer Centers-Parker

Parker, Colorado, 80138, United States
Rocky Mountain Cancer Centers-Penrose

Colorado Springs, Colorado, 80907, United States
Rocky Mountain Cancer Centers-Thornton

Thornton, Colorado, 80260, United States
Rocky Mountain Hospital for Children-Presbyterian Saint Luke's Medical Center

Denver, Colorado, 80218, United States
Rush MD Anderson Cancer Center

Chicago, Illinois, 60612, United States
Saint Anthony Hospital

Lakewood, Colorado, 80228, United States
Saint Clare Hospital

Lakewood, Washington, 98499, United States
Saint Elizabeth Hospital

Enumclaw, Washington, 98022, United States
Saint Elizabeth Regional Medical Center

Lincoln, Nebraska, 68510, United States
Saint Francis Cancer Center

Colorado Springs, Colorado, 80923, United States
Saint Francis Hospital

Federal Way, Washington, 98003, United States
Saint Francis Regional Medical Center

Shakopee, Minnesota, 55379, United States
Saint John's Hospital - Healtheast

Maplewood, Minnesota, 55109, United States
Saint Joseph Hospital

Lexington, Kentucky, 40504, United States
Saint Joseph Hospital East

Lexington, Kentucky, 40509, United States
Saint Joseph London

London, Kentucky, 40741, United States
Saint Joseph Mount Sterling

Mount Sterling, Kentucky, 40353, United States
Saint Joseph Radiation Oncology Resource Center

Lexington, Kentucky, 40504, United States
Saint Joseph Regional Cancer Center

Bryan, Texas, 77802, United States
Saint Joseph's Hospital/Children's Hospital-Tampa

Tampa, Florida, 33607, United States
Saint Jude Children's Research Hospital

Memphis, Tennessee, 38105, United States
Saint Jude Midwest Affiliate

Peoria, Illinois, 61637, United States
Saint Mary Corwin Medical Center

Pueblo, Colorado, 81004, United States
Saint Mary's Medical Center

West Palm Beach, Florida, 33407, United States
Saint Mary's Regional Medical Center

Reno, Nevada, 89503, United States
Saint Michael Cancer Center

Silverdale, Washington, 98383, United States
Saint Vincent Hospital Cancer Center Green Bay

Green Bay, Wisconsin, 54301, United States
Saint Vincent Hospital Cancer Center at Marinette

Marinette, Wisconsin, 54143, United States
Saint Vincent Hospital Cancer Center at Oconto Falls

Oconto Falls, Wisconsin, 54154, United States
Saint Vincent Hospital Cancer Center at Saint Mary's

Green Bay, Wisconsin, 54303, United States
Saint Vincent Hospital Cancer Center at Sturgeon Bay

Sturgeon Bay, Wisconsin, 54235-1495, United States
Saints Mary and Elizabeth Hospital

Louisville, Kentucky, 40215, United States
Seattle Children's Hospital

Seattle, Washington, 98105, United States
Sinai Hospital of Baltimore

Baltimore, Maryland, 21215, United States
State University of New York Upstate Medical University

Syracuse, New York, 13210, United States
Summerlin Hospital Medical Center

Las Vegas, Nevada, 89144, United States
Sunrise Hospital and Medical Center

Las Vegas, Nevada, 89109, United States
The Carle Foundation Hospital

Urbana, Illinois, 61801, United States
The Children's Hospital at TriStar Centennial

Nashville, Tennessee, 37203, United States
The Steven and Alexandra Cohen Children's Medical Center of New York

New Hyde Park, New York, 11040, United States
TriHealth Cancer Institute-Anderson

Cincinnati, Ohio, 45255, United States
TriHealth Cancer Institute-Westside

Cincinnati, Ohio, 45247, United States
UCHealth University of Colorado Hospital

Aurora, Colorado, 80045, United States
UF Health Cancer Institute - Gainesville

Gainesville, Florida, 32610, United States
UI Health Care Mission Cancer and Blood - Laurel Clinic

Des Moines, Iowa, 50314, United States
UI Health Care Mission Cancer and Blood - West Des Moines Clinic

Clive, Iowa, 50325, United States
UNC Lineberger Comprehensive Cancer Center

Chapel Hill, North Carolina, 27599, United States
United Hospital

Saint Paul, Minnesota, 55102, United States
Unity Hospital

Fridley, Minnesota, 55432, United States
University Cancer Center

Las Vegas, Nevada, 89169, United States
University Hospital

San Antonio, Texas, 78229, United States
University Medical Center of Southern Nevada

Las Vegas, Nevada, 89102, United States
University of California Davis Comprehensive Cancer Center

Sacramento, California, 95817, United States
University of Chicago Comprehensive Cancer Center

Chicago, Illinois, 60637, United States
University of Iowa/Holden Comprehensive Cancer Center

Iowa City, Iowa, 52242, United States
University of Miami Miller School of Medicine-Sylvester Cancer Center

Miami, Florida, 33136, United States
University of Mississippi Medical Center

Jackson, Mississippi, 39216, United States
University of Oklahoma Health Sciences Center

Oklahoma City, Oklahoma, 73104, United States
University of Texas Health Science Center at San Antonio

San Antonio, Texas, 78229, United States
University of Virginia Cancer Center

Charlottesville, Virginia, 22908, United States
UofL Health Medical Center Northeast

Louisville, Kentucky, 40245, United States
Urology Specialists of Nevada - Central

Las Vegas, Nevada, 89106, United States
Urology Specialists of Nevada - Green Valley

Henderson, Nevada, 89074, United States
Urology Specialists of Nevada - Northwest

Las Vegas, Nevada, 89128, United States
Urology Specialists of Nevada - Southwest

Las Vegas, Nevada, 89113, United States
Washington University School of Medicine

St Louis, Missouri, 63110, United States
West Virginia University Charleston Division

Charleston, West Virginia, 25304, United States
Woodland Memorial Hospital

Woodland, California, 95695, United States

Conditions

Explore the condition pages connected to this study.

METASTATIC RENAL CELL CARCINOMA STAGE III RENAL CELL CANCER AJCC V8 STAGE IV RENAL CELL CANCER AJCC V8 TFE3-REARRANGED RENAL CELL CARCINOMA UNRESECTABLE RENAL CELL CARCINOMA