New dosing schedule could ease sickle cell treatment for kids
NCT ID NCT06578507
First seen Jun 26, 2026 · Last updated Jun 26, 2026
Summary
This study is testing whether giving hydroxyurea twice a day works better than the usual once-daily dose for children with sickle cell disease. About 50 children aged 9 months to 11 years will take the drug for 12 months. Researchers will measure how the drug behaves in the body and whether it helps control the disease.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- Hydroxyurea (hydroxycarbamide) dispersible tablets
- What this could lead to
- If successful, this could offer a more convenient twice-daily dosing option for children with sickle cell disease, potentially improving adherence and disease control.
- What could go wrong
- This is a small, early-phase study with only 50 children and no comparison group. It may not show clear benefits, and side effects like bone marrow suppression are possible.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Centre Hospitalier Intercommunal Créteil
RECRUITINGCréteil, France
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Centre hospitalier de Cayenne
RECRUITINGCayenne, French Guiana
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GHEF- Site de Marne-la-Vallée
RECRUITINGJossigny, France
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Hôpital Bicêtre
RECRUITINGLe Kremlin-Bicêtre, France
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Hôpital Necker-Enfants malades
RECRUITINGParis, France
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Institut d'Hématologie et d'oncologie pédiatrique - IHOPe
ACTIVE_NOT_RECRUITINGLyon, France
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- A Pocket-Sized coach for sickle cell: can an app turn Pill-Taking into a habit?
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- A common amino acid may calm sickle cell pain crises — a trial puts it to the test
- A drug that protects the liver may make stem cell transplants safer for children with sickle cell disease