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New eye drops aim to ease painful corneal scratches in rare skin disease

NCT ID NCT07016750

Recruiting now Disease control Sponsor: Krystal Biotech, Inc. Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests an eye drop called KB803 in 16 people aged 6 months and older with dystrophic epidermolysis bullosa (DEB), a rare genetic condition causing fragile skin and recurrent corneal abrasions. Participants will receive both KB803 and a placebo in random order to see if the drops reduce the number of days with corneal abrasion symptoms and eye pain. The goal is to find a safe treatment that helps manage this painful eye complication.

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Conditions

The condition(s) this trial relates to.

Corneal Injuries dystrophic epidermolysis bullosa, dog epidermolysis bullosa dystrophica generalized dominant dystrophic epidermolysis bullosa recessive dystrophic epidermolysis bullosa

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

DEB - DYSTROPHIC EPIDERMOLYSIS BULLOSA DOMINANT DYSTROPHIC EPIDERMOLYSIS BULLOSA DYSTROPHIC EPIDERMOLYSIS BULLOSA RECESSIVE DYSTROPHIC EPIDERMOLYSIS BULLOSA

Contacts and locations

Locations

  • Cincinnati Children's Hospital Medical Center

    RECRUITING

    Cincinnati, Ohio, 45229, United States

  • Mission Dermatology Center

    RECRUITING

    Rancho Santa Margarita, California, 92688, United States

    Contact Email: •••••@•••••

  • Skin Research Institute

    RECRUITING

    Coral Gables, Florida, 33146, United States

    Contact Email: •••••@•••••

  • Texas Dermatology and Laser Specialists

    RECRUITING

    San Antonio, Texas, 78218, United States

  • UMass Memorial Medical Center

    RECRUITING

    Worcester, Massachusetts, 01605, United States

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