New hope for KRAS lung cancer: targeted pill plus immunotherapy in Late-Stage trial

NCT ID NCT07554339

Recruiting now Disease control Sponsor: Merck Sharp & Dohme LLC Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Aug 07, 2026 · Updated 10 times

Summary

This phase 3 trial tests whether adding the targeted pill calderasib (MK-1084) to the immunotherapy durvalumab helps people with a specific KRAS G12C-mutated lung cancer live longer without their cancer growing. About 310 participants who have finished chemotherapy and radiation without progression will receive either the drug combo or a placebo plus durvalumab. The study aims to see if the combination delays cancer progression and improves survival.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: calderasib (MK-1084) plus durvalumab
What this could lead to: If successful, this combination could offer a new treatment option to delay cancer growth or spread in people with a specific KRAS-mutated lung cancer.
What could go wrong: This is an early-phase 3 trial, so results are not guaranteed. The drug combination may cause side effects, and the benefit over standard care is uncertain.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

non-small cell lung carcinoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

NON-SMALL CELL LUNG CANCER

Contacts and locations

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Study contacts

Contact

Email: •••••@•••••

Locations

Ajou University Hospital ( Site 2504)
RECRUITING

Suwon, Kyonggi-do, 16499, South Korea
Asan Medical Center ( Site 2500)
RECRUITING

Seoul, 05505, South Korea
Athens Medical Center ( Site 1201)
RECRUITING

Athens, Attica, 151 25, Greece
Chungbuk National University Hospital ( Site 2502)
RECRUITING

Cheongju-si, North Chungcheong, 28644, South Korea
Clinica Adventista Belgrano ( Site 0304)
RECRUITING

Ciudad Autonoma de Buenos Aires, Buenos Aires, C1430EGF, Argentina
Communal Non-Commercial Enterprise "Prykarpatski Clinical Oncological Center" of Ivano-Frankivsk Reg ( Site 2006)
RECRUITING

Ivano-Frankivsk, Ivano-Frankivsk Oblast, 76018, Ukraine
Communal Noncommercial Enterprise "Podillia Regional Oncology Center Of Vinnytsia Regional Council" ( Site 2004)
RECRUITING

Vinnytsia, Vinnytsia Oblast, 21029, Ukraine
Fondazione Policlinico Universitario Agostino Gemelli IRCCS - Università Cattolica del Sacro Cuore ( Site 1401)
RECRUITING

Rome, Lazio, 00168, Italy
Fundación Instituto Valenciano de Oncología ( Site 1809)
RECRUITING

Valencia, Valenciana, Comunitat, 46009, Spain
Gemeinschaftspraxis für Hämatologie und Onkologie Münster ( Site 1108)
RECRUITING

Münster, North Rhine-Westphalia, 48153, Germany
Guangxi Medical University Affiliated Tumor Hospital ( Site 2202)
RECRUITING

Qingxiu District, Guangxi, 530022, China
HOSPITAL GENERAL UNIVERSITARIO GREGORIO MARAÑON ( Site 1803)
RECRUITING

Madrid, 28007, Spain
Hospital Britanico de Buenos Aires ( Site 0305)
RECRUITING

Buenos Aires, Buenos Aires F.D., C1280AEB, Argentina
Hospital Clinico San Carlos ( Site 1810)
RECRUITING

Madrid, 28040, Spain
Hospital Universitario La Paz ( Site 1808)
RECRUITING

Madrid, 28046, Spain
Hospital Universitario Virgen Macarena ( Site 1805)
RECRUITING

Seville, 41007, Spain
Hubei Cancer Hospital ( Site 2203)
RECRUITING

Wuhan, Hubei, 430070, China
Institut Català d'Oncologia (ICO) - Girona-Oncología Médica ( Site 1807)
RECRUITING

Girona, Gerona, 17007, Spain
Instituto de Investigaciones Clínicas Mar del Plata ( Site 0303)
RECRUITING

Mar del Plata, Buenos Aires, B7600FZO, Argentina
Keimyung University Dongsan Hospital ( Site 2503)
RECRUITING

Daegu, Taegu-Kwangyokshi, 42601, South Korea
Leids Universitair Medisch Centrum ( Site 1503)
RECRUITING

Leiden, South Holland, 2333 ZA, Netherlands
Lviv Oncology Regional Treatment and Diagnostic Center ( Site 2009)
RECRUITING

Lviv, Lviv Oblast, 79031, Ukraine
Lviv Territorial Medical Union Multidisciplinary Clinical Hospital ( Site 2000)
RECRUITING

Lviv, Lviv Oblast, 79059, Ukraine
ME RIVNE REGIONAL ANTITUMOR CENTER ( Site 2001)
RECRUITING

Rivne, Rivne Oblast, 33010, Ukraine
Mackay Memorial Hospital ( Site 2611)
RECRUITING

Taipei, 10449, Taiwan
Medical Center "Mriya Med-Service"-Clinical Research Department ( Site 2012)
RECRUITING

Kryvyi Rih, Dnipropetrovsk Oblast, 50000, Ukraine
Medical Center "Universal Clinic "Oberig" of Limited Liability Company "Kapytal" ( Site 2005)
RECRUITING

Kyiv, 03057, Ukraine
Metaxa Cancer Hospital of Piraeus ( Site 1203)
RECRUITING

Piraeus, Attica, 185 37, Greece
Municipal non-profit enterprise'Odesa Regional Clinical Hospital'of Odesa Regional Council ( Site 2011)
RECRUITING

Odesa, Odesa Oblast, 65025, Ukraine
NHO Revive Research Institute LLC ( Site 0118)
RECRUITING

Lincoln, Nebraska, 68506, United States
Nanjing Drum Tower Hospital ( Site 2224)
RECRUITING

Nanjing, Jiangsu, 210000, China
National Cancer Center ( Site 2505)
RECRUITING

Goyang-si, Kyonggi-do, 10408, South Korea
National Cheng Kung University Hospital ( Site 2601)
RECRUITING

Tainan, 704, Taiwan
New York Oncology Hematology P.C ( Site 9000)
RECRUITING

Albany, New York, 12206, United States
Private Enterprise Private Manufacturing Company Acinus-Medical and Diagnostic Centre ( Site 2013)
RECRUITING

Kropyvnytskyi, Kirovohrad Oblast, 25006, Ukraine
Radboudumc ( Site 1504)
RECRUITING

Nijmegen, Gelderland, 6525 GA, Netherlands
Regional Municipal Non-profit Enterprise "Bukovinian Clinical Oncology Center" ( Site 2002)
RECRUITING

Chernivtsi, Chernivetska Oblast, 58013, Ukraine
Sanatorio Parque ( Site 0302)
RECRUITING

Rosario, Santa Fe Province, S2000DSV, Argentina
Severance Hospital, Yonsei University Health System ( Site 2501)
RECRUITING

Seoul, 03722, South Korea
Shalimov Institute of Surgery and Transplantation ( Site 2003)
RECRUITING

Kyiv, Kyivska Oblast, 03680, Ukraine
Shandong Cancer Hospital ( Site 2200)
RECRUITING

Jinan, Shandong, 250117, China
Shanxi Provincial Cancer Hospital ( Site 2227)
RECRUITING

Taiyuan, Shanxi, 030013, China
Sichuan Cancer hospital. ( Site 2218)
RECRUITING

Chengdu, Sichuan, 610213, China
Taipei Medical University Shuang Ho Hospital ( Site 2612)
RECRUITING

New Taipei City, 23561, Taiwan
The First Affiliated Hospital of Xiamen University. ( Site 2239)
RECRUITING

Xiamen, Fujian, 361003, China
Tri-Service General Hospital ( Site 2608)
RECRUITING

Taipei, 114, Taiwan
Ukrainian Center of Tomotherapy ( Site 2014)
RECRUITING

Kropyvnytskyi, Kirovohrad Oblast, 25011, Ukraine
Union Hospital Tongji Medical College Huazhong University of Science and Technology-Medical Oncology ( Site 2206)
RECRUITING

Wuhan, Hubei, 430048, China
University General Hospital of Alexandroupoli ( Site 1206)
RECRUITING

Alexandroupoli, East Macedonia and Thrace, 681 00, Greece
University Medical Center Groningen ( Site 1505)
RECRUITING

Groningen, 9713 GZ, Netherlands
Volyn Regional Clinical Hospital ( Site 2010)
RECRUITING

Lutsk, Volyn Oblast, 43018, Ukraine
Zhongshan Hospital Affiliated to Xiamen University ( Site 2213)
RECRUITING

Xiamen, Fujian, 361000, China
Zhongshan Hospital affiliated to Fudan University ( Site 2215)
RECRUITING

Shanghai, Shanghai Municipality, 200030, China

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