New combo aims to stop KRAS-Mutant lung cancer from coming back

NCT ID NCT07431827

Recruiting now Disease control Sponsor: Merck Sharp & Dohme LLC Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Aug 14, 2026 · Updated 11 times

Summary

This Phase 3 trial is testing whether adding an experimental drug called calderasib (MK-1084) to standard immunotherapy (pembrolizumab) can keep non-small cell lung cancer from returning after surgery. The study enrolls 400 people with a specific KRAS G12C mutation whose cancer was completely removed. Participants receive either the drug combination or a placebo plus immunotherapy, and researchers will track how long they remain cancer-free.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Calderasib (MK-1084) oral tablet plus pembrolizumab and hyaluronidase injection
What this could lead to: If successful, this combination could help prevent lung cancer from returning after surgery in people with a specific KRAS mutation.
What could go wrong: This is an early-stage Phase 3 trial with no results yet. The added drug may cause side effects or not improve outcomes over standard treatment.

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Conditions

The condition(s) this trial relates to.

non-small cell lung carcinoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

NON-SMALL CELL LUNG CANCER

Contacts and locations

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Study contacts

Contact

Email: •••••@•••••

Locations

Adana Medical Park Seyhan Hastanesi ( Site 1827)
RECRUITING

Adana, 1140, Turkey (Türkiye)
Ankara Atatürk Sanatoryum Eğitim ve Araştırma Hastanesi ( Site 1825)
RECRUITING

Ankara, 06280, Turkey (Türkiye)
Ankara Bilkent Şehir Hastanesi ( Site 1811)
RECRUITING

Ankara, 06800, Turkey (Türkiye)
Asan Medical Center ( Site 3600)
RECRUITING

Seoul, 05505, South Korea
Athens Medical Center ( Site 1202)
RECRUITING

Athens, Attica, 151 25, Greece
Baskent University Dr. Turgut Noyan Research and Training Center ( Site 1812)
RECRUITING

Adana, 01250, Turkey (Türkiye)
Beijing Cancer hospital ( Site 2106)
RECRUITING

Beijing, Beijing Municipality, 100142, China
COMMUNAL NONPROFIT ENTERPRISE CLINICAL CENTER OF ONCOLOGY, HEMATOLOGY, TRANSPLANTOLOGY AND PALLIATI ( Site 1904)
RECRUITING

Cherkasy, Cherkasy Oblast, 18009, Ukraine
Centre Hospitalier de l'Université de Montréal ( Site 0219)
RECRUITING

Montreal, Quebec, H2X 3E4, Canada
Centre de Cancérologie du Grand Montpellier ( Site 1016)
RECRUITING

Montpellier, Languedoc-Roussillon, 34070, France
Centro de Educación Médica e Investigaciones clínicas "Dr. Norberto Quirno" (CEMIC) ( Site 0309)
RECRUITING

CABA, C1431FWO, Argentina
Chongqing University Three Gorges Hospital ( Site 2138)
RECRUITING

Chongqing, Chongqing Municipality, 404199, China
Communal Non-Commercial Enterprise Prykarpatski Clinical Oncological Center of Ivano-Frankivsk Regio ( Site 1900)
RECRUITING

Ivano-Frankivsk, Ivano-Frankivsk Oblast, 76018, Ukraine
Communal Noncommercial Enterprise "Podillia Regional Oncology Center Of Vinnytsia Regional Council" ( Site 1903)
RECRUITING

Vinnytsia, Vinnytsia Oblast, 21029, Ukraine
Communal noncommercial enterprise of Lviv regional council "Lviv oncological regional therapeutical ( Site 1908)
RECRUITING

Lviv, Lviv Oblast, 79031, Ukraine
Errikos Dunant Hospital Center ( Site 1201)
RECRUITING

Athens, Attica, 115 26, Greece
Evangelismos General Hospital of Athens ( Site 1204)
RECRUITING

Athens, Attica, 106 76, Greece
Faculdade de Medicina do ABC ( Site 0415)
RECRUITING

Santo André, São Paulo, 09060-870, Brazil
Fondazione IRCCS Istituto Nazionale dei Tumori ( Site 1400)
RECRUITING

Milan, Lombardy, 20133, Italy
Fourth Hospital Of Hebei Medical University ( Site 2107)
RECRUITING

Hshijiazhuang, Hebei, 050010, China
G. Papanikolaou General Hospital ( Site 1203)
RECRUITING

Thessaloniki, Central Macedonia, 570 10, Greece
Guangxi Medical University Cancer Hospital ( Site 2115)
RECRUITING

Nanning, Guangxi, 530200, China
H.R.U Malaga - Hospital General ( Site 1708)
RECRUITING

Málaga, 29010, Spain
HOSPITAL UNIVERSITARIO QUIRONSALUD MADRID ( Site 1707)
RECRUITING

Madrid, 28223, Spain
Hacettepe Universite Hastaneleri ( Site 1810)
RECRUITING

Ankara, 06410, Turkey (Türkiye)
Hospital Clinico San Carlos ( Site 1706)
RECRUITING

Madrid, 28040, Spain
Hospital Insular de Gran Canaria ( Site 1704)
RECRUITING

Las Palmas de Gran Canaria, Canary Islands, 35016, Spain
Hospital Italiano de Buenos Aires-Clinical Oncology ( Site 0306)
RECRUITING

CABA, C1199ABB, Argentina
Hospital Puerta de Hierro ( Site 1705)
RECRUITING

Majadahonda, Madrid, 28222, Spain
Hospital Universitari Vall d'Hebron ( Site 1700)
RECRUITING

Barcelona, 08035, Spain
Hospital Universitario Virgen Macarena ( Site 1709)
RECRUITING

Seville, 41009, Spain
Hospital Universitario la Paz ( Site 1710)
RECRUITING

Madrid, 28046, Spain
Institut Català d'Oncologia (ICO) - Girona ( Site 1703)
RECRUITING

Girona, Gerona, 17007, Spain
Instituto Alexander Fleming ( Site 0310)
RECRUITING

Ciudad Autónoma de Buenos Aires, Buenos Aires, C1426ANZ, Argentina
Kartal Lütfi Kırdar Şehir Hastanesi ( Site 1826)
RECRUITING

Istanbul, 34865, Turkey (Türkiye)
Keimyung University Dongsan Hospital ( Site 3605)
RECRUITING

Daegu, Taegu-Kwangyokshi, 42601, South Korea
Liv Hospital Ankara ( Site 1828)
RECRUITING

Ankara, 6680, Turkey (Türkiye)
Lviv Territorial Medical Union Multidisciplinary Clinical Hospital ( Site 1902)
RECRUITING

Lviv, Lviv Oblast, 79059, Ukraine
ME "Rivne Regional Antitumor Center" Rivne Regional Council ( Site 1912)
RECRUITING

Rivne, Rivne Oblast, 33010, Ukraine
Mackay Memorial Hospital ( Site 3701)
RECRUITING

Taipei, 10449, Taiwan
Medical Center "Mriya Med-Service" ( Site 1911)
RECRUITING

Kryvyi Rih, Dnipropetrovsk Oblast, 50000, Ukraine
Medical Center "Universal Clinic "Oberig" of Limited Liability Company "Kapytal" ( Site 1915)
RECRUITING

Kyiv, 03057, Ukraine
Mersin Sehir Eğitim ve Araştırma Hastanesi ( Site 1824)
RECRUITING

Mersin, 33240, Turkey (Türkiye)
Metaxa Cancer Hospital of Piraeus ( Site 1207)
RECRUITING

Piraeus, Attica, 185 37, Greece
Moncton Hospital ( Site 0200)
RECRUITING

Moncton, New Brunswick, E1C 6Z8, Canada
Municipal Enterprise "Volyn Regional Clinical Hospital" of Volyn Regional Council ( Site 1914)
RECRUITING

Lutsk, Volyn Oblast, 43018, Ukraine
Municipal non-profit enterprise'Odesa Regional Clinical Hospital'of Odesa Regional Council ( Site 1913)
RECRUITING

Odesa, Odesa Oblast, 65025, Ukraine
National Cancer Center ( Site 3603)
RECRUITING

Goyang-si, Kyonggi-do, 10408, South Korea
National Cheng Kung University Hospital ( Site 3706)
RECRUITING

Tainan, 704, Taiwan
Ningbo No. 2 Hospital ( Site 2124)
RECRUITING

Ningbo, Zhejiang, 315010, China
Northern Beaches Hospital ( Site 3009)
RECRUITING

Frenchs Forest, New South Wales, 2086, Australia
Peking Union Medical College Hospital ( Site 2105)
RECRUITING

Beijing, Beijing Municipality, 100730, China
Peking University People's Hospital ( Site 2100)
RECRUITING

Beijing, Beijing Municipality, 100044, China
Peninsula University Hospital ( Site 3011)
RECRUITING

Frankston, Victoria, 3199, Australia
Private Enterprise Private Manufacturing Company Acinus-Medical and Diagnostic Centre ( Site 1916)
RECRUITING

Kropyvnytskyi, Kirovohrad Oblast, 25006, Ukraine
Queen Mary Hospital ( Site 3100)
RECRUITING

Hong Kong, Hong Kong
Recep Tayyip Erdogan University Training and Research Hospital ( Site 1816)
RECRUITING

Rize, 53020, Turkey (Türkiye)
Regional Municipal Non-profit Enterprise "Bukovinian Clinical Oncology Center" ( Site 1909)
RECRUITING

Chernivtsi, Chernivetska Oblast, 58013, Ukraine
Sakarya Egitim ve Arastırma Hastanesi ( Site 1817)
RECRUITING

Sakarya, 54100, Turkey (Türkiye)
Sanatorio Parque ( Site 0311)
RECRUITING

Rosario, Santa Fe Province, S2000DSV, Argentina
Severance Hospital Yonsei University Health System ( Site 3601)
RECRUITING

Seoul, 03722, South Korea
Shalimov Institute of Surgery and Transplantation ( Site 1907)
RECRUITING

Kyiv, 03126, Ukraine
Shanghai Pulmonary Hospital ( Site 2125)
RECRUITING

Shanghai, Shanghai Municipality, 200000, China
Sichuan Cancer hospital ( Site 2101)
RECRUITING

Chengdu, Sichuan, 610000, China
Sir Run Run Shaw Hospital of Zhejiang University School of Medicine ( Site 2118)
RECRUITING

Hangzhou, Zhejiang, 310009, China
Sun Yat-sen University Cancer Center ( Site 2134)
RECRUITING

Guangzhou, Guangdong, 510060, China
THORACIC GENERAL HOSPITAL OF ATHENS "I SOTIRIA" ( Site 1206)
RECRUITING

Athens, Attica, 115 27, Greece
Taipei Medical University Shuang Ho Hospital ( Site 3700)
RECRUITING

New Taipei City, 235, Taiwan
The Affiliated Cancer Hospital of Xinjiang Medical ( Site 2110)
RECRUITING

Urumuqi, Xinjiang, 830054, China
The Catholic University of Korea St. Vincent s Hospital ( Site 3602)
RECRUITING

Suwon, Kyonggi-do, 16247, South Korea
The First Affiliated Hospital Of Fujian Medical University ( Site 2123)
RECRUITING

Fuzhou, Fujian, 350005, China
The First Affiliated Hospital of Nanchang University ( Site 2121)
RECRUITING

Nanchang, Jiangxi, 330000, China
The Third Peoples Hospital Of Chengdu ( Site 2141)
RECRUITING

Chengdu, Sichuan, 610031, China
The first Affiliated Hospital, Zhejiang University School of Medicine ( Site 2103)
RECRUITING

Hangzhou, Zhejiang, 310009, China
Tri-Service General Hospital ( Site 3708)
RECRUITING

Taipei, 11490, Taiwan
Tuen Mun Hospital ( Site 3102)
RECRUITING

Hong Kong, Hong Kong
Ukrainian Center of Tomotherapy ( Site 1917)
RECRUITING

Kropyvnytskyi, Kirovohrad Oblast, 25011, Ukraine
Union Hospital Tongji Medical College Huazhong University of Science and Technology ( Site 2139)
RECRUITING

Wuhan, Hubei, 430048, China
Xiangya Hospital Central South University ( Site 2136)
RECRUITING

Changsha, Hunan, 410008, China
Yunnan Province Cancer Hospital ( Site 2131)
RECRUITING

Kunming, Yunnan, 650118, China
Zhongshan Hospital of Fudan University ( Site 2119)
RECRUITING

Shanghai, Shanghai Municipality, 200032, China
İnönü Üniversitesi Turgut Özal Tıp Merkezi ( Site 1815)
RECRUITING

Malatya, 44280, Turkey (Türkiye)

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