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A gel injection may erase 'tech neck' lines, and a trial puts it to the test

NCT ID NCT05316233

Symptom relief Sponsor: AbbVie Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Sep 03, 2026 · Last updated Sep 04, 2026 · Updated 1 time

Summary

This Phase 3 trial tests whether JUVÉDERM VOLITE XC, a hyaluronic acid gel with lidocaine, can safely reduce horizontal neck lines and improve skin smoothness in adults. Participants with moderate to severe neck lines are randomly assigned to receive the gel or no treatment, with follow-up over several months. Researchers measure improvement using a standard scale and track side effects.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
JUVÉDERM VOLITE XC, a hyaluronic acid gel with lidocaine, injected into the neck
What this could lead to
If it works, this could offer a minimally invasive option for smoothing horizontal neck lines and improving skin texture.
What could go wrong
The trial is still testing safety and effectiveness, and results may not hold for everyone. Injections carry risks like swelling, bruising, or infection.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 3

Large-scale testing in a bigger group. Usually the last step before a treatment can be approved.

Participants

159 people

The number who actually took part.

Started

May 2022

Finished

Sep 2024

Lead sponsor

A company

The lead sponsor is a pharmaceutical, biotech, or medical-device company.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

22 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Participants in general good health as determined by Treating Investigator's judgment, including no known active pandemic infection. * Participants seeking improvement of transverse neck lines. * Has moderate or severe transverse neck lines (ATNLS Grade 2 or 3) based on EI live assessment. Exclusion Criteria: * Neck deformity or significant skin laxity with severe redundant folds. * Significant skin pigmentation disorders or discoloration in the neck area that would interfere with the visual assessment of the neck area. * Current cutaneous inflammatory or infectious processes (eg. acne, herpes), abscess, an unhealed wound, or a cancerous or precancerous lesion on the neck. * Tendency to develop hypertrophic scarring. * History of thyroid cancer, skin cancer of the neck, radiation of the treatment area, or de novo cancer in the treatment area. * Permanent soft tissue fillers in the neck area. * Semi-permanent soft tissue fillers in the neck area within 2 years before enrollment. * HA fillers or autologous fat in the neck area within 12 months before enrollment. * Mesotherapy, photomodulation, intense pulsed light, radiofrequency, dermabrasion, chemical peel, microneedling, laser, or other cosmetic procedures in the neck area within 12 months before enrollment. * Botulinum toxin in the neck area within 6 months before enrollment. * Deoxycholic acid injections or cryolipolysis in the submentum area within 6 months before enrollment. * Neck surgeries and procedures. * Neck tattoos, piercings, pigmentation, hair, or past trauma that would interfere with the visualization of the neck area for the effectiveness assessments. * Pregnant, nursing or planning a pregnancy.

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As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Neck lines

Contacts and locations

Locations

  • Aesthetic Solutions /ID# 239074

    Chapel Hill, North Carolina, 27517-9901, United States

  • Art of Skin MD /ID# 239071

    Solana Beach, California, 92075-2228, United States

  • Bellaire Dermatology Associates /ID# 239133

    Bellaire, Texas, 77401, United States

  • Center for Dermatology and Dermatologic Surgery /ID# 239137

    Washington D.C., District of Columbia, 20037-1445, United States

  • Cosmetic Laser Dermatology /ID# 239121

    San Diego, California, 92121-2119, United States

  • Delricht Research /ID# 242001

    New Orleans, Louisiana, 70115, United States

  • Hevia Cosmetic Dermatology /ID# 239118

    Coral Gables, Florida, 33134, United States

  • Laser & Skin surgery Medical group, Inc /ID# 241999

    Sacramento, California, 95816-5520, United States

  • Mariwalla Dermatology /ID# 239102

    West Islip, New York, 11795-4916, United States

  • Research Institute of the Southeast, LLC /ID# 239070

    West Palm Beach, Florida, 33401-2712, United States

  • Rkmd, Llc /Id# 239075

    North Bethesda, Maryland, 20852-3093, United States

  • Skin And Aesthetics Surgery Of Manhattan /ID# 243607

    New York, New York, 10022-3607, United States

  • Skin Research Institute LLC /ID# 239109

    Coral Gables, Florida, 33146-1837, United States

  • Steve Yoelin MD Medical Associate Inc /ID# 239072

    Newport Beach, California, 92663, United States

  • image Dermatology, P.C. /ID# 239136

    Montclair, New Jersey, 07042, United States

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