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New hope for hard-to-treat lymphoma: experimental drug enters human testing

NCT ID NCT06470438

Ongoing Disease control Sponsor: Janssen Research & Development, LLC Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jul 31, 2026 · Updated 3 times

Summary

This early-stage study tests a new oral drug, JNJ-88998377, in about 58 people with relapsed or refractory B-cell non-Hodgkin's lymphoma (a type of blood cancer). The main goals are to check the drug's safety and find the best dose for future studies. Participants must have measurable disease and be in relatively good health (ECOG 0 or 1).

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Conditions

The condition(s) this trial relates to.

B-cell non-Hodgkin lymphoma lymphoma, non-Hodgkin, familial non-Hodgkin lymphoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

LYMPHOMA, NON-HODGKIN REFRACTORY B-CELL NHL RELAPSED B-CELL NHL

Contacts and locations

Locations

  • A O U Sant Orsola Malpighi

    Bologna, 40138, Italy

  • Aidport Sp z o o

    Skorzewo, 60-185, Poland

  • Ankara Universitesi Hastaneleri Tibbi Farmakoloji Anabilim Dali Faz 1 Klinik Arastirma Merkezi

    Ankara, 06620, Turkey (Türkiye)

  • Beijing Cancer Hospital

    Beijing, 100142, China

  • Fudan University Shanghai Cancer Center

    Shanghai, 200032, China

  • Koc Universitesi Hastanesi Faz 1 Klinik Arastirma Merkezi

    Istanbul, 34010, Turkey (Türkiye)

  • Linkou Chang Gung Memorial Hospital

    Taoyuan, 33382, Taiwan

  • National Cancer Center Hospital

    Chūōku, 104 0045, Japan

  • National Cancer Center Hospital East

    Kashiwa, 277-8577, Japan

  • National Taiwan University Hospital

    Taipei, 10043, Taiwan

  • Pratia Onkologia Katowice

    Katowice, 40 519, Poland

  • SBU Ankara Dr. Abdurrahman Yurtaslan Onkoloji Egitim ve Arastirma Hastanesi Faz 1 Merkezi

    Ankara, 06200, Turkey (Türkiye)

  • Samsung Medical Center

    Seoul, 06351, South Korea

  • Seoul National University Hospital

    Seoul, 03080, South Korea

  • Sun Yat Sen University Cancer Center

    Guangzhou, 510062, China

  • Swietokrzyskie Centrum Onkologii SPZOZ w Kielcach, Klinika Hematologii i Transplantacji Szpiku

    Kielce, 25-734, Poland

  • The Cancer Institute Hospital of JFCR

    Tokyo, 135 8550, Japan

  • The First Affiliated Hospital Zhejiang University College of Medicine

    Hangzhou, 310002, China

  • Tianjin Medical University Cancer Institute and Hospital

    Tianjin, 300181, China

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