New hope for hard-to-treat myeloma: experimental drug enters phase 2 trial
NCT ID NCT07266441
First seen Jun 27, 2026 · Last updated Jul 31, 2026 · Updated 3 times
Summary
This study tests an experimental drug called JNJ-79635322 in people with multiple myeloma that has returned or stopped responding after at least 3 prior treatments. The goal is to see how well the drug shrinks or controls the cancer. About 157 participants will receive the drug and be monitored for response and side effects.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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AOU Policlinico Umberto I
RECRUITINGRoma, 00161, Italy
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ASST Papa Giovanni XXIII Bergamo
RECRUITINGBergamo, 24127, Italy
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Ankara University Medical Faculty
RECRUITINGAnkara, 06590, Turkey (Türkiye)
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Asan Medical Center
RECRUITINGSeoul, 05505, South Korea
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Azienda Ospedaliera S Croce e Carle Cuneo
RECRUITINGCuneo, 12100, Italy
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Azienda Ospedaliero Universitaria Careggi
RECRUITINGFlorence, 50134, Italy
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Azienda Ospedaliero Universitaria Policlinico Paolo Giaccone
RECRUITINGPalermo, 90127, Italy
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Banner MD Anderson Cancer Center
RECRUITINGGilbert, Arizona, 85234, United States
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Beijing Chaoyang Hospital
RECRUITINGChaoyang District, 100020, China
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Cancer Care Specialists of Central Illinois
RECRUITINGO'Fallon, Illinois, 62269, United States
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Cancer Specialists of North Florida
RECRUITINGJacksonville, Florida, 32256, United States
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Cancer and Blood Specialty Clinic
RECRUITINGLos Alamitos, California, 90720, United States
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Centro Ricerche Cliniche di Verona S r l
RECRUITINGVerona, 37134, Italy
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Chonnam National University Hwasun Hospital
RECRUITINGJeollanam-do, 58128, South Korea
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City of Hope
RECRUITINGDuarte, California, 91010, United States
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City of Hope Orange County Lennar Foundation Cancer Center
RECRUITINGIrvine, California, 92618, United States
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Cleveland Clinic Foundtation
RECRUITINGCleveland, Ohio, 44195, United States
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Colorado Blood Cancer Institute
RECRUITINGDenver, Colorado, 80218, United States
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Emory University
RECRUITINGAtlanta, Georgia, 30322, United States
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Ha'Emek Medical Center
RECRUITINGAfula, 1834111, Israel
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Hadassah Medical Center
RECRUITINGJerusalem, 9112000, Israel
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Hillel Yaffe Medical Center
RECRUITINGHadera, 3820302, Israel
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IRCCS Policlinico San Matteo, Università degli studi di Pavi
RECRUITINGPavia, 27100, Italy
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Istanbul Florance Nightingale Hospital
RECRUITINGIstanbul, 34381, Turkey (Türkiye)
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Levine Cancer Institute
RECRUITINGCharlotte, North Carolina, 28204, United States
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Liv Hospital Ankara
RECRUITINGAnkara, 06680, Turkey (Türkiye)
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MD Anderson Cancer Center
RECRUITINGHouston, Texas, 77030, United States
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Massachusetts General Hospital
RECRUITINGBoston, Massachusetts, 02114, United States
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Medipol University Hospital
RECRUITINGIstanbul, 34214, Turkey (Türkiye)
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Memorial Antalya Hospital
RECRUITINGAntalya, 07025, Turkey (Türkiye)
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Memorial Sloan Kettering Cancer Center
RECRUITINGNew York, New York, 10065, United States
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Mission Cancer Blood
RECRUITINGWaukee, Iowa, 50263, United States
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National Hospital Organization Okayama Medical Center
RECRUITINGOkayama, 701-1192, Japan
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National Hospital Organization Shibukawa Medical Center
RECRUITINGGunma, 377-0280, Japan
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NorthWest Medical Specialties, PLLC
RECRUITINGTacoma, Washington, 98405, United States
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Northside Hospital Cancer Institute
RECRUITINGAtlanta, Georgia, 30342, United States
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O Neal Comprehensive Cancer Center at UAB
RECRUITINGBirmingham, Alabama, 35294, United States
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Oncology Associates of Oregon PC Willamette Valley Cancer Institute
RECRUITINGEugene, Oregon, 97401, United States
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Oncology Consultants Texas
RECRUITINGHouston, Texas, 77030, United States
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Peking Union Medical College Hospital
RECRUITINGBeijing, 100006, China
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Policlinico Sant'Orsola Malpighi
RECRUITINGBologna, 40138, Italy
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Presidio Ospedaliero Pescara
RECRUITINGPescara, 65124, Italy
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Rabin Medical Center
RECRUITINGPetah Tikva, 4941492, Israel
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Rocky Mountain Cancer Centers
RECRUITINGAurora, Colorado, 80012, United States
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Rutgers Cancer Institute
RECRUITINGNew Brunswick, New Jersey, 08901, United States
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SCRI Oncology Partners
RECRUITINGNashville, Tennessee, 37203, United States
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Sakarya Üniversitesi Tıp Fakültesi Hastanesi
RECRUITINGSakarya, 54050, Turkey (Türkiye)
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Samodzielny Publiczny Zaklad Opieki Zdrowotnej Szpital Uniwersytecki w Krakowie
RECRUITINGKrakow, 30 688, Poland
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Samson Assuta Ashdod University Hospital
RECRUITINGAshdod, 7747629, Israel
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Samsung Medical Center
RECRUITINGSeoul, 06351, South Korea
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Seoul National University Hospital
RECRUITINGSeoul, 03080, South Korea
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Severance Hospital Yonsei University Health System
RECRUITINGSeoul, 03722, South Korea
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Shanghai Fourth People s Hospital
RECRUITINGShanghai, 200434, China
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Sun Yat Sen University Cancer Center
RECRUITINGGuangzhou, 510700, China
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Swietokrzyskie Centrum Onkologii SPZOZ w Kielcach
RECRUITINGKielce, 25 734, Poland
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Szpital Specjalistyczny w Brzozowie Podkarpacki Osrodek Onkologiczny im Ks B Markiewicza
RECRUITINGBrzozów, 36 200, Poland
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Tel Aviv Sourasky Medical Center
RECRUITINGTel Aviv, 6423906, Israel
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Tennessee Oncology, PLLC
RECRUITINGNashville, Tennessee, 37203, United States
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Texas Oncology
RECRUITINGAustin, Texas, 78705, United States
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Texas Oncology - Northeast
RECRUITINGTyler, Texas, 75702, United States
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The Catholic University of Korea Seoul St Marys Hospital
RECRUITINGSeoul, 06591, South Korea
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University of California San Francisco
RECRUITINGSan Francisco, California, 94143, United States
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University of Iowa
RECRUITINGIowa City, Iowa, 52242, United States
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University of Pennsylvania
RECRUITINGPhiladelphia, Pennsylvania, 19104, United States
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Uniwersytecki Szpital Kliniczny Nr 1 w Lublinie
RECRUITINGLublin, 20 081, Poland
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Uniwersytecki Szpital Kliniczny im Jana Mikulicza Radeckiego we Wroclawiu
RECRUITINGWroclaw, 50 367, Poland
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Uniwersytecki Szpital Kliniczny w Poznaniu
RECRUITINGPoznan, 60-569, Poland
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Virginia Cancer Specialists
RECRUITINGFairfax, Virginia, 22031, United States
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Virginia Oncology Associates
RECRUITINGNorfolk, Virginia, 23502, United States
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Wojewodzki Szpital Zespolony im L Rydygiera w Toruniu
RECRUITINGTorun, 87 100, Poland
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Wojewodzkie Wielospecjalistyczne Centrum Onkologii i Traumatologii im M Kopernika w Lodzi
RECRUITINGLodz, 93 513, Poland
More trials for these conditions
Other studies related to the condition(s) this trial covers.
- Could muscle loss predict blood cancer outcomes?
- Can a Triple-Action antibody deepen remissions in myeloma?
- Can a Low-Dose antifungal shield vulnerable patients from deadly fungal infections?
- Can a gentler chemo prep make stem cell transplants safer for blood cancer patients?
- Talking about the end: could guided conversations reduce futile cancer treatments?
- Can adding selinexor to standard therapy extend remission in Hard-to-Treat myeloma?