New hope for myeloma patients Who've run out of options?

NCT ID NCT02461888

Completed Disease control Sponsor: University of Leeds Source: ClinicalTrials.gov ↗

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This phase 2 trial tested a three-drug combination (ixazomib, cyclophosphamide, and dexamethasone) in 112 patients with multiple myeloma that had returned or stopped responding to three previous treatments. The goal was to see if adding ixazomib to standard chemotherapy could help control the disease longer. The study is now complete.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: ixazomib, cyclophosphamide, and dexamethasone
What this could lead to: If successful, this could offer a new treatment option for multiple myeloma patients who have stopped responding to other therapies.
What could go wrong: This is a phase 2 trial with only 112 participants, so results are preliminary. The combination may not work better than existing treatments and could have side effects.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

plasma cell myeloma Recurrence

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

MULTIPLE MYELOMA

Contacts and locations

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Locations

Barts and the London NHS Trust

London, E1 1BB, United Kingdom
Churchill Hospital

Oxford, OX3 7LE, United Kingdom
Guy's and St Thomas's NHS Foundation Trust

London, SE1 9RT, United Kingdom
Heart of England NHS Foundation Trust

Birmingham, B9 5ST, United Kingdom
Imperial College Healthcare NHS Trust

London, W2 1NY, United Kingdom
Leeds Teaching Hospitals NHS Trust

Leeds, LS9 7TF, United Kingdom
North Tees and Hartlepool NHS Foundation Trust

Hartlepool, TS24 9AH, United Kingdom
Nottingham University Hospital NHS Trust

Nottingham, NG7 2UH, United Kingdom
Queen Elizabeth Medical Centre

Birmingham, B15 2TH, United Kingdom
Royal Bournemouth General Hospital

Bournemouth, BH7 7DW, United Kingdom
Royal Liverpool and Broadgreen University Hospital NHS Trust

Liverpool, L7 8XP, United Kingdom
Royal Marsden Hospital

London, SW3 6JJ, United Kingdom
Sheffield Teaching Hospitals NHS Foundation Trust

Sheffield, S5 7AU, United Kingdom
Southampton University Hospital NHS Trust

Southampton, SO16 6YD, United Kingdom
The Christie NHS Foundation Trust

Manchester, M20 4BX, United Kingdom
The Royal Wolverhampton Hospital NHS Trust

Wolverhampton, WV10 0QP, United Kingdom
University College London Hospitals NHS Foundation Trust

London, NW1 2PG, United Kingdom
University Hospital Bristol NHS Foundation Trust

Bristol, BS1 3NU, United Kingdom

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