New lung cancer drug ivonescimab takes on pembrolizumab in major trial

NCT ID NCT06767514

Recruiting now Disease control Sponsor: Summit Therapeutics Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jul 22, 2026 · Updated 4 times

Summary

This phase 3 study compares ivonescimab, an experimental immunotherapy, to the standard drug pembrolizumab in 780 people with advanced non-small cell lung cancer that has high PD-L1 levels. Participants receive one of the two drugs as their first treatment. The study measures how long they live and how long their cancer stays under control.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: ivonescimab
What this could lead to: If ivonescimab works better than pembrolizumab, it could become a new first-line treatment option for people with advanced lung cancer whose tumors have high PD-L1 levels.
What could go wrong: This is a large phase 3 trial, but ivonescimab is still experimental. It may not prove superior to pembrolizumab, and side effects could be similar or worse. Results may not apply to all lung cancer patients.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

non-small cell lung carcinoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

NON-SMALL CELL LUNG CANCER

Contacts and locations

Locations

Clinical Site
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The Bronx, New York, 10461, United States
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Changzhou, Jiangsu, China
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Wenzhou, Zhejiang, China
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Chandler, Arizona, 85224, United States
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Phoenix, Arizona, 85006, United States
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Hot Springs, Arkansas, 71913, United States
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Alameda, California, 90720, United States
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Anaheim, California, 92805, United States
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Beverly Hills, California, 90211, United States
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Cerritos, California, 90703, United States
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Los Angeles, California, 90034, United States
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Los Angeles, California, 90067, United States
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Orange, California, 92868, United States
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Oxnard, California, 93030, United States
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San Diego, California, 92123, United States
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Sunnyvale, California, 94086, United States
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Torrance, California, 90505, United States
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Aurora, Colorado, 80045, United States
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Denver, Colorado, 80210, United States
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Grand Junction, Colorado, 81505, United States
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Lone Tree, Colorado, 80124, United States
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Loveland, Colorado, 80538, United States
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Fort Lauderdale, Florida, 33317, United States
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Jacksonville, Florida, 32207, United States
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Jacksonville Beach, Florida, 32256, United States
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North Venice, Florida, 34275, United States
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Orlando, Florida, 32822, United States
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Pensacola, Florida, 32504, United States
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Plantation, Florida, 33323, United States
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Tallahassee, Florida, 32308, United States
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Tamarac, Florida, 33321, United States
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West Palm Beach, Florida, 33401, United States
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Atlanta, Georgia, 30318, United States
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Warner Robins, Georgia, 31088, United States
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Carterville, Illinois, 62918, United States
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Chicago, Illinois, 60611, United States
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Chicago, Illinois, 60612, United States
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Evanston, Illinois, 60201, United States
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Indianapolis, Indiana, 46237, United States
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Waukee, Iowa, 50263, United States
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Lexington, Kentucky, 40503, United States
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Covington, Louisiana, 70433, United States
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Baltimore, Maryland, 21229, United States
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Boston, Massachusetts, 02215, United States
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Brighton, Massachusetts, 21350, United States
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Foxborough, Massachusetts, 02035, United States
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Methuen, Massachusetts, 01844, United States
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Milford, Massachusetts, 01757, United States
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Weymouth, Massachusetts, 02190, United States
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Worcester, Massachusetts, 01655, United States
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Ann Arbor, Michigan, 48109, United States
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Detroit, Michigan, 48201, United States
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Minneapolis, Minnesota, 55455, United States
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Saint Paul, Minnesota, 55101, United States
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Hattiesburg, Mississippi, 39401, United States
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Kansas City, Missouri, 64132, United States
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St Louis, Missouri, 63128, United States
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St Louis, Missouri, 63141, United States
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Lebanon, New Hampshire, 03756, United States
Clinical Study Site
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Mullica Hill, New Jersey, 08062, United States
Clinical Study Site
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New Brunswick, New Jersey, 08901, United States
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New York, New York, 10065, United States
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Syracuse, New York, 13210, United States
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Chapel Hill, North Carolina, 27514, United States
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Durham, North Carolina, 27708, United States
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Pinehurst, North Carolina, 28374, United States
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Cleveland, Ohio, 44195, United States
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Columbus, Ohio, 43219, United States
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Oklahoma City, Oklahoma, 73102, United States
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Eugene, Oregon, 97401, United States
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Portland, Oregon, 97239, United States
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Philadelphia, Pennsylvania, 19111, United States
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Pittsburgh, Pennsylvania, 15232, United States
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Nashville, Tennessee, 37235, United States
Clinical Study Site
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Abilene, Texas, 79601, United States
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Austin, Texas, 78745, United States
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Dallas, Texas, 75246, United States
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Fort Worth, Texas, 76104, United States
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Houston, Texas, 77030, United States
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Tyler, Texas, 75708, United States
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Webster, Texas, 77598, United States
Clinical Study Site
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Salt Lake City, Utah, 84106, United States
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Blacksburg, Virginia, 24061, United States
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Charlottesville, Virginia, 22908, United States
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Fairfax, Virginia, 22031, United States
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Richmond, Virginia, 23229, United States
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Richmond, Virginia, 23298, United States
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Seattle, Washington, 98109, United States
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Vancouver, Washington, 98684, United States
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Mons, Hainaut, 07000, Belgium
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Charleroi, 09600, Belgium
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Ghent, 09000, Belgium
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Edmonton, Alberta, T6G 1Z2, Canada
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Etobicoke, Ontario, M9V 1R8, Canada
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London, Ontario, N6A 5W9, Canada
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Montreal, Quebec, H3T 1E2, Canada
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Fuyang, Anhui, China
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Beijing, Beijing Municipality, China
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Fuzhou, Fujian, China
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Guangzhou, Guangdong, China
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Nanning, Guangxi, China
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Guiyang, Guizhou, China
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Haikou, Hainan, China
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Harbin, Heilongjiang, 150081, China
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Luoyang, Henan, China
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Nanyang, Henan, China
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Zhengzhou, Henan, China
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Changsha, Hunan, China
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Zhuzhou, Hunan, China
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Hohhot, Inner Mongolia, China
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Ganzhou, Jiangxi, China
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Nanchang, Jiangxi, China
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Changchun, Jilin, China
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Shenyang, Liaoning, China
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Jinan, Shandong, China
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Qingdao, Shandong, China
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Tai’an, Shandong, China
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Weifang, Shandong, China
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Xi’an, Shanxi, China
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Chengdu, Sichuan, China
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Luzhou, Sichuan, China
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Weihui, Xinxiang, China
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Kunming, Yunnan, China
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Hangzhou, Zhejiang, China
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Taizhou, Zhejiang, China
Clinical Study Site
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Beijing, China
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Shanghai, China
Clinical Study Site
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Nantes, Pays de Loire, 44277, France
Clinical Study Site
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Avignon, France
Clinical Study Site
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Brest, 29200, France
Clinical Study Site
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Créteil, 94010, France
Clinical Study Site
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Lille, 59000, France
Clinical Study Site
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Lyon, 69008, France
Clinical Study Site
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Marseille, 13000, France
Clinical Study Site
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Paris, 75020, France
Clinical Study Site
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Paris, 75248, France
Clinical Study Site
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Rennes, 35033, France
Clinical Study Site
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Strasbourg, France
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Toulon, France
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Toulouse, France
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Villejuif, 94800, France
Clinical Study Site
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Chemnitz, 09116, Germany
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Gauting, 82131, Germany
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Giesen, 35392, Germany
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Herne, 44651, Germany
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Karlsruhe, 76137, Germany
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Minden, 32429, Germany
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Möser, 47441, Germany
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Athens, 10431, Greece
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Athens, 15562, Greece
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Rio, 26504, Greece
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Thessaloniki, 54622, Greece
Clinical Study Site
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Budapest, 01121, Hungary
Clinical Study Site
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Budapest, 01122, Hungary
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Gyöngyös, 03200, Hungary
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Kecskemét, 06000, Hungary
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Rome, Italy, 00189, Italy
Clinical Study Site
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Bari, 70124, Italy
Clinical Study Site
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Bergamo, 24125, Italy
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Milan, 20037, Italy
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Milan, 20133, Italy
Clinical Study Site
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Milan, 20141, Italy
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Parma, 43126, Italy
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Rome, 00144, Italy
Clinical Study Site
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Nagoya, Aichi-ken, 460-0001, Japan
Clinical Study Site
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Kurume, Fukuoka, 830-0011, Japan
Clinical Study Site
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Asahikawa, Hokkaido, 078-8510, Japan
Clinical Study Site
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Nishinomiya, Hyōgo, 663-8501, Japan
Clinical Study Site
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Kanazawa, Ishikawa-ken, 920-8641, Japan
Clinical Study Site
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Tokyo, Japan, 104-0045, Japan
Clinical Study Site
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Kumamoto, Kumamoto, 861-4193, Japan
Clinical Study Site
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Matsusaka, Mie-ken, 515-8544, Japan
Clinical Study Site
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Sendai, Miyagi, 980-8574, Japan
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Omura-shi, Nagasaki, 856-8562, Japan
Clinical Study Site
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Okayama, Okayama-ken, 700-8558, Japan
Clinical Study Site
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Hirakata, Osaka, 573-1191, Japan
Clinical Study Site
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Osaka, Osaka, 541-8567, Japan
Clinical Study Site
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Hidaka, Saitama, 350-1298, Japan
Clinical Study Site
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Shimotsuke, Tochigi, 329-0498, Japan
Clinical Study Site
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Bunkyō-Ku, Tokyo, 113-8677, Japan
Clinical Study Site
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Koto-Ku, Tokyo, 135-8550, Japan
Clinical Study Site
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Wakayama, Wakayama, 641-8510, Japan
Clinical Study Site
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Sakai, 591-8555, Japan
Clinical Study Site
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Guadalajara, 44670, Mexico
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Guadalajara, 44680, Mexico
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Jalisco, 44680, Mexico
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Mexico City, 06700, Mexico
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Mexico City, 14080, Mexico
Clinical Study Site
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Monterrey, 64710, Mexico
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Veracruz, 91900, Mexico
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Gdansk, 80214, Poland
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Lodz, 93338, Poland
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Lublin, 20064, Poland
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Poznan, 60693, Poland
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Skorzewo, 60185, Poland
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Braga, Braga District, 4710-243, Portugal
Clinical Study Site
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Lisbon, Lisban, 1400-038, Portugal
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Porto, Portugal, 4200-072, Portugal
Clinical Study Site
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Coimbra, 3020-479, Portugal
Clinical Study Site
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Faro, 8000-386, Portugal
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Porto, 4099-001, Portugal
Clinical Study Site
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Cluj-Napoca, Cluj, 400015, Romania
Clinical Study Site
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Cluj-Napoca, Cluj, 400641, Romania
Clinical Study Site
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Cluj-Napoca, Cluj, 407280, Romania
Clinical Study Site
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Suceagu, Cluj, 407062, Romania
Clinical Study Site
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Ovidiu, Constanța County, 905900, Romania
Clinical Study Site
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Craiova, Dolj, 200542, Romania
Clinical Study Site
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Iași, Iaşi, 700106, Romania
Clinical Study Site
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Baia Mare, Maramureş, 430031, Romania
Clinical Study Site
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Timișoara, Timiș County, 300166, Romania
Clinical Study Site
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Timișoara, Timiș County, 300425, Romania
Clinical Study Site
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Bucharest, 022328, Romania
Clinical Study Site
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Belgrade, 11040, Serbia
Clinical Study Site
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Belgrade, 11080, Serbia
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Kragujevac, 34000, Serbia
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Novi Sad, 21204, Serbia
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Barakaldo, Bizkaia, 48903, Spain
Clinical Study Site
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Santander, Cantabria, 39008, Spain
Clinical Study Site
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Badajoz, Extremadura, 06080, Spain
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Las Palmas, Las Palmas, 35016, Spain
Clinical Study Site
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Madrid, Madrid, 28007, Spain
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Madrid, Madrid, 28040, Spain
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Sevilla, Madrid, 41014, Spain
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Marbella, Malaga, 29660, Spain
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Madrid, Martin Lagos, 28040, Spain
Clinical Study Site
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Seville, Seville, 41009, Spain
Clinical Study Site
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Barcelona, Spain, 08003, Spain
Clinical Study Site
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Barcelona, Spain, 08908, Spain
Clinical Study Site
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Madrid, Spain, 28034, Spain
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Madrid, Spain, 28041, Spain
Clinical Study Site
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Badalona, 08916, Spain
Clinical Study Site
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Burgos, 09006, Spain
Clinical Study Site
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Girona, 17007, Spain
Clinical Study Site
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Lugo, 27002, Spain
Clinical Study Site
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Málaga, 29011, Spain
Clinical Study Site
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Seville, 41014, Spain
Clinical Study Site
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Valencia, 46010, Spain
Clinical Study Site
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Valencia, 46026, Spain
Clinical Study Site
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Zaragoza, 50009, Spain
Clinical Study Site
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Istanbul, Bahcelievler, 34180, Turkey (Türkiye)
Clinical Study Site
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Ankara, Yenimahalle, 06200, Turkey (Türkiye)
Clinical Study Site
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Adana, 01230, Turkey (Türkiye)
Clinical Study Site
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Ankara, 06010, Turkey (Türkiye)
Clinical Study Site
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Ankara, 06230, Turkey (Türkiye)
Clinical Study Site
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Ankara, 06520, Turkey (Türkiye)
Clinical Study Site
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Ankara, 06590, Turkey (Türkiye)
Clinical Study Site
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Antalya, 07059, Turkey (Türkiye)
Clinical Study Site
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Diyarbakır, 21280, Turkey (Türkiye)
Clinical Study Site
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Gaziantep, 27060, Turkey (Türkiye)
Clinical Study Site
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Istanbul, 34098, Turkey (Türkiye)
Clinical Study Site
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Istanbul, 34460, Turkey (Türkiye)
Clinical Study Site
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Istanbul, 34722, Turkey (Türkiye)
Clinical Study Site
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Izmir, 35100, Turkey (Türkiye)
Clinical Study Site
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İzmit, 41380, Turkey (Türkiye)
Clinical Study Site
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Konya, 42080, Turkey (Türkiye)
Clinical Study Site
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Seyhan, 01140, Turkey (Türkiye)
Clinical Study Sites
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Jonesboro, Arkansas, 72401, United States
Clinical Study Sites
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Fort Lauderdale, Florida, 33308, United States
Clinical Study Sites
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Detroit, Michigan, 48202, United States
Clinical Study Sites
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Duluth, Minnesota, 55805, United States
Clinical Study Sites
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Cincinnati, Ohio, 45220, United States
Clinical Study Sites
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Columbus, Ohio, 43210, United States
Clinical Study Sites
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Nashville, Tennessee, 37203, United States
Clinical Study Sites
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Tianjin, China
Clinical Study Sites
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Esslingen am Neckar, 73701, Germany
Clinical Study Sites
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Athens, 12462, Greece
Clinical Study Sites
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Athens, 18547, Greece
Clinical Study Sites
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Orbassano, 10043, Italy
Clinical Study Sites
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Kyoto, Kyoto, 602-8566, Japan
Clinical Study Sites
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Mexico City, 10200, Mexico

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