New hope for elderly myeloma patients: drug combo trial launches

NCT ID NCT04751877

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This phase 3 trial is testing whether adding the drug isatuximab to a standard combination of lenalidomide and dexamethasone, with or without bortezomib, can improve outcomes for newly diagnosed multiple myeloma patients aged 65 to 79 who are not eligible for a stem cell transplant. The study will enroll 270 participants and measure how well the treatment reduces cancer cells to very low levels. The goal is to find a more effective and tolerable treatment option for this older population.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
Isatuximab, lenalidomide, bortezomib, and dexamethasone
What this could lead to
If successful, this could provide a more effective and tolerable treatment option for elderly multiple myeloma patients who cannot have a stem cell transplant.
What could go wrong
This is an early-phase study with a moderate number of participants. The combination may cause side effects, and it is not yet known if it will improve long-term outcomes compared to existing therapies.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Contacts and locations

Locations

  • CHU Poitiers

    Poitiers, 86000, France

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Other studies related to the condition(s) this trial covers.