New hope for rare kidney disease: iptacopan trial aims to protect kidneys

NCT ID NCT05755386

Recruiting now Disease control Sponsor: Novartis Pharmaceuticals Source: ClinicalTrials.gov ↗

First seen Jun 24, 2026 · Last updated Jul 14, 2026 · Updated 3 times

Summary

This study tests a drug called iptacopan in people with a rare kidney disease (IC-MPGN). About 106 adults and teens will receive either iptacopan or a placebo. The main goal is to see if iptacopan reduces protein in the urine and helps preserve kidney function over 18 months.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: iptacopan
What this could lead to: If successful, iptacopan could become a new treatment option to control IC-MPGN, reducing protein leakage and slowing kidney damage.
What could go wrong: This is a Phase 3 trial, but it's still experimental. The drug may not work better than placebo, and side effects are possible. Results may not apply to all patients.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

immunoglobulin-mediated membranoproliferative glomerulonephritis proteinuria

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

IC-MPGN

Contacts and locations

Locations

Baylor Scott and White Research
RECRUITING

Temple, Texas, 76502, United States
Boston Univ School of Medicine
RECRUITING

Boston, Massachusetts, 02118, United States
Childrens Hospital Colorado
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Aurora, Colorado, 80045, United States
Col Uni Med Center New York Presby
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New York, New York, 10032, United States
Emory University School of Medicine-Winship Cancer Institute
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Atlanta, Georgia, 30322, United States
MUSC Health Lancaster Med Ctr
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Lancaster, South Carolina, 29720, United States
Massachusetts General Hospital
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Boston, Massachusetts, 02114, United States
Nicklaus Childrens Hospital
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Miami, Florida, 33155, United States
Novartis Investigative Site
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CABA, Buenos Aires, C1425AGC, Argentina
Novartis Investigative Site
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CABA, Buenos Aires, C1425EFD, Argentina
Novartis Investigative Site
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Córdoba, Córdoba Province, X5000, Argentina
Novartis Investigative Site
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Buenos Aires, W3400ABH, Argentina
Novartis Investigative Site
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CABA, C1181ACH, Argentina
Novartis Investigative Site
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Santa Fe, S3000EPV, Argentina
Novartis Investigative Site
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Fortaleza, Ceará, 60430 370, Brazil
Novartis Investigative Site
WITHDRAWN

Brasília, Federal District, 71635-580, Brazil
Novartis Investigative Site
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Belo Horizonte, Minas Gerais, 30150-221, Brazil
Novartis Investigative Site
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Recife, Pernambuco, 50740-900, Brazil
Novartis Investigative Site
WITHDRAWN

Niterói, Rio de Janeiro, 24020 096, Brazil
Novartis Investigative Site
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Rio de Janeiro, Rio de Janeiro, 22211-230, Brazil
Novartis Investigative Site
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Natal, Rio Grande do Norte, 59012 300, Brazil
Novartis Investigative Site
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Porto Alegre, Rio Grande do Sul, 90035-074, Brazil
Novartis Investigative Site
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Botucatu, São Paulo, 18618-970, Brazil
Novartis Investigative Site
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Santo André, São Paulo, 09090-790, Brazil
Novartis Investigative Site
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Sao Jose Rio Preto, São Paulo, 15090-000, Brazil
Novartis Investigative Site
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São Paulo, São Paulo, 04038-002, Brazil
Novartis Investigative Site
WITHDRAWN

São Paulo, São Paulo, 05403 000, Brazil
Novartis Investigative Site
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São Paulo, São Paulo, 05403-000, Brazil
Novartis Investigative Site
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Salvador, 40323-010, Brazil
Novartis Investigative Site
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Etobicoke, Ontario, M9W 6V1, Canada
Novartis Investigative Site
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London, Ontario, N6A 5W9, Canada
Novartis Investigative Site
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Toronto, Ontario, M5G 2C4, Canada
Novartis Investigative Site
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Montreal, Quebec, H2X 1R9, Canada
Novartis Investigative Site
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Montreal, Quebec, H3T 1C5, Canada
Novartis Investigative Site
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Prague, 128 08, Czechia
Novartis Investigative Site
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Aarhus N, 8200, Denmark
Novartis Investigative Site
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Copenhagen, DK-2100, Denmark
Novartis Investigative Site
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Marseille, 13005, France
Novartis Investigative Site
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Montpellier, 34295, France
Novartis Investigative Site
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Paris, 75015, France
Novartis Investigative Site
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Rennes, 35033, France
Novartis Investigative Site
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Toulouse, 31054, France
Novartis Investigative Site
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Munich, Bavaria, 81377, Germany
Novartis Investigative Site
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Würzburg, Bavaria, 97080, Germany
Novartis Investigative Site
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Dresden, Saxony, 01307, Germany
Novartis Investigative Site
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Jena, Thuringia, 07740, Germany
Novartis Investigative Site
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Berlin, 13353, Germany
Novartis Investigative Site
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Essen, 45147, Germany
Novartis Investigative Site
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Hamburg, 20246, Germany
Novartis Investigative Site
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Hanover, 30625, Germany
Novartis Investigative Site
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Mainz, 55131, Germany
Novartis Investigative Site
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Ulm, 89081, Germany
Novartis Investigative Site
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Athens, 115 27, Greece
Novartis Investigative Site
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Chaïdári, 124 62, Greece
Novartis Investigative Site
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Heraklion Crete., 715 00, Greece
Novartis Investigative Site
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Ioannina, 455 00, Greece
Novartis Investigative Site
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Pátrai, 265 04, Greece
Novartis Investigative Site
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Thessaloniki, 54636, Greece
Novartis Investigative Site
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Thessaloniki, 570 10, Greece
Novartis Investigative Site
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Bangalore, Karnataka, 560004, India
Novartis Investigative Site
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Nagpur, Maharashtra, 440015, India
Novartis Investigative Site
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Pune, Maharashtra, 411011, India
Novartis Investigative Site
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New Delhi, National Capital Territory of Delhi, 110029, India
Novartis Investigative Site
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Hyderabad, Telangana, 500082, India
Novartis Investigative Site
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Haifa, 3109601, Israel
Novartis Investigative Site
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Jerusalem, 9103102, Israel
Novartis Investigative Site
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Petah Tikva, 4920235, Israel
Novartis Investigative Site
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Bari, BA, 70124, Italy
Novartis Investigative Site
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Ranica, BG, 24020, Italy
Novartis Investigative Site
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Brescia, BS, 25123, Italy
Novartis Investigative Site
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Milan, MI, 20122, Italy
Novartis Investigative Site
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Roma, RM, 00165, Italy
Novartis Investigative Site
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Torino, TO, 10126, Italy
Novartis Investigative Site
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Naples, 80131, Italy
Novartis Investigative Site
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Toyoake, Aichi-ken, 4701192, Japan
Novartis Investigative Site
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Fuchū, Tokyo, 1838561, Japan
Novartis Investigative Site
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Hachiōji, Tokyo, 193-0998, Japan
Novartis Investigative Site
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Okayama, 7008558, Japan
Novartis Investigative Site
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Osaka, 558-8558, Japan
Novartis Investigative Site
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Groningen, 9713 GZ, Netherlands
Novartis Investigative Site
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Poznan, Greater Poland Voivodeship, 60-355, Poland
Novartis Investigative Site
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Bialystok, 15-540, Poland
Novartis Investigative Site
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Krakow, 30-688, Poland
Novartis Investigative Site
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Olsztyn, 10-561, Poland
Novartis Investigative Site
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Warsaw, 02-006, Poland
Novartis Investigative Site
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Warsaw, 02-097, Poland
Novartis Investigative Site
WITHDRAWN

Wroclaw, 50-417, Poland
Novartis Investigative Site
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Martin, Slovakia, 036 59, Slovakia
Novartis Investigative Site
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Banská Bystrica, 975 17, Slovakia
Novartis Investigative Site
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Košice, 041 90, Slovakia
Novartis Investigative Site
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Seoul, Seoul, 03080, South Korea
Novartis Investigative Site
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Seoul, 03722, South Korea
Novartis Investigative Site
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Pamplona, Navarre, 31008, Spain
Novartis Investigative Site
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Almería, 04009, Spain
Novartis Investigative Site
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Barcelona, 08035, Spain
Novartis Investigative Site
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Barcelona, 08036, Spain
Novartis Investigative Site
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Madrid, 28040, Spain
Novartis Investigative Site
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Madrid, 28041, Spain
Novartis Investigative Site
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Madrid, 280796, Spain
Novartis Investigative Site
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Salamanca, 37007, Spain
Novartis Investigative Site
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Bern, 3010, Switzerland
Novartis Investigative Site
WITHDRAWN

Lausanne, 1011, Switzerland
Novartis Investigative Site
RECRUITING

Zurich, 8091, Switzerland
Novartis Investigative Site
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Kaohsiung City, 81346, Taiwan
Novartis Investigative Site
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Istanbul, Fatih, 34093, Turkey (Türkiye)
Novartis Investigative Site
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Izmir, Karsiyaka, 35575, Turkey (Türkiye)
Novartis Investigative Site
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Köseköy, Kocaeli, 41380, Turkey (Türkiye)
Novartis Investigative Site
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Kayseri, Melikgazi, 38039, Turkey (Türkiye)
Novartis Investigative Site
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Ankara, Yenimahalle, 06500, Turkey (Türkiye)
Novartis Investigative Site
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Mersin, Yenisehir, 33110, Turkey (Türkiye)
Novartis Investigative Site
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Belfast, BT9 7AB, United Kingdom
Novartis Investigative Site
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Cardiff, CF14 4XW, United Kingdom
Novartis Investigative Site
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London, NW3 2QG, United Kingdom
Novartis Investigative Site
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London, WC1N 3JH, United Kingdom
Novartis Investigative Site
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Manchester, M13 9WL, United Kingdom
Novartis Investigative Site
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Salford, M6 8HD, United Kingdom
Novartis Investigative Site
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Ho Chi Minh City, 700000, Vietnam
OHSU Dept of Nephrology
RECRUITING

Portland, Oregon, 97239, United States
Olive View UCLA Medical Center
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Sylmar, California, 91342, United States
Prolato Clinical Research Center
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Houston, Texas, 77054, United States
Ronald Reagan UCLA Medical Center
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Los Angeles, California, 90095, United States
UCSF
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San Francisco, California, 94115, United States
UT Southwestern Medical Center
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Dallas, Texas, 75235, United States
Univ Cali Irvine ALS Neuromuscular
RECRUITING

Orange, California, 92868, United States
Univ of Pennsylvania Medical Center
RECRUITING

Philadelphia, Pennsylvania, 19104, United States
University Of Cincinnati
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Cincinnati, Ohio, 45267, United States
University of Minnesota
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Minneapolis, Minnesota, 55455, United States
University of New Mexico
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Albuquerque, New Mexico, 87131-0001, United States
University of Utah
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Salt Lake City, Utah, 84113, United States
University of Wisconsin
RECRUITING

Madison, Wisconsin, 53792, United States
Washington University in St Louis
RECRUITING

St Louis, Missouri, 63110, United States

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