Could a direct brain artery injection improve stroke recovery?
NCT ID NCT06781385
First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 2 times
Summary
This phase 2 trial tests whether giving the clot-busting drug tenecteplase directly into the brain artery after standard clot removal is safe and feasible for people with severe stroke. About 40 participants who had a large artery blockage will receive either the drug or a saltwater placebo. The study focuses on bleeding risks and survival at 30 and 90 days.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Tenecteplase (a clot-busting drug)
What this could lead to
If it works, this could point toward a better way to clear remaining clots and improve recovery after a major stroke.
What could go wrong
This is a small, early-phase safety study (40 people). The drug may increase bleeding in the brain, and results may not apply to all stroke patients.
Disclaimer
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This is a summary of
the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
-
Atrium Health Neurosciences Institute
Charlotte, North Carolina, 28207, United States
More trials for these conditions
Other studies related to the condition(s) this trial covers.
- New aspiration tubing aims to restore blood flow faster in major strokes
- Wearable bracelet could alert stroke patients within 3 hours
- Smart bracelets could shave minutes off stroke treatment time
- Virtual reality could boost stroke recovery, early trial hints
- Clot-Removal procedure may offer hope for severe brain stem strokes
- New suction device aims to cut pneumonia risk in stroke patients