Could a direct brain artery injection improve stroke recovery?
NCT ID NCT06781385
First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 2 times
Summary
This phase 2 trial tests whether giving the clot-busting drug tenecteplase directly into the brain artery after standard clot removal is safe and feasible for people with severe stroke. About 40 participants who had a large artery blockage will receive either the drug or a saltwater placebo. The study focuses on bleeding risks and survival at 30 and 90 days.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- Tenecteplase (a clot-busting drug)
- What this could lead to
- If it works, this could point toward a better way to clear remaining clots and improve recovery after a major stroke.
- What could go wrong
- This is a small, early-phase safety study (40 people). The drug may increase bleeding in the brain, and results may not apply to all stroke patients.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
Atrium Health Neurosciences Institute
Charlotte, North Carolina, 28207, United States
More trials for these conditions
Other studies related to the condition(s) this trial covers.
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