Lung scans could show which asthma inhaler hits the right spot
NCT ID NCT02227394
First seen Sep 25, 2026 · Last updated Sep 25, 2026
Summary
Researchers are testing whether a new budesonide/formoterol inhaler (Z7200) behaves like the standard Symbicort Turbohaler in adults with asthma. The trial uses CT-based functional respiratory imaging and computer simulations to track how much drug reaches different parts of the lungs. Twenty participants take each inhaler in turn, and researchers measure airway volume, airway resistance, and where particles settle. They also check lung function, walking capacity, and breathing discomfort.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- a budesonide/formoterol combination inhaler
- What this could lead to
- If the imaging approach works, it could give doctors a clearer picture of where inhaled asthma drugs land in the lungs and help compare inhalers more precisely.
- What could go wrong
- This is a small Phase 2 study of 20 people, so it cannot prove one inhaler works better than another. Imaging measures may not translate into real differences in symptoms or long-term asthma control.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
-
Phase 2
Tests whether the treatment actually works, and watches for side effects, in a larger group.
- Participants
-
20 people
The number who actually took part.
- Start date
-
Aug 2014
- Finished
-
Nov 2014
- Lead sponsor
-
A company
The lead sponsor is a pharmaceutical, biotech, or medical-device company.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
-
18 years and older
- Sex
-
Anyone
- Healthy volunteers
-
Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: 1. Male or female patient ≥ 18 years old. 2. Written informed consent obtained. 3. Patient with a documented diagnosis of asthma according to the Global Initiative for Asthma (GINA) guidelines 4. Patient with a co-operative attitude and ability to correctly use the DPI. 5. Female patient of childbearing potential who confirm that a reliable method of contraception was used at least 14 days before visit 1 and will continue to use a reliable method of contraception during the study, or post-menopausal women (at least 12 months of amenorrhea) 6. Patient must be stable and treated in accordance with the GINA guidelines. 7. Patient must be a non-smoker or ex-smoker who have stopped smoking at least 1 month prior to visit 1 and has a smoking history of \< 10 pack years. 8. Patient must be able to understand and complete the protocol requirements, instructions, questionnaires and protocol-stated restrictions. Exclusion Criteria: 1. Pregnant or lactating female. 2. Unstable patient who developed an asthma exacerbation in the 4 weeks before screening. 3. Patient with upper or lower airways infection in the 4 weeks before screening. 4. Patient unable to perform pulmonary function testing. 5. Patients unable to withdraw fixed combination or long acting bronchodilator inhalation products 6. Patient with an uncontrolled disease or any condition that might, in the judgement of the investigator, place the patient at undue risk or potentially compromise the results or interpretation of the study. 7. Patient with active lung cancer or any other chronic disease with poor prognosis and /or affecting patient status. 8. Patient with allergy, sensitivity or intolerance to study drugs and/ or study drug formulation ingredients. 9. Patient unlikely to comply with the protocol or unable to understand the nature, scope and possible consequences of the study. 10. Patient who received systemic corticosteroids within the last 4 weeks prior to visit 11. Patient who received any investigational new drug within the last 4 weeks prior to visit 1 and is participating in any clinical trial. 12. Patient with a history of alcohol or substance abuse that in the opinion of the investigator may be of clinical significance 13. Patient with diagnosis of Chronic Obstructive Pulmonary Disease (COPD). 14. Patients who has a lactose intolerance or history of allergy to milk proteins. 15. Patients treated with medications or herbal medicines that are strong cytochrome P450 3A4 (CYP3A4) inhibitors (e.g., ritonavir, indinavir, nelfinavir, saquinavir, atazanavir, ketoconazole, itraconazole, voriconazole, fluconazole, cyclosporine, mibefradil, nefazodone, clarithromycin, telithromycin, troleandromycin, norfloxacin, ciprofloxacin) or inducers (e.g. phenobarbital, phenytoin, barbiturates, carbamazepine, oxcarbazepine, rifabutin, rifampin, St John's wort) within 2 weeks prior to Screening Visit and during the study.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
Antwerp University Hospital
Edegem, Antwerp, 2650, Belgium
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Other studies related to the condition(s) this trial covers.
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