Asthma's hidden switch: scientists hunt for calcium channels in Kids' immune cells

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: For Asthmatic children arm : * Girl not in childbearing potential or taking contraceptive treatment * Asthma diagnosis in at least 6 months as defined by clinical symptoms (expiratory dyspnea, wheezing, sibilance) and respiratory function (reversibility of VEMS at least 12% after salbutamol administration) * Allergologic tests positives to airborne allergens : positive prick test and/or specific IgE \> 0,35 kU/L for at least one allergen * Asthma severity between mild to moderate based on Global initiative for asthma classification during more than one month with inhaled corticotherapies +/- long term action beta -mimetic long compounds (salmeterol, formoterol) * Patient insured with a social security scheme For control children arm : * Girl not in childbearing potential or taking contraceptive treatment * No medical history of asthma * No medical history of allergy or symptoms of allergy on skin (atopic dermatitis), respiratory tract (rhino-conjunctivitis, asthma) or food allergy Exclusion Criteria: For both arms: * Chronic respiratory pathology : known occlusive or restrictive respiratory syndrome like interstitial lung disease, neuromuscular disease, mucoviscidoses, respiratory tract abnormalities with cough, dyspnea or digital hippocratism. * History of pulmonary or nose and throat infectious disease during last 4 months * Parasitic disease non treated during last 3 months * Dyspnea during the inclusion * Systemic corticotherapy during the last 3 months before inclusion * Immunosuppressive therapy during the last 3 months before inclusion * Diabeta * Disease causing immune disorder * Infection during inclusion * Participation to another study witch implies medical treatment during last 3 months before inclusion For asthmatic children arm : * Chronic pulmonary pathology (excluding asthma) * Asthma exacerbation during inclusion * VEMS \< 70% of normal range or VEMS \< 70% of normal range after inhalation of serum (despite salbutamol administration) * Patient unable to complete pulmonary function testing